Leveraging a translational research approach to drive diagnostic and treatment advances for autism

Parker, Karen J.

doi:10.1038/s41380-022-01532-8

Cited by 11 publications

(13 citation statements)

References 101 publications

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“…As in other species, AVP and V1aR is expressed in social brain regions of primates ( 201 – 204 ) and is likely to influence their social behavior. For example, AVP concentration in CSF, but not CSF OXT or blood AVP concentration, predicts social functioning in Rhesus monkeys and positively correlates with time spent in social grooming ( 21 , 205 ). In humans, manipulation of AVP and V1aR systems have been explored as therapies for ASD, schizophrenia, and drug-abuse ( 21 , 53 , 206 , 207 ).…”

Section: Avp Action In Humans and Other Primatesmentioning

confidence: 99%

“…For example, AVP concentration in CSF, but not CSF OXT or blood AVP concentration, predicts social functioning in Rhesus monkeys and positively correlates with time spent in social grooming ( 21 , 205 ). In humans, manipulation of AVP and V1aR systems have been explored as therapies for ASD, schizophrenia, and drug-abuse ( 21 , 53 , 206 , 207 ). Indeed, CSF AVP is linked to ASD symptom severity in children ( 208 ) and blood AVP concentration may be useful in predicting social development outcomes in newborns ( 21 ).…”

Section: Avp Action In Humans and Other Primatesmentioning

confidence: 99%

“…Additionally, AVP contributes to avoidance and anxiety-like behavior in response to stressful situations ( 18 , 19 ). In humans, AVP has been implicated in psychopathology, as variations in the vasopressin V1a receptor (V1aR) gene and AVP serum levels are associated with autism spectrum disorder (ASD) ( 20 , 21 ). As such, there has been increasing interest in AVP mechanisms that regulate social behavior, thus opening up translational opportunities ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Modulation of social behavior by distinct vasopressin sources

Rigney

Vries²,

Petrulis³

2023

Front. Endocrinol.

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The neuropeptide arginine-vasopressin (AVP) is well known for its peripheral effects on blood pressure and antidiuresis. However, AVP also modulates various social and anxiety-related behaviors by its actions in the brain, often sex-specifically, with effects typically being stronger in males than in females. AVP in the nervous system originates from several distinct sources which are, in turn, regulated by different inputs and regulatory factors. Based on both direct and indirect evidence, we can begin to define the specific role of AVP cell populations in social behavior, such as, social recognition, affiliation, pair bonding, parental behavior, mate competition, aggression, and social stress. Sex differences in function may be apparent in both sexually-dimorphic structures as well as ones without prominent structural differences within the hypothalamus. The understanding of how AVP systems are organized and function may ultimately lead to better therapeutic interventions for psychiatric disorders characterized by social deficits.

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Section: Avp Action In Humans and Other Primatesmentioning

confidence: 99%

Section: Avp Action In Humans and Other Primatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modulation of social behavior by distinct vasopressin sources

Rigney

Vries²,

Petrulis³

2023

Front. Endocrinol.

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“…Although the biological underpinnings of motivated social behavior in primates are not well understood, emerging evidence suggests a role for the arginine vasopressin (AVP) signaling pathway (Parker, 2022). For example, deletion variants in the promoter region of the AVP receptor 1A-encoding gene may underlie within and between species differences in social personality, bonding, and response to social cues in chimpanzees and bonobos (Pan paniscus) (Anestis et al, 2014;Hopkins et al, 2014;Staes et al, 2014Staes et al, , 2015Staes et al, , 2016.…”

Section: Nonsocialmentioning

confidence: 99%

“…Naturally occurring low sociality in rhesus monkeys bears some similarity to the behavioral features observed in humans with autism spectrum disorder (ASD) (Parker, 2022). ASD is a neurodevelopmental disorder characterized by persistent social communication and interaction impairments (American Psychiatric Association, 2013; Maenner et al, 2020), which have been hypothesized to be motivational in nature (Chevallier et al, 2012; Dawson & Bernier, 2007; Itskovich et al, 2021).…”

Section: Introductionmentioning

confidence: 98%

Rhesus monkey sociality is stable across time and linked to variation in the initiation but not receipt of prosocial behavior

Talbot

Madrid

Rosso³

et al. 2022

American J Primatol

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Rhesus monkeys and humans are highly social primates, yet both species exhibit pronounced variation in social functioning, spanning a spectrum of sociality.Naturally occurring low sociality in rhesus monkeys may be a promising construct by which to model social impairments relevant to human autism spectrum disorder (ASD), particularly if low sociality is found to be stable across time and associated with diminished social motivation. Thus, to better characterize variation in sociality and social communication profiles, we performed quantitative social behavior assessments on N = 95 male rhesus macaques (Macaca mulatta) housed in large, outdoor groups. In Study 1, we determined the social classification of our subjects by rank-ordering their total frequency of nonsocial behavior. Monkeys with the greatest frequency of nonsocial behavior were classified as low-social (n = 20) and monkeys with the lowest frequency of nonsocial behavior were classified as highsocial (n = 21). To assess group differences in social communication profiles, in Study 2, we quantified the rates of transient social communication signals, and whether these social signals were initiated by or directed towards the focal subject. Finally, in Study 3, we assessed the within-individual stability of sociality in a subset of monkeys (n = 11 low-social, n = 11 high-social) two years following our initial observations. Nonsocial behavior frequency significantly correlated across the two timepoints (Studies 1 and 3). Likewise, low-social versus high-social classification accurately predicted classification two years later. Low-social monkeys initiated less prosocial behavior than high-social monkeys, but groups did not differ in receipt of prosocial behavior, nor did they differ in threat behavior. These findings indicate that sociality is a stable, trait-like characteristic and that low sociality is linked to diminished initiation of prosocial behavior in rhesus macaques. This evidence also suggests that low sociality may be a useful construct for gaining mechanistic insight into the social motivational deficits often observed in people with ASD.

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Tales from the life and lab of a female social neuroscientist

Parker

2023

Comprehensive Psychoneuroendocrinology

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Leveraging a translational research approach to drive diagnostic and treatment advances for autism

Cited by 11 publications

References 101 publications

Modulation of social behavior by distinct vasopressin sources

Modulation of social behavior by distinct vasopressin sources

Rhesus monkey sociality is stable across time and linked to variation in the initiation but not receipt of prosocial behavior

Tales from the life and lab of a female social neuroscientist

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