Aim: This study describes the demographic, socioeconomic, and tumor-specific characteristics of patients who refuse breast cancer surgery. Materials and Methods: This is a retrospective study of breast cancer patients from 2004-2015 captured by the National Cancer Data Base. Demographic, socioeconomic, and tumor-specific predictors were compared between patients who refused breast cancer surgery versus those who agreed to surgery, using bivariate and multivariate models. Results: A total of 2,445,870 patients met the inclusion criteria. On multivariate analysis, black and Asian patients had higher odds of refusing surgical treatment compared to whites (OR=2.16, CI=2. p<0.001), (OR=1.58, p<0.001), respectively. Moreover, patients with government insurance (OR=1.97, CI=1.86-2.09, p<0.001) and uninsured patients (OR=3.91, p<0.001) were found to have higher odds of surgical treatment refusal when compared to patients with private insurance. Conclusion: Specific demographic and disease-specific characteristics are related to refusing potentially life-saving breast cancer surgery.In 2019, 1,762,450 new breast cancer cases and 606,880 cancer deaths are projected to occur in the United States (1). Furthermore, breast cancer is the most common cancer in women and second most common cause of cancer death (1). Refusing surgery is a brave decision that has a deleterious effect on breast cancer mortality and is more commonly related to advanced disease, which has a poor prognosis (2). Previous studies focused on patients with pancreatic cancer who refused surgery demonstrated that there were disparities in the refusal of cancer-directed surgery and that several variables, such as insurance, sex, and race, were independently associated to this outcome (3, 4). However, studies on breast cancer have not elucidated groups likely to refuse surgical treatment. Therefore, this study's objective was to describe the demographic, socioeconomic, and tumor-specific characteristics related to surgery refusal in the United States (US) breast cancer population using the National Cancer Database (NCDB).