Levels of intra- and extracellular heat shock protein 60 in Kawasaki disease patients treated with intravenous immunoglobulin

Ji, Xu; Kang, Mi Jeong; Choi, Jeong-Hwa; Jeon, Hak-Soo; Han, Heon-Seok; Kim, Ji-Yoon; Son, Byoung Kwan; Lee, Young-Min; Hahn, Youn-Soo

doi:10.1016/j.clim.2007.05.006

Cited by 12 publications

(2 citation statements)

References 40 publications

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“…Redness or crust formation at the BCG inoculation site in KD patients was hypothetically predicted to cross-reaction between mycobacterium HSP65 and human homolog HSP63 (11,18,19). Kai-Sheng Hsieh et al, in a review on records of 28 KD patients, stated that although erythema at a BCG inoculation site is a useful diagnostic sign in KD, it may not be a good predictor of KD-CAE (20).…”

Section: Introductionmentioning

confidence: 99%

Erythema at BCG Inoculation Site in Kawasaki Disease Patients

Rezai

Shahmohammadi

2014

Mater Sociomed

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Introduction:Kawasaki disease is an acute, self-limiting childhood systemic vasculitis with unknown etiology. Because there is no diagnostic test for Kawasaki disease, the diagnosis is based on clinical criteria. An important clinical sign that is not included in the classical clinical criteria for Kawasaki disease is a reaction at the Bacille Calmette-Guérin inoculation site that are present in about 30-50% of Kawasaki disease patients.The aim:of this review was to highlight the usefulness of the inflammation at the Bacille Calmette-Guérin inoculation site for early diagnosis of Kawasaki disease, we conducted a literature review on Medline in PubMed area, Google scholar, Magiran and Scientific Information Database using the search terms “Kawasaki disease, Erythema, BCG, inoculation site, children, cardiac complications, coronary artery lesion, aneurysm, incomplete Kawasaki in 2013.Results and discussion:A total of 15 articles had been found. Erythema at the Bacille Calmette-Guérin inoculation site was found in 49.87% of Kawasaki disease patients. Coronary artery abnormalities were found in 10.3% of cases. According to this review, BCGitis is more prevalent than cervical lymphadenopathy and rash and it can be a useful criterion in the diagnosis of incomplete Kawasaki disease in cases not fulfills the classic criteria of at least four of the five findings.

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Section: Introductionmentioning

confidence: 99%

Erythema at BCG Inoculation Site in Kawasaki Disease Patients

Rezai

Shahmohammadi

2014

Mater Sociomed

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“…47 The global distribution of cell-penetrating IVIg across organs may account for the positive effects of its administration in a variety of conditions such as mesenteric ischemia-reperfusion injury of the intestine, 47 brain Aβ deposit formation, 48 experimental autoimmune diseases, 49 experimental thrombotic microangiopathy, 50 sepsis, 51 pulmonary fibrosis 52 and Kawasaki disease. 53 In addition, the intracellular presence of IVIg in the lung, ileum and liver 6 days after administration suggests that cell penetration should be taken into consideration during assessment of IVIg clinical effect as treatment cycles of IVIg, in humans and mouse disease models, include daily, weekly and monthly administration. 49, 54 …”

Section: Discussionmentioning

confidence: 99%

Immunological evidence and regulatory potential for cell‐penetrating antibodies in intravenous immunoglobulin

et al. 2015

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Anti-DNA cell-penetrating autoantibodies have been extensively studied in autoimmune but not in normal sera. We investigated herein the presence and properties of cell-penetrating antibodies (CPAbs) in intravenous immunoglobulin (IVIg), a blood product of pooled normal human IgG. IVIg cell penetration was observed into various cell lines, as well as cells from several organs of mice injected intravenously with IVIg therapeutic dose. In all cell types examined in vitro and in vivo, intracellular IgG localized in the cytoplasm, in contrast to the nuclear accumulation of disease-related CPAbs. IVIg was found to rapidly enter cells via an energy-independent mode. The CPAb-fraction was isolated and found to be polyreactive to nuclear and cytoplasmic components; although it corresponded to ~2% of IVIg, it accounted for its inhibitory effect on splenocyte activation. Investigation of IVIg cell penetration capacity provides insight into its mechanisms of action and may account for some of its beneficial effects in numerous diseases.

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HSP60 and Anti-HSP60 Antibodies in Vasculitis: They are Two of a Kind

Alard¹,

Dueymes²,

Youinou

et al. 2008

Clinic Rev Allerg Immunol

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Clinical and pathological manifestations present as heterogeneous in vasculitides. Thus, inflammation can affect arteries, arterioles, capillaries, venules, and veins toward major body regions. One common feature of vascular diseases appears to be the presence of anti-HSP60 autoantibodies arising either consecutively to infection and molecular mimicry reaction with bacterial HSP60, or following recognition of endogenous HSP60 translocated or bound onto the surface of stressed endothelial cells. Because their levels are very low in some diseases but strikingly upregulated in others, and because their frequencies vary from one vasculitis to another, anti-HSP60 autoantibodies might play a role in the pathological mechanisms that likely differ among the vascular diseases. Identification of the variety of HSP60 epitope specificities along with each vasculitis would help to understand such discrepancies.

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Levels of intra- and extracellular heat shock protein 60 in Kawasaki disease patients treated with intravenous immunoglobulin

Cited by 12 publications

References 40 publications

Erythema at BCG Inoculation Site in Kawasaki Disease Patients

Erythema at BCG Inoculation Site in Kawasaki Disease Patients

Immunological evidence and regulatory potential for cell‐penetrating antibodies in intravenous immunoglobulin

HSP60 and Anti-HSP60 Antibodies in Vasculitis: They are Two of a Kind

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