Levels of serum and cerebrospinal fluid enolase in the patients with cerebral vascular disease and other neurological diseases.

The increase of neuron-specific enolase in cerebrospinal fluid and plasma as a marker of neuronal damage in patients with acute brain infarction

“…14,20,[22][23][24]37,38 Our results demonstrated that concentrations of NSE in CSF and plasma in the patients with BI during the first 7 days after the onset of brain ischemia significantly increased when compared to control. The highest increase of NSE concentration in CSF and plasma was observed in severe infarction; it was somewhat less at moderate, and the lowest at mild BI.…”

“…14,20-24 Those results concerned individual cases of brain infarction (BI), in a small number of patients without data about the type of acute brain ischemia, or NSE concentration determined only in CSF or in plasma. [20][21][22][23][24] Based on the foregoing facts, it has been supposed that there are considerable changes in NSE concentration in CSF and plasma in patients with BI in the acute phase, and this can be significant in the early diagnosis of BI. The aim of this study was to measure NSE concentration in CSF and plasma in patients with BI in the acute phase and analyze the possible connection between NSE concentration and size of infarction, as well as the degree of neurological and functional deficiency.…”

Serum neurone‐specific enolase as an indicator of stroke volume

“…High levels of NSE have also been found in specimens of CSF taken from patients with acute stroke [13][14][15][16][17][18][19][20]. In most cases these studies were based on single samples, taken over a time interval that was either fairly wide or uncertain, from patients in whom the type of stroke was not always clear.…”