Levels of serum granulocyte colony-stimulating factor in patients with infections

Abstract

To clarify the physiologic roles of granulocyte colony-stimulating factor (G-CSF) in infectious states in vivo, we examined the serum levels of G-CSF in patients with infection. Serum samples from 24 patients in the acute stage of infection (14 men and 10 women, age 65 to 101, without hematologic disorders), as well as samples from 32 age- matched normal elderly volunteers were investigated. Sixteen of the initial 24 patients were reexamined after the recovery phase. G-CSF levels were examined by quantitative enzyme immunoassay. The G-CSF level in normal elderly controls, 25.3 +/- 19.7 pg/mL, was not different from that reported in other findings. There was no statistically significant relationship between their G-CSF level and peripheral white blood cell count or neutrophilic granulocyte count. The G-CSF level in the acute stage of infection was 731.8 +/- 895.0 pg/mL, with a range of 30 to 3,199 pg/mL. There was no significant difference in G-CSF levels between patients with respiratory tract infection and those with urinary tract infection. In all 16 cases examined, the serum G-CSF level in the acute stage of infection was significantly higher than that after recovery phase, the latter being the same as the level in normal elderly controls. G-CSF must therefore play a significant role in human infectious states in vivo.

Serum G‐CSF levels are not increased in patients with antibody‐induced neutropenia unless they are suffering from infectious diseases

“…The immune neutropenias comprise primary and secondary autoimmune neutropenia, neonatal immune neutropenia, and druginduced immune neutropenia. Elevated serum G-CSF levels have been reported in patients with bacterial infections (Kawakami et al, 1990), severe congenital neutropenia (SCN) due to a maturation arrest (Mempel et al, 1991), as well as in patients with aplastic anaemia (Watari et al, 1989).…”

Serum granulocyte colony‐stimulating factor levels in patients with urinary bladder tumour and various urological malignancies

“…In the 15 healthy donors tested, the serum G-CSF levels were below the sensitivity of the assay (i.e. <3Opg/mL) as found in previous studies [16,21]. Serum G-CSF levels in 13 of 141 (9.2%) patients with UBT were > 30 pg/mL and ranged between 42 and 1760 pg/mL (mean 328 pg/mL).…”

Leucocyte alkaline phosphatase identifies terminally differentiated normal neutrophils and its lack in chronic myelogenous leukaemia is not dependent on p210 tyrosine kinase activity

“…Analogously, the premature release of granulocytic cells into the blood stream prevents their exposure into the bone marrow to appropriate levels of G-CSF able to regulate LAP mRNA and protein expression. Moreover the low serum levels of G-CSF detected in the majority of CML patients without infection could be unable to induce LAP mRNA and protein synthesis in circulating granulocytes (Watari et al, 1989;Kawakami et al, 1990).…”