Levels of  -Aminobutyric Acid in Cerebrospinal Fluid in Various Neurologic Disorders

Decreased CSF Concentrations of Homovanillic Acid and γ-Aminobutyric Acid in Alzheimer's Disease

“…There¬ fore, it can be hypothesized that in dementia the dopaminergic deficiency involves some neuronal system other than the nigrostriatal. The clinical importance of this dopaminergic 36 However, in these latter studies there were no age-matched controls. In our study, although GABA concentrations were low com¬ pared with controls of unselected ages, they were of the same order of magnitude as in their age-matched controls.…”

GABAergic mechanisms in the pathogenesis and treatment of epilepsy.

“…Comparison of tissue from the epileptogenic zone (determined electrographically) with non-epileptogenic tissue showed a decrease in glutamic acid decarboxylase activity in a proportion, but not all, of a group of 27 patients undergoing focal resection (Lloyd et al, 1985). However, Babb (1986) Studies of the GABA content in lumbar CSF have shown a significant reduction in patients with a wide range of epileptic syndromes compared with non-neurological controls, both for adults (Manyam et al, 1980;Wood et al, 1979) and for children Loscher & Siemes, 1985). These data support the concept that diminished GABAergic inhibition contributes to seizure susceptibility.…”

Delayed Postanoxic Encephalopathy After Strangulation Serial Neuroradiological and Neurochemical Studies

“…The T2-and Trweighted MRIs on the 23rd day showed the same lesion, respectively, as high-and lowintensity areas (Fig 3, b repetition time = 400 milliseconds and echo time = 22 milliseconds) on the 23rd day showed the same lesions as fairly lowintensity areas (f). These lesions had become small and even lower in Intensity (g) but were still present 8 …”