Levels of prolactin, progesterone, estradiol, luteinizing hormone and follicle stimulating hormone in infertile women in Calabar, Nigeria

Isong, Idongesit Kokoabasi; Okhormhe, Zibril A.; Bassey, Iya Eze; Okpokam, Dorathy Chioma; Usoro, Chinyere Adanna Opara

doi:10.18203/2320-1770.ijrcog20160588

Cited by 3 publications

(2 citation statements)

References 11 publications

(11 reference statements)

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“…Moreover, the number of follicles was significantly higher in the estrogen/CC group than in the sildenafil/CC and control groups. Similar to our study results, findings by earlier studies have shown that luteal phase estradiol priming may improve the synchronization of the pool of follicles available for controlled ovarian stimulation, resulting in more favorable responses to controlled ovarian stimulation [ 35 , 36 ]. A few randomized controlled studies (RCT) [ 35 , 36 , 37 ] to date have found that estradiol treatment was associated with a significant increase in the oocyte number; therefore, more rigorous RCT studies are still needed to determine whether adjuvant treatment with estrogen is beneficial.…”

Section: Discussionsupporting

confidence: 92%

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

Altyar

Boshra

Warda

et al. 2023

JPM

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Background: Uterine blood flow determines endometrial thickness. This study examined how vaginal sildenafil citrate and estradiol valerate altered endometrial thickness, blood flow, and fertility in infertile women. Methods: This study observed 148 infertile women whose infertility was unexplained. Group 1 comprised 48 patients who received oral estradiol valerate (Cyclo-Progynova 2 mg/12 h white tablets) from day 6 till ovulation was initiated with clomiphene citrate. A number of 50 participants in group 2 received oral sildenafil (Respatio 20 mg/12 h film-coated tablets) for 5 days starting the day after their previous menstrual period and finishing on the day they ovulated with clomiphene citrate. Group 3 was the control group, with 50 patients receiving clomiphene citrate (Technovula 50 mg/12 h tablets) ovulation induction from the 2nd to 7th day of cycle. All patients had transvaginal ultrasounds to determine ovulation, follicle count, and fertility. Miscarriage, ectopic pregnancy, and multiple pregnancies were monitored for three months. Results: The three groups’ mean ETs differed statistically at p = 0.0004. A statistically significant difference was found between the three groups in terms of the number of follicles, with 69% of patients in group 1 having one and 31% having two or more, 76% of patients in group 2 having one and 24% having two or more, and 90% of patients in the control group having one and 10% having two or more (p = 0.038). The clinical pregnancy rates of the three groups were 58%, 46%, and 27%, respectively (p = 0.005). The distribution of all side effects was not statistically different between the three groups. Conclusion: It is possible to claim that adding oral estrogen to clomiphene citrate therapy as an adjuvant therapy can improve endometrial thickness and, as a result, increase the pregnancy rates in unexplained infertility compared to sildenafil, especially in cases where the infertility has lasted less than two years. Most people who take sildenafil end up with a mild headache.

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Section: Discussionsupporting

confidence: 92%

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

Altyar

Boshra

Warda

et al. 2023

JPM

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“…In addition, both groups showed significant correlation between prolactin and other hormones, including LH, FSH, prolactin, testosterone, estradiol and progesterone (Table 4). These findings are in line with the results of a study 1556 showed a positive correlation between estradiol and progesterone with hyperprolactinemia in infertile women (Isong et al, 2016). …”

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confidence: 92%

Correlation of Prolactin With Thyroid-Stimulating Hormone and Female Sex Hormones in Infertile Women.

Atrooz¹,

Alghonmeen²,

Abukhalil.³

2017

IJAR

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Hormonal and biochemical disturbances play an important role in development of infertility cases. Therefore, this study was conducted to evaluate the prolactin level and to explore the association between prolactin and thyroid stimulating hormone (TSH) and other hormones in the diagnosed infertile women in Ma'an governorate. The study was performed on 151 women (age group 20-40 years) who visited the Gynecology and Obstetrics Department at Ma'an governmental hospital. The study sample was divided into three groups: fertile group (n= 27), primary infertile group (n= 82) and secondary infertile group (n= 42). The results showed high incidence of prolactin abnormalities in both primary and secondary infertile women (90% and 92%, respectively). Furthermore, TSH abnormalities were found in 90% of primary infertile and % 93 of secondary infertile women. In addition, the results revealed the positively significant correlation between TSH and the fertility. Positive correlations were found between the levels of prolactin and TSH in primary and secondary infertility. Also, there were positive correlations between the levels of prolactin and other hormones, including luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and progesterone. In conclusion, the present study revealed a significant correlation between prolactin and TSH and other hormones in infertile women. Therefore, assessment of serum TSH and prolactin levels are mandatory in the work up of all infertile women, especially those presenting with menstrual irregularities.

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Comparison of serum reproductive hormones, antioxidants, PGE2 and PGF2-α between primary and secondary infertile women in Calabar

Isong¹,

AO²,

A³

et al. 2017

APJR

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Levels of prolactin, progesterone, estradiol, luteinizing hormone and follicle stimulating hormone in infertile women in Calabar, Nigeria

Cited by 3 publications

References 11 publications

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

Correlation of Prolactin With Thyroid-Stimulating Hormone and Female Sex Hormones in Infertile Women.

Comparison of serum reproductive hormones, antioxidants, PGE2 and PGF2-α between primary and secondary infertile women in Calabar

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