Levels of vitamin D and cardiometabolic disorders: Systematic review and meta-analysis

Parker, J. Cecil; Hashmi, Omar; Dutton, David R.; Mavrodaris, Angelique; Stranges, Saverio; Kandala, Ngianga‐Bakwin; Clarke, Aileen; Franco, Oscar H.

doi:10.1016/j.maturitas.2009.12.013

Cited by 381 publications

(277 citation statements)

References 73 publications

Supporting

Mentioning

235

Contrasting

Unclassified

Order By: Relevance

“…While traditionally associated with T2DM, the importance of insulin resistance in the etiology of T1DM is being increasingly recognised, albeit that the underlying mechanisms may differ from those in T2DM [33,34]. Low vitamin D levels are associated with insulin resistance in T2DM and its co-morbidities [35]. With respect to a causal link between vitamin D repletion and improved glucose homeostasis, limited studies have reported substantial improvements in glycaemic control (HbA 1c levels) in T1DM patients who achieved higher circulating 25OHD levels via supplementation [36,37].…”

Section: Discussionmentioning

confidence: 99%

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Bennett

McPeake

McCance

et al. 2014

Pregnancy Hypertension: An International Journal of Women's Car

View full text Add to dashboard Cite

Objective: The first aim of this study was to assess 25-hydroxy vitamin D (25OHD) concentrations in women with type 1 diabetes (T1DM) during pregnancy, post-delivery and also foetal (cord blood) 25OHD concentrations and to examine relationships between these. The second aim of the study was to investigate potential interactions between maternal body mass index (BMI) and foetal vitamin D status. A further study aim was to examine potential relationships between maternal 25OHD and glycosylated haemoglobin (HbA 1c ) throughout pregnancy. Research Design and Methods:This was an observational study of 52 pregnant controls without diabetes and 65 pregnant women with T1DM in a university teaching hospital. Maternal serum 25OHD was measured serially throughout the pregnancy and post-delivery. Cord blood 25OHD was measured at delivery. 25OHD was measured by liquid chromatography tandem mass spectrometry (LC-MS/MS).Results: Vitamin D deficiency (25OHD ,25 nmol/L) was apparent in both the T1DM subjects and controls at all 3 pregnancy trimesters. Vitamin D levels in all cord blood were ,50 nmol/L. Maternal 25OHD correlated positively with cord 25OHD at all 3 trimesters in the T1DM group (p = 0.02; p,0.001; p,0.001). 25OHD levels within cord blood were significantly lower for women with diabetes classified as obese vs. normal weight at booking [normal weight BMI ,25 kg/m 2 vs. obese BMI .30 kg/m 2 (nmol/L6SD); 19.93611.15 vs. 13.7364.74, p = 0.026]. In the T1DM group, HbA 1c at booking was significantly negatively correlated with maternal 25OHD at all 3 trimesters (p = 0.004; p = 0.001; p = 0.05). Conclusion:In T1DM pregnancy, low vitamin D levels persist throughout gestation and post-delivery. Cord blood vitamin D levels correlate with those of the mother, and are significantly lower in obese women than in their normal weight counterparts. Maternal vitamin D levels exhibit a significant negative relationship with HbA 1c levels, supporting a potential role for this vitamin in maintaining glycaemic control.

show abstract

Section: Discussionmentioning

confidence: 99%

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Bennett

McPeake

McCance

et al. 2014

Pregnancy Hypertension: An International Journal of Women's Car

View full text Add to dashboard Cite

show abstract

“…Evidence is mounting, largely from observational studies, that vitamin D reduces the risk of CVD incidence and death ( Parker et al, 2010;Semba et al, 2010). The mechanisms seem to include reduced risk of diabetes mellitus (Parker et al, 2010), chronic kidney disease (LaClair et al, 2005), hypertension (Vaidya and Forman, 2010) and inflammation (Guillot et al, 2010).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…Papers outlining the evidence for vitamin D in reducing the burden of diseases with the highest mortality rates for which vitamin D reduces incidence and mortality rates include those for CVD (Parker et al, 2010), cancer , bacterial and viral respiratory infections (Cannell et al, 2006;Liu et al, 2007), chronic obstructive pulmonary disease (COPD; Black and Scragg, 2005), tuberculosis (TB; Liu et al, 2007), diabetes (Parker et al, 2010;Pittas et al, 2010), musculoskeletal diseases leading to falls (Cauley et al, 2008;Pfeifer et al, 2009) and dementia (Grant, 2009a).…”

