Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients

Miura, Cristina Sayuri Nishimura; Estevão, D.; Lopes, J. D.; Itano, Eiko Nakagawa

doi:10.1080/714031057

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…37,43,46,49,50 Specimens other than sera (e.g., urine, saliva) have also been employed for the detection and monitoring of circulating antigens. [51][52][53][54][55] The best antigen to be used in diagnosis has not been established, although the gp43 protein has been more widely employed in all body fluids, 42,44,45,52,55 despite rare negative exceptions attributable to the low avidity of certain immunoglobulin subclasses present in patients' sera. 56,57 More recently, the P. brasiliensis 28-kDa protein was shown to represent a reliable antigen in immunoblotting tests.…”

Section: Diagnosismentioning

confidence: 99%

Pulmonary Paracoccidioidomycosis

Restrepo

Benard

Castro

et al. 2008

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Paracoccidioidomycosis (formerly known as South American blastomycosis) is produced by the thermally dimorphic fungus Paracoccidioides brasiliensis. Most often this mycosis runs a chronic progressive course affecting preferentially the lungs followed by the skin, mucous membranes, adrenals, and reticuloendothelial organs. Acute-subacute presentations can be observed in children and immunosuppressed patients. Occasionally, self-limited infections have been documented. Two types of clinical presentations are described, the acute-subacute (juvenile) and the chronic (adult) forms of the disease. Paracoccidioidomycosis predominates in adult males (13:1); this gender difference is not observed in children or adolescents. The mycosis is limited geographically to various Latin American countries, with the greatest number of cases originating in Brazil, The fungus's natural habitat has not been precisely defined, although it is supposed to be a soil-inhabiting microorganism. No outbreaks have been reported. P. brasiliensis is capable of entering into prolonged periods of latency as is demonstrated by its diagnosis in patients who have moved outside the recognized endemic areas. This review updates clinicians and laboratory workers on the characteristics of a mycosis seldom reported outside of the Latin American countries.

show abstract

Section: Diagnosismentioning

confidence: 99%

Pulmonary Paracoccidioidomycosis

Restrepo

Benard

Castro

et al. 2008

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

Detection of immune-complexed 9-O-acetylated sialoglycoconjugates in the sera of patients with pediatric acute lymphoblastic leukemia

Bandyopadhyay

Mukherjee

Chatterjee

et al. 2005

Journal of Immunological Methods

View full text Add to dashboard Cite

Effect of Fusarium verticillioides extract on specific antibody production against Paracoccidioides brasiliensis

Itano

Sasaki

Ribeiro

et al. 2008

WMJ

View full text Add to dashboard Cite

The aim of this study was to evaluate the effect of partially purified Fusarium verticillioides fumonisins (FB) on the specific humoral response in mice infected with Paracoccidioides brasiliensis (Pb), the agent of paracoccidioidomycosis (PCM). Four groups of male Swiss mice were used (total 44 mice): infected (Pb), treated (FB), infected and treated (Pb/FB) and uninfected and untreated (PBS). Groups Pb and Pb/FB were inoculated i.v. with 1x105 Pb yeast cells (strain Pb18) and, after 28 days, groups FB and Pb/FB were inoculated (s.c.) with partially purified FB from F. verticillioides (5x2.25 mg FB/kg body weight). After 7 days, the plasma levels of total IgG and anti-gp43 IgG (specific antibody) were analysed by immunoenzyme assay (ELISA). The total IgG level was higher in groups Pb, FB and Pb/FB than in PBS (P<0.05) and the anti-gp43 IgG level was raised in groups Pb and Pb/FB, but a significant result was obtained only in Pb/FB, relative to the other groups (P<0.05). In conclusion, FB or other components of F. verticillioides extracts significantly increase the specific antibody response in male Swiss mice infected with Pb.

show abstract

Levels of specific antigen (gp43), specific antibodies, and antigen-antibody complexes in saliva and serum of paracoccidioidomycosis patients

Cited by 3 publications

References 0 publications

Pulmonary Paracoccidioidomycosis

Pulmonary Paracoccidioidomycosis

Detection of immune-complexed 9-O-acetylated sialoglycoconjugates in the sera of patients with pediatric acute lymphoblastic leukemia

Effect of Fusarium verticillioides extract on specific antibody production against Paracoccidioides brasiliensis

Contact Info

Product

Resources

About