Levels of Circulating Cell-Free Nuclear and Mitochondrial DNA in Benign and Malignant Ovarian Tumors

Abstract

Elevated levels of circulating cell-free nuclear DNA and circulating cell-free mitochondrial DNA in epithelial ovarian cancer may have diagnostic value. Our finding suggests that the circulating molecules might be potential biomarkers in the disease.

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

“…While the levels of circulating mtDNA are elevated in the patients with urological cancers (39,98) and ovarian cancer (174), the levels of mtDNA are not increased in patients with Ewing sarcoma (173) or breast cancer (77). It is likely that the changes of circulating mtDNA may be dependent on types of cancers or sarcomas.…”

“…The levels of circulating mtDNA are increased in patients with diseases, such as sepsis (82,167), strokes (160), acute liver failure (97), massive pulmonary embolism (4), or cancers (39,98,174), and are also associated with severities or prognosis of the diseases (Table 2). While the levels of circulating mtDNA are elevated in the patients with urological cancers (39,98) and ovarian cancer (174), the levels of mtDNA are not increased in patients with Ewing sarcoma (173) or breast cancer (77).…”

Liquid biopsy in ovarian cancer: recent advances on circulating tumor cells and circulating tumor DNA

“…They found a significant increase in nuclear cfDNA and circulating cell-free mtDNA amounts in ovarian cancer patients compared to both healthy group and benign epithelial tumor patients. Interestingly, they reported a significant difference between ovarian cancer patients and the endometriosis group circulating cell-free mtDNA, but not in nuclear cfDNA [48]. More recently, Choudhuri et al investigated whether nuclear cfDNA and circulating cell-free mtDNA levels can be used for advanced epithelial ovarian cancer diagnosis and for the prediction of treatment response.…”

Generation of blood circulating DNA: the sources, peculiarities of circulation and structure

“…Помимо вирусной ДНК в плазме крови человека многие исследователи не только обнаруживают митохондриальную ДНК [158,159], но и детектируют ВНЕКЛЕТОЧНЫЕ ДНК КРОВИ: ПОЯВЛЕНИЕ И ОСОБЕННОСТИ ЦИРКУЛЯЦИИ в крови онкологических больных характерные для раковых клеток мутации (16S рРНК, район D-петли). Эти мутации были обнаружены при раке легкого, мочевого пузыря, раке предстательной железы, опухолях головы и шеи [132,160].…”