Levels of Acute Phase Reactants in Patients with Acute Brucellosis

Ulug, Mehmet; Can-Uluğ, Nuray; Selek, Sahabettın

doi:10.5152/kd.2010.15

Cited by 6 publications

(3 citation statements)

References 6 publications

(6 reference statements)

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“…During the infection, the liver gives absolute priority to α and β globulins synthesis at the expense of albumin synthesis causing the significant hypoalbuminemia recorded in both diseased groups. Similar results were obtained by Uluğ et al (2010), Kumar et al (2015), Mahboub et al (2015), and Hashem et al (2020) in brucella-infected humans, ewes, and cows respectively.…”

Section: Discussionsupporting

confidence: 85%

Clinicopathological Studies on Brucellosis in Sheep and Goat at Matrouh Governorate, Egypt

Darwish¹,

Mahmoud²,

El-Kattan³

2022

JAHP

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A t Matrouh governorate (western gate of Egypt), sheep and goat breeding is a basic part of the socio-economic life, due to the nature of the governorate as a semiaired area and the ability of these breeds to endure the drought and dry conditions. Matrouh is located near the Libyan border, and there is uncontrolled animal movement between the two countries, and political unrest in Libya facilitated the spreading of transboundary diseases into Matrouh. Among these diseases brucellosis, which is a worldwide problem, not only as a veterinary problem but also as a health issue for humans. It ranked as the second zoonotic disease after rabies. In Egypt, it is an endemic disease. Different species of Brucella were isolated from

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Section: Discussionsupporting

confidence: 85%

Clinicopathological Studies on Brucellosis in Sheep and Goat at Matrouh Governorate, Egypt

Darwish¹,

Mahmoud²,

El-Kattan³

2022

JAHP

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“…The purpose of the acute phase response is to neutralize pathogens by isolating them, to reduce tissue damage to a minimum by limiting them, to prevent the generalization of the events, to start the repair, thereby allowing the host hemostatic mechanisms to restore the normal physiological function in a fast manner. [25] AA causes the initiation of an inflammatory process secondary to bacterial infection in the body, resulting in the formation of an acute phase response by organism against the pathogen. Regardless of the localized or generalized nature of the disease, the acute phase response is a general host reaction.…”

Section: Discussionmentioning

confidence: 99%

The value of inflammatory markers in diagnosing acute appendicitis in pregnant patients

Akbaş

Kasap

Hacım

et al. 2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute appendicitis (AA) is the most common extra-obstetric condition requiring surgery during pregnancy. AA diagnosis is made by laboratory tests along with anamnesis and physical examination findings. Due to the physiological and anatomical changes during the pregnancy, AA diagnosis is more challenging in pregnant women compared to non-pregnant patients. The present study evaluated the significance of white blood cell counts (WBC), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CAR) and lymphocyte-to-C-reactive protein ratio (LCR) to diagnose acute appendicitis during pregnancy. METHODS:Pregnant patients admitted to General Surgery Inpatient Clinic with AA pre-diagnosis in September 2015-December 2019 period were screened using International Statistical Classification of Diseases and Related Health Problems-10 (ICD-10) diagnosis code (K35= acute appendicitis, Z33= pregnancy), and AA patients were identified retrospectively. The patients were divided into two groups. The Group I included the patients who had appendectomy due to AA and had a suppurative appendicitis diagnosis based on the pathological evaluation. On the other hand, Group II had the patients admitted as an inpatient with AA pre-diagnosis, but discharged from the hospital with full recovery without operation. Group III, i.e., the control group, on the other hand, was constituted by 32 randomly and prospectively recruited healthy pregnant women who were willing to participate in the study and who had matching study criteria among the patients followed in Obstetrics and Gynecology outpatient clinic of our hospital. RESULTS:This study included 96 pregnant women with an average age of 29.20±4.47 years (32 healthy pregnant women, 32 pregnant women followed for acute abdominal observation and 32 pregnant women who underwent appendectomy). Of these patients, three cases who turned out not to have suppurative appendicitis (negative appendectomy) and two cases found to have perforated appendicitis based on intraoperative and histopathological evaluations were excluded from this study. The results showed that Group I patients had significantly higher WBC (p=0.001), CAR (p=0.001) and NLR (p=0.001), but significantly lower LCR values (p=0.001) compared to the Groups II and III. Besides, based on logistic regression analysis, it was revealed that higher WBC, CAR and NLR values and lower LCR values were independent variables that could be used for the diagnosis of AA in pregnant women. CONCLUSION:Considering WBC, NLR, CAR and LCR parameters in addition to medical history, physical examination and imaging techniques could help clinicians diagnose acute appendicitis in pregnant women.

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“…CRP, ESR, albumin, and fibrinogen are acute phase reactants. These levels peak at 6-36, 24-48, and 24-72 hours from onset of disease, respectively (34)(35)(36). Albumin is a negative acute phase reactant (35).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelet Parameters and Acute Phase Reactants in Pediatric Patients Presenting with Fever

Bucak¹,

Almış²,

Turğut³

2019

J Pediatr Inf

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Ateşin artmasının viral ve bakteriyel ajanların üremesini baskıladığı ve vücudun akut faz yanıtını desteklediği gösterilmiştir. Akut faz reaktanları, trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım genişliği ve plateletkrit gibi tüm parametrelerin viral ve bakteriyel enfeksiyonları seyrinde değişebilmektedir. Bu çalışmada çocukluk çağında ateş şikayeti ile başvuran hastalarda platelet parametreleri ve akut faz belirteçlerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Polikliniğe ateş nedeniyle başvuran hastalar çalışmaya dahil edildi. Hastalar ateş sürelerine göre üç gruba ayrıldı; Grup 1 < 24 saat, Grup 2 24-48 saat ve Grup 3 > 48 saat. Kontrol grubu hastaları ateşi olmayan ancak hasta çocuklardan seçildi. Ortalama trombosit hacmi, trombosit dağılım genişliği, plateletkrit, trombosit sayısı, eritrosit sedimentasyonu ve fibrinojen her hasta için incelendi. Bulgular: Çalışmaya 272 hasta dahil edildi. Gruplar arasında trombosit dağılım genişliği, plateletkrit ve trombosit sayısı açısından istatistiksel olarak anlamlı fark yoktu. Ancak, ortalama trombosit hacmi, eritrosit sedimentasyon hızı, C-reaktif protein, fibrinojen ve albumin açısından gruplar arasında istatistiksel olarak anlamlı fark vardı. Sonuç: Akut faz belirteçleri ve ortalama trombosit hacmi ateş süresinden etkilenmektedir.

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Levels of Acute Phase Reactants in Patients with Acute Brucellosis

Cited by 6 publications

References 6 publications

Clinicopathological Studies on Brucellosis in Sheep and Goat at Matrouh Governorate, Egypt

Clinicopathological Studies on Brucellosis in Sheep and Goat at Matrouh Governorate, Egypt

The value of inflammatory markers in diagnosing acute appendicitis in pregnant patients

Evaluation of Platelet Parameters and Acute Phase Reactants in Pediatric Patients Presenting with Fever

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