Levels of Leukotriene B₄ and Platelet Activating Factor in Gingival Crevicular Fluid in Renal Transplant Patients Receiving Cyclosporine A

Abstract

The results of this study indicate that CsA therapy does not have a significant effect on GCF LTB4 and PAF levels and that gingival inflammation seems to be the main reason for their elevation. In CsA-treated patients, alterations in LTB4 and PAF levels might play a role in CsA GO through some asyet unknown mechanism. To our knowledge, this is the first report describing the levels of lipid mediators in GCF of CsA-treated patients. We assume that further studies will contribute to the understanding of the pathogenesis of CsA-induced gingival overgrowth.

Adjunctive Systemic Use of Beta-Glucan in the Nonsurgical Treatment of Chronic Periodontitis

“…This finding is in agreement with previous reports which found lower GCF TGF-β1 concentrations at inflamed sites when compared with healthy sites (Buduneli et al, 2001, Gürkan et al, 2005Kuru et al, 2004a). Expression of GCF constituents as concentration could result in higher levels at healthy sites where GCF volume is very low (Curtis et al, 1988, Emingil et al, 2000. Therefore, in healthy sites, high levels of TGF-β1 in GCF may be related to low GCF volume.…”

Levels of platelet activating factor in gingival crevice fluid following periodontal surgical therapy

“…PAF has been discovered to be a soluble mediator and is found in a variety of body fluids, so it is conceivable that some cells secrete this mediator after synthesis (7). In the periodontology literature, PAF has been analyzed in blood (8), GCF (11,12,15), and saliva (16,35–37). It is considered that GCF reflects cellular activities in the surrounding periodontal tissues and the constituents of GCF are involved in tissue formation and remodeling (18,21,38).…”

“…Platelet activating factor (PAF) is a potent phospholipid mediator and synthesized by thrombocytes, neutrophils, macrophages, eosinophils and epithelial cells (6–12). This mediator is linked to many inflammatory and immune responses, including platelet stimulation, neutrophil and monocyte activation, increased vascular permeability, smooth muscle contraction and bone resorption with osteoclasts (8,11–14).…”

“…Platelet activating factor (PAF) is a potent phospholipid mediator and synthesized by thrombocytes, neutrophils, macrophages, eosinophils and epithelial cells (6–12). This mediator is linked to many inflammatory and immune responses, including platelet stimulation, neutrophil and monocyte activation, increased vascular permeability, smooth muscle contraction and bone resorption with osteoclasts (8,11–14). Elevated levels of PAF in gingival tissue (6,12), gingival crevicular fluid (GCF) (12,15), blood (8) in periodontal disease, and higher concentrations of PAF in gingival tissue in peri‐implantitis (14), have been previously detected.…”

Evaluation of Transforming Growth Factor‐β1 Level in Crevicular Fluid of Cyclosporin A‐Treated Patients

“…Therefore, we agree with the opinions of other investigators that different mediators and cytokines could act in concert in the clinical presentation of gingival overgrowth. 20,[33][34][35] TGF-β1 is mitogenic for fibroblasts and stimulates synthesis of collagen, fibronectin, elastin, and tissue inhibitors of metalloproteinases while it decreases production of collagenase. 12 Formation of collagen types 529 Table 2.…”