Section: Introductionmentioning

confidence: 99%

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Grant

2011

Eur J Clin Nutr

View full text Add to dashboard Cite

Background/Objectives: The goal of this work is to estimate the reduction in mortality rates for six geopolitical regions of the world under the assumption that serum 25-hydroxyvitamin D (25(OH)D) levels increase from 54 to 110 nmol/l. Subjects/Methods: This study is based on interpretation of the journal literature relating to the effects of solar ultraviolet-B (UVB) and vitamin D in reducing the risk of disease and estimates of the serum 25(OH)D level-disease risk relations for cancer, cardiovascular disease (CVD) and respiratory infections. The vitamin D-sensitive diseases that account for more than half of global mortality rates are CVD, cancer, respiratory infections, respiratory diseases, tuberculosis and diabetes mellitus. Additional vitamin D-sensitive diseases and conditions that account for 2 to 3% of global mortality rates are Alzheimer's disease, falls, meningitis, Parkinson's disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis. Increasing serum 25(OH)D levels from 54 to 110 nmol/l would reduce the vitamin D-sensitive disease mortality rate by an estimated 20%. Results: The reduction in all-cause mortality rates range from 7.6% for African females to 17.3% for European females. Reductions for males average 0.6% lower than for females. The estimated increase in life expectancy is 2 years for all six regions. Conclusions: Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.

show abstract

“…It was hypothesized that the associated was mediated by vitamin D3 synthesis. This hypothesis is supported by a recent metaanalysis of prediagnostic serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of cardiovascular disease [2]. However, vitamin D production is due only to ultraviolet-B (UVB) irradiance, not total insolation.…”

mentioning

confidence: 97%

Prevalence of apolipoprotein E epsilon4 allele may explain the geographical variation of coronary heart disease mortality rates in Western Europe

Grant

2010

Eur J Epidemiol

View full text Add to dashboard Cite

A paper by Wong [1] reported an inverse correlation between incident solar radiation and coronary heart disease (CHD) mortality rates in Western Europe. It was hypothesized that the associated was mediated by vitamin D3 synthesis. This hypothesis is supported by a recent metaanalysis of prediagnostic serum 25-hydroxyvitamin D [25(OH)D] levels and incidence of cardiovascular disease [2]. However, vitamin D production is due only to ultraviolet-B (UVB) irradiance, not total insolation. Since Nordic countries experience about a six-month vitamin D winter [3], oral intake of vitamin D is higher in northern Europe than in southern Europe, resulting in higher serum 25(OH)D levels in the north, as shown in Figure 8 in [1].An alternate explanation for the correlation with incidence solar radiation is the variation of the prevalence of apolipoprotein E epsilon4 (ApoE4) allele, which is a significant risk factor for CHD [4]. At higher latitudes, fresh fruits and vegetables are less readily available than at lower latitudes (see Figure 1 in [1]); as a consequence, prevalence of the ApoE4 allele increases with latitude. Based on data in Gerdes et al. [5], the prevalence of ApoE4 rises from 8.3% in Greece to 22% in Finland with a slope of 0.53% per degree latitude [6]. ApoE4 causes the liver to produce more cholesterol and the pancreas more insulin in order to store more food as fat when food is more abundant [6]. Average solar insolation falls from 4.7 kWh/m 2 per day at 37°N to 2.0 kWh/m 2 per day at 64°N [5]. The graph of CHD mortality rate vs. insolation in Figure 4 of [1] has a very similar shape to the insolation vs. latitude graph in Figure 3 of [1].Ecological studies of CHD in Europe can be difficult to do properly. In an ecological study I identified milk and sweeteners as important risk factors [7], but realized later that milk is not a risk factor [8]

show abstract

Levels of vitamin D and cardiometabolic disorders: Systematic review and meta-analysis

Cited by 381 publications

References 73 publications

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

Maternal vitamin D status in Type 1 diabetic pregnancy: Impact on neonatal vitamin D status and association with maternal glycaemic control

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Prevalence of apolipoprotein E epsilon4 allele may explain the geographical variation of coronary heart disease mortality rates in Western Europe

Contact Info

Product

Resources

About