Levels of antibodies against cytomegalovirus and <i>Chlamydophila pneumoniae</i> are increased in early onset pre‐eclampsia

Dadelszen, Peter von; Magee, Laura A.; Krajden, Mel; Alasaly, Kadria; Popovska, Vesna; Devarakonda, Rajashree M.; Money, Deborah; Patrick, David M.; Brunham, Robert C.

doi:10.1111/j.1471-0528.2003.02481.x

Cited by 86 publications

(85 citation statements)

References 38 publications

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“…For example, first-trimester trophoblasts infected with CMV demonstrate reduced cell invasion, increased apoptosis (2, 79), higher expression of proinflammatory cytokines (80), and reduced HLA-G expression (81,82). CMV infection is also associated with fetal growth restriction, spontaneous pregnancy loss (82)(83)(84), and preeclampsia (85,86), all of which are outcomes that can result from insufficient placental development. HSV infection also results in loss of HLA-G (87), cell death, and reduced human chorionic gonadotropin secretion (88).…”

Section: Viral Infections and Early Placental Developmentmentioning

confidence: 99%

Risks associated with viral infections during pregnancy

Racicot¹,

Mor

2017

Journal of Clinical Investigation

238

204

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Section: Viral Infections and Early Placental Developmentmentioning

confidence: 99%

Risks associated with viral infections during pregnancy

Racicot¹,

Mor

2017

Journal of Clinical Investigation

238

204

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“…Association between CMV antibodies in pregnancy and development of preeclampsia is inconsistent. [34][35][36] It has been confirmed the elevated CMV antibodies level 35 and genomic DNA load in women with early onset preeclampsia was reported or confirmed. 37,38 However, Strand et al 39 reported lower anti CMV IgG seropositivity in preeclamptic women than healthy.…”

Section: Discussionmentioning

confidence: 72%

“…The risk for developing preeclampsia was confirmed by others to be associated with increased prevalence of CMV IgG together with increased CMV IgG antibodies level. 34,35 This may be explained by the fact that the increased risk for developing preeclampsia in women with specific HLA-G alleles may be combined with CMV infection. 4 It has been stated that CMV infection impairs trophoblast differentiation and invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Our results agree with other who reported that women with early-onset PE (<34 weeks) have higher IgG HCMV titers than women with late-onset. 35 Moreover, in the placenta, the increased cytokine production especially TH1 profile may be an important component of the immune inflammatory response that impairs trophoblast invasion and results in trophoblast death. 42 The impact, are associated with adverse outcomes that include fetal growth restriction preeclampsia and spontaneous preterm delivery.…”

Section: Discussionmentioning

confidence: 99%

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The possible role of cytomegalovirus infection and pro-inflammatory IL_2 cytokine in preeclampsia

Barzangy

Salh

Hamasaeed

et al. 2018

ZJMS

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IntroductionThe origin of preeclampsia, a hypertensive disorder unique to pregnancy is still a matter of debate and numerous theories have suggested. The pathophysiology of the disease involves impaired trophoblast invasive, abnormal genetic polymorphism, vascular endothelial cell activation, immune tolerance by the maternal immune system and an exaggeration of a systematic inflammatory process. Background and Objective: Fragmentary evidence suggests that trophoblast viral infection may play a role in placental dysfunction leading to complications like Preeclampsia. Among these, placental exposure to CMV induces an inflammatory response that precedes invasive trophoblast cell death. This study aimed to assess the frequency of anti-CMV IgG seropositivity and IL2 level in serum in patients with preeclampsia compared to normotensive control pregnant women. Methods: A total of 90 women were enrolled, of which 60 had preeclampsia and 30 normotensive pregnant women as the control. A serum sample was collected from each subject and was investigated for anti-CMV IgG serostatus and IL-2 concentration using Enzyme-Linked Immunosorbent Assay (ELISA) based kits. Results: In preeclamptic and normotensive pregnant women, 33.3% and 16.6% of the tested sera were seropositive for anti CMV IgG antibodies respectively (P = 0.136). Early onset preeclamptic women revealed a high frequency of anti-CMV seropositivity (80%) when compared with late onset Preeclampsia (20%). Cytokine assessment revealed a higher IL-2 level in preeclamptic women seropositive for anti-CMV IgG although statistically was not significant (P = 0.14), but in normotensive women, the IL-2 level was significantly higher in sera seropositive for anti-CMV IgG (P = 0.02). Conclusion: This study delineates a high frequency of anti-CMV IgG antibodies particularly those with early onset preeclampsia; with no significant difference for the IL-2 level.

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“…[24][25][26][27][28][29][30][31][32][33][34][35] The severity of dysfunction may determine outcome and result in a spectrum of clinical presentations that share a common etiology, with severe dysfunction being associated with miscarriage and lesser dysfunction leading to preeclampsia, intrauterine growth restriction, and a predisposition to PTL. It follows that the spectrum of complications may stem from the same or related triggering factors or conditions, with the extent of complication being proportional to the variation from normal physiological levels of a biological factor (or combination of factors).…”

Section: Etiology Of Pregnancy Complicationsmentioning

confidence: 99%

Eicosanoids as Diagnostics for Preterm Labor

McKirdy¹,

Rice

Mitchell

2013

Reproductive Biology Insights

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Despite continuing significant research efforts and an increasing prevalence of preterm labor (PTL) worldwide, a comprehensive understanding of the mechanisms involved remains to be established; such is the complexity of the interactions involved. Closing the knowledge gaps in this field would afford an opportunity to improve mortality and morbidity rates on a global scale. Early identification of pregnancies at risk of PTL would increase the possibility of delaying birth (where appropriate) prior to initiation of labor. This requires identification of appropriate biomarkers that are readily detectable in easily obtained clinical samples. A family of arachidonic acid metabolites, called eicosanoids. Eicosanoids have shown promise as possible diagnostic biomarkers for PTL. The inherent problems of antibody cross-reactivity in immunoassay methods has, however, resulted in possible misinterpretation of past results. The following mini-review outlines the necessity of such diagnostic targets and the problem with previous research methods and also summarizes recent findings in the field.

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Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre‐eclampsia

Abstract: The anti-CMV and anti-Chl. pneumoniae antibodies were higher in early onset pre-eclampsia than in late onset pre-eclampsia, normotensive IUGR and normal pregnancy. This may provide a pathophysiological link between pre-eclampsia and the known increased risk for subsequent atherosclerosis.

Cited by 86 publications

References 38 publications

Risks associated with viral infections during pregnancy

Risks associated with viral infections during pregnancy

The possible role of cytomegalovirus infection and pro-inflammatory IL_2 cytokine in preeclampsia

Eicosanoids as Diagnostics for Preterm Labor

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