Levels of HIV‐1 in subgingival biofilm of HIV‐infected patients

Pavan, Priscila; Pereira, Viviane Tiago; Souza, Rodrigo Carvalho de; Souza, Celso Oliveira; Torres, Sandra Regina; Colombo, Ana Paula Vieira; Costa, Luciana Jesus da; Sansone, Carmelo; Uzeda, Milton de; Gonçalves, Lúcio Souza

doi:10.1111/jcpe.12306

Cited by 6 publications

(8 citation statements)

References 51 publications

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“…It should also be stressed that in the current analysis, when smokers and non‐smokers were examined together, no tested parameter correlated with viral load. This finding may corroborate what was demonstrated by other studies, which have shown that viral load, detectable or not, was not associated with the presence or progression of periodontal disease 21 , 33 …”

Section: Discussionsupporting

confidence: 91%

“…Conversely, another study demonstrated that lower levels of CD4+ were not associated with more periodontal disease, including HIV+ with or without HAART 39 . As remarked above, the increase in the frequency of BOP was not correlated to higher levels of CD4+, which is in agreement with the findings from other studies 33,34,40,41 . It should also be stressed that in the current analysis, when smokers and non‐smokers were examined together, no tested parameter correlated with viral load.…”

Section: Discussionsupporting

confidence: 90%

“…39 As remarked above, the increase in the frequency of BOP was not correlated to higher levels of CD4+, which is in agreement with the findings from other studies. 33,34,40,41 It should also be stressed that in the current analysis, when smokers and non-smokers were examined together, no tested parameter correlated with viral load. This finding may corroborate what was demonstrated by other studies, which have shown that viral load, detectable or not, was not associated with the presence or progression of periodontal disease.…”

Section: Discussionmentioning

confidence: 71%

“…A significant improvement in the counts of CD4+ compared to CD4+ nadir was observed, which may be responsible for the absence of opportunistic oral lesions. In conformity with this finding, Pavan et al 33 attributed the use of HAART to a low frequency of oral lesions in HIV+ patients. Moreover, measurements of PD in HIV+ without HAART might be higher compared with HIV+ patients using HAART with CP 34 .…”

Section: Discussionmentioning

confidence: 74%

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Periodontal Conditions in Human Immunodeficiency Virus–Positive Patients Under Highly Active Antiretroviral Therapy From a Metropolitan Area of Rio De Janeiro

Barreto¹,

Santos²,

Gomes

et al. 2016

Journal of Periodontology

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The current investigation demonstrates that HIV+ individuals under HAART presents a high prevalence of mild to moderate periodontal disease. Viral load levels, CD4+ nadir, and CD4+ counts may present a weak to moderate correlation to the number of missing teeth, periodontal diagnosis, moderate PD, and moderate CAL, which may also reflect some effect of these systemic conditions on the periodontal status.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 74%

See 2 more Smart Citations

Periodontal Conditions in Human Immunodeficiency Virus–Positive Patients Under Highly Active Antiretroviral Therapy From a Metropolitan Area of Rio De Janeiro

Barreto¹,

Santos²,

Gomes

et al. 2016

Journal of Periodontology

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“…Bacteria and viruses are more often detected in oral biofilm samples of immunocompromised compared with systemically healthy individuals . However, studies have shown increased concentrations of viruses in the subgingival oral biofilm of systemically healthy patients with periodontal and peri‐implant diseases compared with their respective controls.…”

Section: Introductionmentioning

confidence: 99%

Contribution of herpesviruses in the progression of periodontal and peri‐implant diseases in systemically healthy individuals

Binshabaib

ALHarthi

Salehpoor

et al. 2018

Reviews in Medical Virology

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The aim of this review was to assess the contribution of herpesviruses in the subgingival oral biofilm in the progression of periodontal and peri-implant diseases in systemically healthy individuals. The literature review was customized to summarize the pertinent information for the following reasons: (1) A systematic review regarding the role of herpesviruses in the etiopathogenesis of periodontal disease has recently been published; and (2) a limited number of studies have assessed the association of herpesviruses with peri-implant diseases. To date, five observational studies have assessed the presence of herpesviruses in the subgingival oral biofilm of individuals with peri-implant diseases. In these studies, dental implants were in place for up to approximately 8 years. In two studies, human cytomegalovirus (HCMV) was more often isolated from the peri-implant sulci of sites with than without peri-implantitis. In one study, a low prevalence of HCMV compared with Epstein-Barr virus (EBV) was associated with the progression of peri-implantitis. In previous studies, the presence of EBV in the subgingival oral biofilm was associated with the onset of peri-implantitis and peri-implant mucositis, respectively. Major limitations of the studies assessed were the absence of blinding and lack of power analysis for sample size estimation. In conclusion, the presence of herpesviruses in the periodontal and peri-implant subgingival oral biofilm is an indicator of periodontal and peri-implant diseases in systemically healthy individuals; however, further studies with a statistically justified sample-size are needed to understand and refine this association.

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Potential gingival crevicular fluid and serum biomarkers by stage of HIV infection

et al. 2017

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Levels of HIV‐1 in subgingival biofilm of HIV‐infected patients

Abstract: HIV-1 can be detected and quantified in the subgingival biofilm of HIV-infected individuals, but these findings are not associated with PHVL and periodontal clinical parameters.

Cited by 6 publications

References 51 publications

Periodontal Conditions in Human Immunodeficiency Virus–Positive Patients Under Highly Active Antiretroviral Therapy From a Metropolitan Area of Rio De Janeiro

Periodontal Conditions in Human Immunodeficiency Virus–Positive Patients Under Highly Active Antiretroviral Therapy From a Metropolitan Area of Rio De Janeiro

Contribution of herpesviruses in the progression of periodontal and peri‐implant diseases in systemically healthy individuals

Potential gingival crevicular fluid and serum biomarkers by stage of HIV infection

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