Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD

Bessa, Vasiliki; Loukides, Stelios; Hillas, Georgios; Delimpoura, Vasiliki; Simoes, Davina Camargo Madeira; Kontogianni, Konstantina; Papiris, Spyros; Κostikas, Κonstantinos; Alchanatis, Manos; Bakakos, Petros

doi:10.1016/j.cyto.2012.03.007

Cited by 14 publications

(8 citation statements)

References 37 publications

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“…However, there was no difference in VEGF between stable COPD patients and healthy subjects [13,14] . Elevated VEGF serum levels in COPD patients were reported in 2 other trials [15,16] . Another study demonstrated elevated VEGF serum levels in patients with mild COPD only, though negatively correlating with FEV 1 [17] .…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

Boeck

Mandal²,

Costa³

et al. 2015

Respiration

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Background: Impaired vascular endothelial growth factor (VEGF) signaling causes emphysema in animal models. In chronic obstructive pulmonary disease (COPD) patients, alterations in VEGF tissue expression have been observed. We hypothesize that circulating VEGF may be a biomarker to phenotype COPD patients. Objective: The aim of this study was to investigate VEGF serum levels in stable and exacerbated COPD. Methods: VEGF serum levels as well as parameters of short- and long-term outcome were assessed and analyzed in two COPD cohorts [PROMISE, n = 117; ProCOLD (PC), n = 191]. Results: VEGF serum levels at stable COPD were neither related to forced expiratory volume in 1 s nor to the Modified Medical Research Council dyspnea score, 6-min walking distance or BODE index. There was no association between single VEGF levels and COPD exacerbation frequency or mortality at 1 and 2 years of follow-up. In PC an increase in VEGF over time (ΔVEGF) was associated with the exacerbation frequency as well as the 1- and 2-year hospitalization rate (p = 0.046, 0.009 and 0.006, respectively). Furthermore, in PC ΔVEGF was associated with 1- and 2-year survival (p = 0.009 and 0.041, respectively). Conclusions: Single serum VEGF levels, at stable and exacerbated COPD, were not associated with clinically significant outcomes in COPD. Conversely, the VEGF course seems related to COPD prognosis.

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Section: Discussionmentioning

confidence: 99%

“…Several trials reported elevated serum VEGF in COPD, some of them negatively correlating with FEV 1 , i.e. positively correlating with COPD severity [13,15,16] . Moreover, since the main stimulant of VEGF is hypoxia, via hypoxia-inducible factor [3] , an increase in VEGF serum levels in severer disease seems plausible.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

Boeck

Mandal²,

Costa³

et al. 2015

Respiration

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“…This effect causes plasma to ‘leak’ out into extravascular sites because of hydrostatic pressure gradients (Olivenstein et al , ; Reynolds et al , ; Greiff et al , ). This phenomenon is a very distinctive feature of acute inflammation but is also observed in more chronic diseases such as asthma (Laitinen et al , ; Li and Wilson, ; Innes et al , ; Khor et al , ) and COPD (Hill et al , ; Minakata et al , ; Bessa et al , ).…”

Section: Introductionmentioning

confidence: 93%

Role of EP₂ and EP₄ receptors in airway microvascular leak induced by prostaglandin E₂

Jones

Birrell

Maher

et al. 2016

British J Pharmacology

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Background and PurposeAirway microvascular leak (MVL) involves the extravasation of proteins from post‐capillary venules into surrounding tissue. MVL is a cardinal sign of inflammation and an important feature of airway inflammatory diseases such as asthma. PGE2, a product of COX‐mediated metabolism of arachidonic acid, binds to four receptors, termed EP1–4. PGE2 has a wide variety of effects within the airway, including modulation of inflammation, sensory nerve activation and airway tone. However, the effect of PGE2 on airway MVL and the receptor/s that mediate this have not been described.Experimental ApproachEvans Blue dye was used as a marker of airway MVL, and selective EP receptor agonists and antagonists were used alongside EP receptor‐deficient mice to define the receptor subtype involved.Key ResultsPGE2 induced significant airway MVL in mice and guinea pigs. A significant reduction in PGE2‐induced MVL was demonstrated in Ptger2 −/− and Ptger4 −/− mice and in wild‐type mice pretreated simultaneously with EP2 (PF‐04418948) and EP4 (ER‐819762) receptor antagonists. In a model of allergic asthma, an increase in airway levels of PGE2 was associated with a rise in MVL; this change was absent in Ptger2 −/− and Ptger4 −/− mice. Conclusions and ImplicationsPGE2 is a key mediator produced by the lung and has widespread effects according to the EP receptor activated. Airway MVL represents a response to injury and under ‘disease’ conditions is a prominent feature of airway inflammation. The data presented highlight a key role for EP2 and EP4 receptors in MVL induced by PGE2.

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“…For example, García-Lucio et al showed that the expression of Ang-2 in pulmonary arteries appeared to be increased in COPD patients in comparison to healthy smokers [116]. Similarly, Bessa et al showed increased Ang-2 levels in patients with COPD in induced sputum [117]. Ang-2 was also associated with vascular permeability in COPD patients suggesting that the increase in Ang-2 might stimulate leakage from vessels in COPD [117].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, Bessa et al showed increased Ang-2 levels in patients with COPD in induced sputum [117]. Ang-2 was also associated with vascular permeability in COPD patients suggesting that the increase in Ang-2 might stimulate leakage from vessels in COPD [117]. Interestingly, the levels of Ang-2 in the blood appear to be higher in patients with moderate COPD rather than severe COPD [113].…”

Section: Introductionmentioning

confidence: 99%

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Green

Turner

2017

Respir Res

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COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its’ progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.

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Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD

Cited by 14 publications

References 37 publications

Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

Role of EP₂ and EP₄ receptors in airway microvascular leak induced by prostaglandin E₂

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

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Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD

Cited by 14 publications

References 37 publications

Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

Longitudinal Measurement of Serum Vascular Endothelial Growth Factor in Patients with Chronic Obstructive Pulmonary Disease

Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

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Product

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Role of EP₂ and EP₄ receptors in airway microvascular leak induced by prostaglandin E₂