Levels in the U.S. Population of those Persistent Organic Pollutants (2003−2004) Included in the Stockholm Convention or in other Long-Range Transboundary Air Pollution Agreements

Patterson, Donald G.; Wong, Lee Yang; Turner, Wayman E.; Caudill, Samuel P.; DiPietro, Emily S.; McClure, Patricia C.; Cash, Troy P.; Osterloh, John; Pirkle, James L.; Sampson, Eric J.; Needham, Larry L.

doi:10.1021/es801966w

Cited by 187 publications

(152 citation statements)

References 19 publications

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“…16 However, median levels were somewhat lower in our study for other analytes including PCB 180 (33.7 vs 49.6). Per the inclusion criteria of the parent study, the 109 women in our study (Table 2) were postmenopausal (mean age 60.6 years) and overweight or obese (mean BMI 30.3).…”

Section: Resultscontrasting

confidence: 70%

Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations

Roos

Ulrich

Sjödin

et al. 2012

J Expo Sci Environ Epidemiol

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We investigated cross-sectional associations of body composition and weight change with polychlorinated biphenyls (PCB) and organochlorine pesticides/pesticide metabolites measured in blood collected at the baseline of the Physical Activity for Total Health study of postmenopausal, overweight women living in the Seattle, Washington metropolitan area. Indicators of greater adiposity were associated with lower plasma concentrations of most PCBs with six or more chlorine atoms. This pattern was observed for current weight, body mass index, fat mass percent, subcutaneous abdominal fat, intra-abdominal fat, waist circumference, hip circumference, waist-to-hip ratio, and maximum adult weight. Conversely, PCB 105, PCB 118, and p,p 0 -DDE were generally increased or showed no association with these variables. Weight gain since age 35 was associated with lower concentrations of almost every organochlorine we studied, and past weight loss episodes of at least 20 pounds (Z9.1 kg) were associated with higher concentrations. Our results have implications for epidemiologic studies of organochlorines in terms of covariates that may be important to consider in statistical analyses, particularly as such considerations may differ importantly by specific analyte. Our finding of increased organochlorine concentrations with past weight loss episodes may have public health significance; however, this association requires confirmation in longitudinal studies.

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Section: Resultscontrasting

confidence: 70%

Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations

Roos

Ulrich

Sjödin

et al. 2012

J Expo Sci Environ Epidemiol

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“…Persistent Organic Pollutants are widespread amongst the American public. A considerable number of POPs have been detected in the tissues of those studied [88].…”

Section: Persistent Organic Pollutantsmentioning

confidence: 96%

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet

Strombom¹,

Rose²

2017

EMIJ

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Those following a plant-based diet have a 78% reduction risk of Type II diabetes mellitus (T2DM), as well as a 56% reduced risk of metabolic syndrome and a lower average BMI, 22.4 for men and 21.8 for women. Vegetarians have less skeletal intramyocellular lipids, and better myocellular glucose disposal and mitochondrial function, and therefore have less peripheral insulin resistance. Vegetarians and vegans also have a much better inflammatory status, indicated by lower levels of inflammatory markers such as CRP and inflammatory adipocytokines such as IL-6, leptin, and higher levels of anti-inflammatory adipocytokines such as adiponectin. Those following a plant-based diet consume much less persistent organic pollutants (POPs) which have been shown to cause beta-cell mitochondrial dysfunction. Finally, the gut microbiome of vegetarians has been shown to play a role in reducing insulin resistance and the level of inflammation in the body, and consequently their risk of T2DM. Interventional studies show a reduction of HbA1C by as much as 2.4 percentage pts, which is more than is usually achieved with Metformin. Other clinical variables also show improvement such as reductions in BMI, total and LDL cholesterol and hsCRP. Studies show compliance rates are good, ranging from 84% to 99%. Medications should be titrated as the patient shows improvements. Treatment with a plantbased diet has no contraindications or adverse reactions. Keywords:

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“…This makes it difficult to identify the concentrations of the POPs and their influences on the human body and also analyses of the population distribution of the concentrations of a given compound tend to reveal that individuals have a lower amount of POPs when compared to certain minority population (NRC (National Research Council), 2006;DHHS, 2009;Porta et al, 2008;Thornton et al, 2002;Health Canada, 2010;Patterson et al, 2009;Porta et al, 2010). Therefore, it is vital that the entire population distribution is analyzed for the concentrations of the numerous environmental chemicals as recommended by the committee from the National Research Council (NRC, 2006).…”

Section: Monitoring Human Exposure To Popmentioning

confidence: 99%

“…However, the concentration levels of individual compounds along with the number of compounds detected per person are routinely reported, with a greater emphasis on the former as the latter information may not be accurate primarily due to the fact that it does not account for the corresponding concentrations and is hence misleading (DHHS, 2009;Woodruff et al, 2011;Porta et al, 2010;Health Canada, 2010;Thornton et al, 2002 andPatterson et al, 2009). However, even a chemical by chemical analysis does not tackle the issue of multiple chemical concentrations along with the POPs (Kortenkamp et al, 2009;Gladen et al, 2003;Porta et al, 2008).…”

Section: Monitoring Human Exposure To Popmentioning

confidence: 99%

Review of Environmental and Human Exposure to Persistent Organic Pollutants

Jacob¹,

Cherian²

2013

ASS

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Persistent Organic Pollutants (POPs) have a very long life and they persist in the environment for a very long time and have a long life in soils, sediments, air or biota. There has been a recent upsurge of interest in the development of low cost reliable measures which are required in order to detect and trace current concentration levels of persistent organic pollutants (POPs) as a result of increasing levels of accumulation within the living organism, transformation as well as toxicity making it ideal to examine the impact on the environment which has been the focus of this review. There are still debates that rage around the issue including relevance of some physio pathologic effects of POPs on the human body along with epidemiological and clinical effects on the human population. Hence in this review there is examination, debating and presenting of arguments in relation to the sources, properties and types of POPs in the atmosphere along with examining the toxicity, analytical techniques and monitoring of atmospheric and biological concentration of POPs in the human population.

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Levels in the U.S. Population of those Persistent Organic Pollutants (2003−2004) Included in the Stockholm Convention or in other Long-Range Transboundary Air Pollution Agreements

Cited by 187 publications

References 19 publications

Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations

Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations

The Prevention and Treatment of Type 2 Diabetes Mellitus with a Plant-Based Diet

Review of Environmental and Human Exposure to Persistent Organic Pollutants

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