Levels of a mixture of heavy metals in blood and urine and all-cause, cardiovascular disease and cancer mortality: A population-based cohort study

Duan, Weiwei; Xu, Cheng; Liu, Qian; Xu, Jin; Weng, Zhenkun; Zhang, Xin; Basnet, Til Bahadur; Dahal, Maginsh; Gu, Aihua

doi:10.1016/j.envpol.2020.114630

Cited by 122 publications

(55 citation statements)

References 80 publications

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“…In recent years, with the rapid development of industries and cities in China, harmful heavy metals such as nickel, cadmium, and lead ions have been discharged into the groundwater, along with mining, metallurgy, chemical, electronics, electroplating and other industries [ 1 , 2 , 3 , 4 ], causing serious pollution to the water environment. Since heavy metal ions are not degradable in the water environment, they will pose a serious threat to human health through the enrichment of the food chain [ 5 , 6 , 7 , 8 ]. Among them, lead ion cannot be easily removed once they enter the environment.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Lead Ion from Wastewater Using Non-Crystal Hydrated Calcium Silicate Gel

et al. 2021

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In order to obtain low-cost and excellent adsorption materials, this paper used calcium acetate and water glass as raw materials to synthesis hydrated calcium silicate gel by precipitation method. The performance and structure of hydrated calcium silicate gel were systematically studied by X-ray photoelectron spectroscopy, fourier transform infrared spectroscopy, specific surface area analyzer and scanning electron microscope. Studies have shown that, non-crystal hydrated calcium silicate gel (CSH) were successfully prepared, and the removal rate of lead ion using CSH reached more than 90%. The adsorption process is consistent with the pseudo-second-order kinetic model and Langmuir adsorption isotherm model, and the limit adsorption capacity reaches 263.17 mg·g−1. The acid treatment experiment proved that the adsorption capacity of lead ion using CSH was satisfactory, and the adsorption rate remained at >60% after 5 cycles. The research may provide a low-cost, high-efficiency and high stability adsorbent.

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Section: Introductionmentioning

confidence: 99%

Adsorption of Lead Ion from Wastewater Using Non-Crystal Hydrated Calcium Silicate Gel

et al. 2021

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“…To illustrate, a recent study found that exposure to a mixture of heavy metals is positively associated with cancer mortality, as well as all-cause mortality. In fact, this study implicated cadmium as having the highest contribution to this, which is highly relevant given cadmium was identified as a pollutant of concern on Staten Island [34]. Furthermore, a study in Italy highlighted that patients with head and neck cancer, including thyroid cancer, were more likely to have both elevated levels of heavy metal ions, such as cadmium and arsenic, and PCBs compared to their healthy counterparts [35].…”

Section: Discussionmentioning

confidence: 79%

High Thyroid Cancer Incidence Rate in a Community near a Landfill: A Descriptive Epidemiological Assessment

Gerwen

Gold

Alsen

et al. 2021

Toxics

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Background: to investigate the high thyroid cancer incidence rate of Staten Island and to disentangle the effects of potential environmental exposure from a landfill from screening. Methods: age-adjusted thyroid cancer incidence rates obtained from the New York State Public Access Cancer Epidemiology Data for New York State (NYS) excluding New York City (NYC) and the five NYC boroughs, including Staten Island, were mapped over time (1995–2018), investigated per age group and by percentage of localized thyroid cancer. Changes in trends were assessed using joinpoint. Contaminants of concern on Staten Island were assessed for carcinogenic and endocrine disruptive properties. Results: a more pronounced thyroid cancer incidence rate increase, without a difference in age distribution and similar percentages of localized thyroid cancer, was found in Staten Island compared to its demographic equivalent (NYS excluding NYC). Multiple contaminants of concern with carcinogenic and endocrine disrupting properties (e.g., cadmium, lead) were identified in air, water and sediment samples. Conclusion: investigations into the effects of increased/sustained environmental exposures are needed in chronically exposed populations to identify potential mechanisms of action of certain pollutants.

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“…PAHs (Schober et al, 2007) and VOCs such as toluene and benzene (Jiménez- Garza et al, 2017) are also known to elicit an inflammatory response individually and in combination (Kuang et al, 2020). Heavy metals have been recently linked to cardiovascular disease (Duan et al, 2020). Tobacco exposures have been causal factors in several noncancer effects such as respiratory problems (Anderson & Ferris Jr, 1962), heart disease (Lakier, 1992), infections (Arcavi & Benowitz, 2004), and fertility problems (Stillman et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Identification of occupations susceptible to high exposure and risk associated with multiple toxicants in an observational study: National Health and Nutrition Examination Survey 1999-2014

Nguyen

Colacino

Patel

et al. 2021

Preprint

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BackgroundAccording to the World Health Organization, occupational exposures to hazardous chemicals are estimated to cause over 370,000 premature annual deaths. The risks due to multiple workplace chemical exposures, and those occupations most susceptible to the resulting health effects, remain poorly characterized.ObjectivesThe aim of this study is to identify occupations with elevated toxicant biomarker concentrations and increased health risk associated with toxicant exposures in a working US population from diverse categories of occupation. More specifically, we aim to 1) define differences in chemical exposures based on occupation description, 2) identify occupational groups with similar chemical exposure profiles, and 3) identify occupational groups with chemical biomarker levels exceeding acceptable health-based biomarker levels.MethodsFor this observational study of 51,008 participants, we used data from the 1999-2014 National Health and Nutrition Examination Survey. We characterized differences in chemical exposures by occupational group for 129 chemicals by applying a series of generalized linear models with the outcome as biomarker concentrations and the main predictor as the occupational groups, adjusting for age, sex, race/ethnicity, poverty income ratio, study period, and biomarker of tobacco use. We identified groups of occupations with similar chemical exposure profiles via hierarchical clustering. For each occupational group, we calculated percentages of participants with chemical biomarker levels exceeding acceptable health-based guidelines.ResultsBlue collar workers from “Construction”, “Professional, Scientific, Technical Services”, “Real Estate, Rental, Leasing”, “Manufacturing”, and “Wholesale Trade” have higher biomarker levels of toxic chemicals such as several heavy metals, acrylamide, glycideamide, and several volatile organic compounds compared to their white-collar counterparts. For these toxicants, 1-58% of blue-collar workers from these industries have toxicant concentrations exceeding acceptable levels.DiscussionBlue collar workers have toxicant levels higher relative to their white-collar counterparts, often exceeding acceptable levels associated with noncancer effects. Our findings identify multiple occupations to prioritize for targeted interventions and health policies to monitor and reduce high toxicant exposures.

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Levels of a mixture of heavy metals in blood and urine and all-cause, cardiovascular disease and cancer mortality: A population-based cohort study

Cited by 122 publications

References 80 publications

Adsorption of Lead Ion from Wastewater Using Non-Crystal Hydrated Calcium Silicate Gel

Adsorption of Lead Ion from Wastewater Using Non-Crystal Hydrated Calcium Silicate Gel

High Thyroid Cancer Incidence Rate in a Community near a Landfill: A Descriptive Epidemiological Assessment

Identification of occupations susceptible to high exposure and risk associated with multiple toxicants in an observational study: National Health and Nutrition Examination Survey 1999-2014

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