Levels of Peripheral Th17 Cells and Th17-Related Cytokines in Patients with Ankylosing Spondylitis: A Meta-analysis

Su, Q. Y.; Zheng, Jingwen; Yang, Jingyuan; Zhang, Tong-Yuan; Song, Shaoxian; Zhao, Ran; Di, Jing-Kai; Zhang, Sheng‐Xiao; Wang, Caihong; Gao, Huiying

doi:10.1007/s12325-022-02240-z

Cited by 4 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, a recent meta-analysis has shown that IL-17 levels are increased in AS from the PB when compared to the HD. Of note, these levels are significantly higher in patients with active disease compared to those with inactive AS [ 164 ]. In addition, a higher number of IL-17-secreting cells have been found in AS facet joints than in those of subjects with osteoarthritis [ 65 ].…”

Section: Therapeutic Targets In Axial-spamentioning

confidence: 99%

Uncovering the Underworld of Axial Spondyloarthritis

Vescovo

Venerito

Iannone

et al. 2023

IJMS

View full text Add to dashboard Cite

Axial spondyloarthritis (axial-SpA) is a multifactorial disease characterized by inflammation in sacroiliac joints and spine, bone reabsorption, and aberrant bone deposition, which may lead to ankylosis. Disease pathogenesis depends on genetic, immunological, mechanical, and bioenvironmental factors. HLA-B27 represents the most important genetic factor, although the disease may also develop in its absence. This MHC class I molecule has been deeply studied from a molecular point of view. Different theories, including the arthritogenic peptide, the unfolded protein response, and HLA-B27 homodimers formation, have been proposed to explain its role. From an immunological point of view, a complex interplay between the innate and adaptive immune system is involved in disease onset. Unlike other systemic autoimmune diseases, the innate immune system in axial-SpA has a crucial role marked by abnormal activity of innate immune cells, including γδ T cells, type 3 innate lymphoid cells, neutrophils, and mucosal-associated invariant T cells, at tissue-specific sites prone to the disease. On the other hand, a T cell adaptive response would seem involved in axial-SpA pathogenesis as emphasized by several studies focusing on TCR low clonal heterogeneity and clonal expansions as well as an interindividual sharing of CD4/8 T cell receptors. As a result of this immune dysregulation, several proinflammatory molecules are produced following the activation of tangled intracellular pathways involved in pathomechanisms of axial-SpA. This review aims to expand the current understanding of axial-SpA pathogenesis, pointing out novel molecular mechanisms leading to disease development and to further investigate potential therapeutic targets.

show abstract

Section: Therapeutic Targets In Axial-spamentioning

confidence: 99%

Uncovering the Underworld of Axial Spondyloarthritis

Vescovo

Venerito

Iannone

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…As is known, aberrantly regulated T helper (Th) 17 immunity is a critical component in inducing AS phenotype [78,79], with increased levels in the number of Th17 cells in the peripheral blood and synovium of AS patients [78,80].…”

Section: Cytokines Involved In Bone Damage and Tissue Repair 61 The C...mentioning

confidence: 99%

Osteoimmunology of Spondyloarthritis

Fassio,

Atzeni,

Rossini

et al. 2023

IJMS

View full text Add to dashboard Cite

The mechanisms underlying the development of bone damage in the context of spondyloarthritis (SpA) are not completely understood. To date, a considerable amount of evidence indicates that several developmental pathways are crucially involved in osteoimmunology. The present review explores the biological mechanisms underlying the relationship between inflammatory dysregulation, structural progression, and osteoporosis in this diverse family of conditions. We summarize the current knowledge of bone biology and balance and the foundations of bone regulation, including bone morphogenetic protein, the Wnt pathway, and Hedgehog signaling, as well as the role of cytokines in the development of bone damage in SpA. Other areas surveyed include the pathobiology of bone damage and systemic bone loss (osteoporosis) in SpA and the effects of pharmacological treatment on focal bone damage. Lastly, we present data relative to a survey of bone metabolic assessment in SpA from Italian bone specialist rheumatology centers. The results confirm that most of the attention to bone health is given to postmenopausal subjects and that the aspect of metabolic bone health may still be underrepresented. In our opinion, it may be the time for a call to action to increase the interest in and focus on the diagnosis and management of SpA.

show abstract

“…MR can lessen the possible bias induced by confounding and reverse causality when compared to other statistical methods [26,27]. An association between immune cells and AS has been found in earlier observational studies [27,28]. In this work, we conducted an extensive two-way two-sample MR analysis to elucidate the causal relationship between immune cell properties and AS.…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study

Fei,

Yu,

et al. 2024

Arthritis Res Ther

View full text Add to dashboard Cite

Background Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological factors are important in the development of AS. Previous research on the connection between immunological inflammation and AS, however, has shown inconclusive results. Methods To evaluate the causal association between immunological characteristics and AS, a bidirectional, two-sample Mendelian randomization (MR) approach was performed in this study. We investigated the causal connection between 731 immunological feature characteristic cells and AS risk using large, publically available genome-wide association studies. Results After FDR correction, two immunophenotypes were found to be significantly associated with AS risk: CD14 − CD16 + monocyte (OR, 0.669; 95% CI, 0.544 ~ 0.823; P = 1.46 × 10−4; PFDR = 0.043), CD33dim HLA DR + CD11b + (OR, 0.589; 95% CI = 0.446 ~ 0.780; P = 2.12 × 10−4; PFDR = 0.043). AS had statistically significant effects on six immune traits: CD8 on HLA DR + CD8 + T cell (OR, 1.029; 95% CI, 1.015 ~ 1.043; P = 4.46 × 10−5; PFDR = 0.014), IgD on IgD + CD24 + B cell (OR, 0.973; 95% CI, 0.960 ~ 0.987; P = 1.2 × 10−4; PFDR = 0.021), IgD on IgD + CD38 − unswitched memory B cell (OR, 0.962; 95% CI, 0.945 ~ 0.980; P = 3.02 × 10−5; PFDR = 0.014), CD8 + natural killer T %lymphocyte (OR, 0.973; 95% CI, 0.959 ~ 0.987; P = 1.92 × 10−4; PFDR = 0.021), CD8 + natural killer T %T cell (OR, 0.973; 95% CI, 0.959 ~ 0.987; P = 1.65 × 10−4; PFDR = 0.021). Conclusion Our findings extend genetic research into the intimate link between immune cells and AS, which can help guide future clinical and basic research.

show abstract

Levels of Peripheral Th17 Cells and Th17-Related Cytokines in Patients with Ankylosing Spondylitis: A Meta-analysis

Cited by 4 publications

References 37 publications

Uncovering the Underworld of Axial Spondyloarthritis

Uncovering the Underworld of Axial Spondyloarthritis

Osteoimmunology of Spondyloarthritis

The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study

Contact Info

Product

Resources

About