Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women

Abstract

SE is characterized by protein expression changes associated with glucose uptake. In endometria from PCOS women with hyperinsulinemia, reduced levels of WAVE family proteins could compromise the cell surface GLUT4 exposure and the consequent glucose uptake in this tissue.

Endometria from Obese PCOS Women with Hyperinsulinemia Exhibit Altered Adiponectin Signaling

“…The number of total subjects was 27. The calculated number per group was 9 assuming α = 0.05 and β = 0.2, according to our pre vious studies [8,9]. The distribution of the data was analyzed by KolmogorovSmirnov test.…”

Decidual Endovascular Trophoblast Invasion in Women with Polycystic Ovary Syndrome: An Experimental Case-Control Study

“…In addition, in endometrial from hyperinsulinemic and hyperandrogenic patients with PCOS, a significant reduction of the Wiskott-Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins and of Rabs proteins, has been detected (25). These proteins are crucial for the activity of the transmembrane glucose transporter 4 (GLUT4) (25), and their reduction could compromise cell surface GLUT4 exposure and consequent glucose uptake in the endometrium, with subsequent alterations in the metabolism of the endometrial cells. In fact, the expression of GLUT4 is known to be reduced in the endometria of PCOS patients, and this reduction is strongly influenced by insulin levels (26).…”

Current perspectives of insulin resistance and polycystic ovary syndrome

“…The insulin signalling pathway is impaired in the endometrium from women with PCOS hyperinsulinaemia [26]. Chronic anovulation, obesity and hyperinsulinaemia are all associated with PCOS as well as with endometrial carcinoma [27].…”