Leveraging H₂O₂ Levels for Biomedical Applications

Abstract

Hydrogen peroxide (H 2 O 2 )-responsive materials have been employed as drug delivery or diagnosis systems to treat or detect diseases with abnormal oxidative stress. A number of H 2 O 2 -responsive systems have been developed and they have achieved great progress in controlled drug delivery for disease treatment. However, pathological sites with elevated H 2 O 2 level, such as cancer and inflammation, have their own characteristics, therefore the design of material structures and the subsequent formulations should be reasonably designed to acquire maximized therapeutic effects.In this progress report, we overview the development of H 2 O 2 -responsive functional groups for constructing H 2 O 2 -responsive formulations, as well as the guidance for designing suitable formulations to treat each specific pathological condition. The challenges and perspectives in this field are also discussed.Hydrogen peroxide (H 2 O 2 )-stimulated systems have recently been employed to treat pathologic sites with abnormal oxidative stress. Here, an overview over the designing principles and strategies of drug delivery systems composing of H 2 O 2 -responsive materials for cancer, inflammation and diabetes is provided. Additionally, the diagnosis of diseases using H 2 O 2 -responsive fluorescent compounds is discussed.

Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy

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“…While development of CCL micelles with higher ROS sensitivity would be a promising approach, it is chemically challenging to design new and ultra-ROS-responsive domain. An alternative approach to address this issue could be manually elevating the ROS levels in cancer cells [31,32], thus magnifying the response of nanovehicles to ROS.…”

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