Levels of C-Reactive Protein and Sodium May Differentiate a Perforated Appendix from a Nonperforated Appendix in Children

Nissen, Matthias; Tröbs, Ralf-Bodo

doi:10.1155/2021/9957829

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Negative appendectomy still occurs in 1 to 40% of patients. [3,19]. The rate of complicated appendicitis has been quoted as 20-74%, being even higher in younger children.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

et al. 2021

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Background and Objectives: Acute appendicitis in pediatric patients is one of the most common surgical emergencies, but the early diagnosis still remains challenging. The aim of this study was to determine the predictive value of Red blood cell distribution width (RDW), Mean platelet volume (MPV) and Platelet distribution width (PDW) in children with acute appendicitis. Materials and Methods: This study was a retrospective assessment of laboratory findings (RDW, MPV, PDW) of patients who underwent surgical treatment for acute appendicitis from January 2019 to December 2020. Result: During this period, 223 appendectomies were performed at our Institute. In 107 (43%) cases appendicitis was uncomplicated, while in 116 (46.6%) it was complicated. WBC and RDW/MPV ratio were significant parameters for the diagnosis of acute appendicitis with cut-off values of 12.86 (susceptibility: 66.3%; specificity: 73.2%) and 1.64 (susceptibility: 59.8%; specificity: 71.9%), respectively. WBC and RDW/RBC ratio were independent variables for the diagnosis of complicated appendicitis. The cut-off values were 15.05 for WBC (sensitivity: 60.5%; specificity: 70.7%) and 2.5 for RDW/RBC ratio (sensitivity: 72%; specificity: 52.8%). Conclusions: WBC is an important predictor of appendicitis and complicated appendicitis. RDW, MPV and PDW alone have no diagnostic value in pediatric acute appendicitis or predicting the degree of appendix inflammation. However, the RDW/MPV ratio can be an important predictor of appendix inflammation, with higher values in patients with more severe appendix inflammation. RDW/RBC ratio may be an important predictor of complicated appendicitis.

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“…Negative appendectomy still occurs in 1 to 40% of patients. [3,19]. The rate of complicated appendicitis has been quoted as 20-74%, being even higher in younger children.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

et al. 2021

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“…Consequently, serum biomarkers have gained attention as potential for disease prediction and diagnosis in recent years. Research has highlighted several markers with predictive value for pediatric perforated appendicitis, including the neutrophil-to-lymphocyte ratio 8 , platelet-to-lymphocyte ratio 9 , elevated serum total bilirubin level 10 , increased C-reactive protein (CRP) 11 , decreased serum sodium levels 12 , and elevated erythrocyte sedimentation rate 13 . This study aims to fill this gap by conducting an evaluation of the CRP to prealbumin ratio (CPA) as a potential marker for pediatric perforated appendicitis.…”

Section: Introductionmentioning

confidence: 99%

Pediatric perforated appendicitis diagnosis based on the C-reactive protein/prealbumin ratio

Long,

Zhang,

Chen

et al. 2024

Sci Rep

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Pediatric perforated appendicitis, prone to multiple complications, necessitates identifying potential serum biomarkers for early diagnosis and intervention. A cross-sectional study was conducted on patients under 16 with acute appendicitis, admitted to Hainan Women and Children’s Medical Center from January 2019 to July 2023. The patients were categorized into perforated and non-perforated groups. Among the 313 included patients, 106 (33.87%, 95% CI 28.59–39.14%) developed perforation. The C-reactive protein to prealbumin ratio (CPA) showed a significant difference between the perforated and non-perforated groups [6.63 (2.9–13.02) vs. 0.7 (0.11–2.18), p < 0.001]. The AUC of CPA on the ROC curve was 0.691 (95% CI 0.513–0.869, p = 0.084) in patients under 4. In patients aged 4–9, the sensitivity of CPA > 3 predicting perforation was 76.2%, with a specificity of 81.6%, and an AUC of 0.816 (95% CI 0.747–0.886, p < 0.001). For patients aged 9–16, the sensitivity of CPA > 2.2 predicting perforation was 85%, with a specificity of 85.7%, and an AUC of 0.919 (95% CI 0.859–0.979, p < 0.001). CPA > 3 and CPA > 2.2 can predict perforated appendicitis in patients aged 4–9 and 9–16, respectively.

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Time-Related Parameters in Acute Appendicitis

et al. 2021

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Levels of C-Reactive Protein and Sodium May Differentiate a Perforated Appendix from a Nonperforated Appendix in Children

Cited by 4 publications

References 39 publications

Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

Pediatric perforated appendicitis diagnosis based on the C-reactive protein/prealbumin ratio

Time-Related Parameters in Acute Appendicitis

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