Levels of CMV-reactive antibodies correlate with the induction of CD28null T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD)

Tan, Dino B.A.; Amran, Fathiah S; Teo, Teck‐Hui; Price, Patricia; Moodley, Yuben

doi:10.1038/cmi.2015.04

Cited by 12 publications

(19 citation statements)

References 12 publications

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“…This includes increased expression of PD-1 paralleling the decreased expression of CD28 and production of IFNγ [19]. In our patient cohort, we correlated increased CD28 null T-cells in COPD and AECOPD with CMV-IgG titres [20]. Our results build on the work by Lazar et al (2015) showing increased expression of CD39 on cells from bronchoalveolar lavage fluid and sputum of ex-smoking COPD patients than smokers and nonsmoking controls [15].…”

Section: Immunoregulatory Role Of Cd39 In Copdsupporting

confidence: 66%

An evaluation of CD39 as a novel immunoregulatory mechanism invoked by COPD

et al. 2016

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Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by increased pulmonary and systemic inflammation and commonly caused by bacterial and/or viral infection. Little is known about the T-cell dysregulation in AECOPD that promotes these outcomes.CD39 is an ectonucleotidase able to hydrolyse adenosine triphosphate to create adenosine that may inhibit T-cell responses in patients with AECOPD. Here T-cell expression of CD39 measured by flow cytometry was higher in AECOPD patients than stable COPD patients or healthy controls. Higher expression of CD39 was associated with higher levels of plasma soluble tumor necrosis factor receptor but lower interferon-γ (IFNγ) levels in supernatants from staphylococcal enterotoxin-B stimulated peripheral blood mononuclear cells. This links increased expression of CD39 with systemic inflammation and impaired T-cell responses (e.g. IFNγ). The blockade of CD39 pathways may be a novel approach to the control of AECOPD, reducing the dependency on antibiotics.

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Section: Immunoregulatory Role Of Cd39 In Copdsupporting

confidence: 66%

An evaluation of CD39 as a novel immunoregulatory mechanism invoked by COPD

et al. 2016

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“…However in HIV patients, Gianella et al [16] proposed that a higher CMV antibody level marks a better immune response as it reflects of lower CMV replication, hence a more controlled infection. Alternatively, higher CMV antibody titres may suggest repeated reactivations of CMV antigens in individuals with subtle immune deficiencies and chronic immune activation, explaining the high titres seen in patients with HIV disease [17] or chronic obstructive pulmonary disease (COPD) [18] and in the present study. It is also possible that NTM disease, HIV disease and COPD potentiate reactivations of CMV.…”

Section: Discussionmentioning

confidence: 88%

Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?

et al. 2016

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Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.

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“…Our study does not allow for conclusions on the potential mechanisms related to the association between CMV latency/reactivation and asthma traits. However, increasing with age prevalence of CMV DNA in the blood of asthma patients suggests that as for other chronic diseases, age‐associated immune dysregulation and systemic inflammation, associated with CMV infection, may contribute to asthma pathogenesis . Alternatively, the higher prevalence of CMV DNA in the blood of asthmatic subjects may result from virus reactivation as a consequence of typical for asthma‐impaired antiviral immunity, underlying asthmatic inflammation, and/or treatment with potentially immunosuppressive corticosteroids .…”

Section: Discussionmentioning

confidence: 99%

“…More recently, it has been suggested that CMV may play a role in the pathogenesis of chronic obstructive pulmonary disease . However, serum anti‐CMV IgG antibodies reflect only previous exposure to the virus and are not sensitive and useful for monitoring CMV infection . Therefore, the aim of our study was to assess the presence of CMV DNA in the blood of adult and elderly patients with bronchial asthma to establish potential association of CMV DNAemia with risk of asthma and asthma traits.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits

Kowalski

Wardzyńska

Studzińska

et al. 2017

Allergy

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Cytomegalovirus (CMV) IgG antibodies have been associated with inflammaging and immunosenescence. We aimed to assess the presence of CMV DNA in the blood of adult and elderly patients with bronchial asthma to establish potential association of CMV DNAemia with asthma and asthma characteristics. Eighty-five elderly asthmatics, 74 younger asthma patients, and 114 age-matched controls were recruited. The CMV DNA was detected using commercial artus assay in 10.7% of asthma patients, but was negative in all control individuals. The secondary assay identified CMV DNA in 41.5% of asthmatics and 13.3% of control subjects (P < .001). Presence of CMV DNA was associated with an increased risk of asthma and CMV DNA copy numbers correlated with some asthma traits, including respiratory parameters and exhaled breath nitric oxide. We conclude that CMV infection is associated with asthma and may contribute to the pathogenesis of asthmatic inflammation.

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Levels of CMV-reactive antibodies correlate with the induction of CD28null T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD)

Cited by 12 publications

References 12 publications

An evaluation of CD39 as a novel immunoregulatory mechanism invoked by COPD

An evaluation of CD39 as a novel immunoregulatory mechanism invoked by COPD

Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?

Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits

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