Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis

Abstract

Our data support the hypothesis that early increased, not decreased, inflammatory response as measured by our markers is associated with improved survival rate. A high negative correlation was found between some of these markers and Sequential Organ Failure Assessment score.

The role of microvesicles in tissue repair

“…65,66 The recent availability of diagnostics capable of quantifying MVs of a specific cell origin could be useful for understanding the cells/organs where injury is occurring. This approach will overlap what has been done in oncology.…”

Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Prevents Microparticle-Induced Vascular Hyporeactivity through the Regulation of Proinflammatory Proteins

“…When activated or during apoptosis, these cells can release plasma membrane vesicles called microparticles (MPs) (Martínez et al, 2005). Several studies have shown that in inflammatory diseases, such as diabetes (Sabatier et al, 2002), acute coronary syndromes (Mallat et al, 2000;Bernal-Mizrachi et al, 2003), preeclampsia (Meziani et al, 2006), or sepsis (Soriano et al, 2005), the enhanced level of circulating MPs is correlated with vascular dysfunction, suggesting that MPs might play a role in these pathologies. These data are reinforced by the in vitro studies showing that MPs generated from leukocytes induce cytokine release by endothelial cells Altieri, 1998, 1999).…”

Application of Flow Cytometry in the Studies of Microparticles

“…Other authors reported increased level of PMP in septic patients [Nieuwland et al, 2000, Mostefai et al, 2008]. Suprisingly, early elevated level of PMP and endothelial MP may predict a more favorable outcome in severe sepsis [Soriano et al, 2005].…”