Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients

Sarchielli, Paola; Alberti, Andrea; Floridi, A.; Gallai, Virgilio

doi:10.1212/wnl.57.1.132

Cited by 114 publications

(94 citation statements)

References 8 publications

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“…The present study also confirmed our previous finding of significantly higher levels of NGF in the CSF of CDH patients [18]. A significant positive correlation emerged between the CSF levels of BDNF and NGF in CDH patients.…”

Section: Discussionsupporting

confidence: 92%

“…In a recent study we demonstrated a significant increase in the levels of NGF in the cerebrospinal fluid of patients with CDH, and this increase appeared to be associated with an increase in the levels of the sensory neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) [18]. On the basis of the evidence of the relationship between NGF and BDNF and also between BDNF and glutamate transmission in nociceptive processing in experimental models, we undertook the present study to investigate levels of BDNF in the cerebrospinal fluid (CSF) of patients with CDH (including patients with simple or combination analgesic abuse) and in the CSF of healthy age-matched controls.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Brain-derived neurotrophic factor in cerebrospinal fluid of patients with chronic daily headache: relationship with nerve growth factor and glutamate levels

Sarchielli¹,

Alberti²,

Gallai

et al. 2002

J Headache Pain

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Brain-derived neurotrophic factor in cerebrospinal fluid of patients with chronic daily headache: relationship with nerve growth factor and glutamate levels

Sarchielli¹,

Alberti²,

Gallai

et al. 2002

J Headache Pain

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“…Based on our findings, it can be hypothesized that the failure of the inhibitory role of AEA can contribute to maintaining central sensitization in chronic head pain, and represents a further mechanism which intervenes in increasing the release of the sensory neuropeptide CGRP and NO production, together with nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) release via glutamatergic transmission (Sarchielli et al, 2001(Sarchielli et al, , 2002.…”

Section: Endocannabinoids In CM P Sarchielli Et Almentioning

confidence: 89%

Endocannabinoids in Chronic Migraine: CSF Findings Suggest a System Failure

Sarchielli

Pini²,

Coppola³

et al. 2006

Neuropsychopharmacol

120

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Based on experimental evidence of the antinociceptive action of endocannabinoids and their role in the modulation of trigeminovascular system activation, we hypothesized that the endocannabinoid system may be dysfunctional in chronic migraine (CM). We examined whether the concentrations of N-arachidonoylethanolamide (anandamide, AEA), palmitoylethanolamide (PEA), and 2-arachidonoylglycerol (2-AG) in the CSF of patients with CM and with probable CM and probable analgesic-overuse headache (PCM + PAOH) are altered compared with control subjects. The above endocannabinoids were measured by high-performance liquid chromatography (HPLC), and quantified by isotope dilution gas-chromatography/mass-spectrometry. Calcitonin gene-related peptide (CGRP) levels were also determined by RIA method and the end products of nitric oxide (NO), the nitrites, by HPLC. CSF concentrations of AEA were significantly lower and those of PEA slightly but significantly higher both in patients with CM and PCM + PAOH than in nonmigraineur controls (po0.01 and po0.02, respectively). A negative correlation was found between AEA and CGRP levels in CM and PCM + PAOH patients (r ¼ 0.59, po0.01 and r ¼ À0.65, po0.007; respectively). A similar trend was observed between this endocannabinoid and nitrite levels. Reduced levels of AEA in the CSF of CM and PCM + PAOH patients may reflect an impairment of the endocannabinoid system in these patients, which may contribute to chronic head pain and seem to be related to increased CGRP and NO production. These findings support the potential role of the cannabinoid (CB)1 receptor as a possible therapeutic target in CM.

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“…It is possible that the small number of patients in this latter group precluded the finding of any significant difference. A relationship between increased NF levels and chronic migraine was previously shown 8,9 , suggesting that the upregulation of these molecules production may contribute to neuroplastic changes that may be implicated in migraine chronificaton. In patients with TTH the relationship between NF and TTH chronification remains unclear and future studies with larger number of CTTH patients are still required.…”

Section: Discussionmentioning

confidence: 87%

“…Renan B. Domingues et al Neurotrophic factors in tension-type headache and reduced levels of GDNF were found in patients with CDH 8,9,10,11 . A recent study showed that patients with frequent ETTH had not significant different BDNF levels as compared with controls 6 .…”

mentioning

confidence: 99%

Neurotrophic factors in tension-type headache

Domingues

Duarte

Rocha

et al. 2015

Arq. Neuro-Psiquiatr.

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Tension-type headache (TTH) is the most prevalent headache and is associated with a high socioeconomical impact 1 . It has been suggested that episodic TTH (ETTH) is mainly due to peripheral mechanisms such as muscle tenderness. Central mechanisms leading to reduced pain threshold and sensitization in the trigeminal nucleus, thalamus, or somatosensory cortex are probably related with chronic TTH (CTTH) 2 . However, the precise mechanisms determining ETTH and the conversion of ETTH to CTTH remain largely unknown.Neurotrophic factors (NF) are a unique group of polypeptides responsible for neuron survival, axon growth, dendrite prunning, and the expression of essential proteins for the neuronal functioning. NF are classified in different families according to functional and structural characteristics, such as the glial cell line-derived neurotrophic factor (GNDF) family and the neurotrophin super-family that includes the brainderived neurotrophic factor (BDNF), the nerve-growth factor (NGF), the neurotrophin-3 (NT-3), and the neurotrophin-4/5 (NT-4/5) 3 . NF may play a role in nociception by regulating peripheral sensitivity of nociceptors and by modulating the central processing of nociceptive information 4 . Considering that peripheral nociceptors and central processing of nociceptive information are both potentially involved in the pathophysiology of TTH, it is reasonable to hypothetize that NF may be involved in TTH pathogenesis.The association between NF and primary headaches has already been investigated. Reduced BDNF and NGF platelet levels have been described in patients with migraine and chronic daily headache (CDH) 5 . BDNF was shown to be increased during migraine and cluster headache attacks 6,7 . Increased cerebrospinal fluid (CSF) levels of NGF and BDNF, ABSTRACTNeurotrophic factors (NF) are involved in pain regulation and a few studies have suggested that they may play a pathophysiological role in primary headaches. The aim of this study was to investigate NF levels in patients with tension type headache (TTH). We carried out a cross sectional study including 48 TTH patients and 48 age and gender matched controls. Beck Depression and Anxiety Inventories, and Headache Impact Test were recorded. Serum levels of NF were determined by ELISA. There were not significant differences between NF levels between TTH patients and controls. Patients with chronic and episodic TTH had not significant differences in NF levels. The presence of headache at the time of evaluation did not significantly alter the levels of NF. Depression and anxiety scores as well as headache impact did not correlate with NF levels. Our study suggest that the serum levels of NF are not altered in TTH.Keywords: tension-type headache, neurotrophic factors, depression, anxiety. RESUMOOs fatores neurotróficos (FN) participam da regulação da dor e podem ter um papel na fisiopatologia das cefaleias peimárias. O objetivo do presente estudo foi avaliar os níveis séricos de FN em pacientes com cefaleia do tipo tensional (CTT). Foi realizado cort...

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Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients

Cited by 114 publications

References 8 publications

Brain-derived neurotrophic factor in cerebrospinal fluid of patients with chronic daily headache: relationship with nerve growth factor and glutamate levels

Brain-derived neurotrophic factor in cerebrospinal fluid of patients with chronic daily headache: relationship with nerve growth factor and glutamate levels

Endocannabinoids in Chronic Migraine: CSF Findings Suggest a System Failure

Neurotrophic factors in tension-type headache

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