Levels and distribution of organochlorine pollutants in primary dental tissues and bone of lamb

Jan, Janja; Uršič, Matjaž; Vrecl, Milka

doi:10.1016/j.etap.2013.09.005

Cited by 6 publications

(19 citation statements)

References 35 publications

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“…From the detailed search, we found 14 articles that measured organic chemicals in tooth bio-matrix. In Table 1, we summarize these studies, providing key details of exposure source, detection rate, and concentrations of the organic chemicals detected in teeth (Camann et al, 2013; Cattaneo et al, 2003; Fos P, 2011; Garcia-Algar et al, 2003; Jan et al, 2006; Jan et al, 2013; Jan and Vrbic, 2000; Jan et al, 2001; Kanjanawattana et al, 2001; Marchei et al, 2008; Pascual et al, 2003; Pellegrini et al, 2006; Schussl et al, 2014; Zeren et al, 2013). These studies ranged from (i) intentional drug abuse (Cattaneo et al, 2003; Pellegrini et al., 2006), (ii) environmental exposures (Garcia-Algar et al, 2003; Pascual et al., 2003), (iii) clinical administration (Fos P, 2011; Schussl et al., 2014) and (iv) personal habits of alcohol consumption (Zeren et al, 2013).…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…These studies ranged from (i) intentional drug abuse (Cattaneo et al, 2003; Pellegrini et al., 2006), (ii) environmental exposures (Garcia-Algar et al, 2003; Pascual et al., 2003), (iii) clinical administration (Fos P, 2011; Schussl et al., 2014) and (iv) personal habits of alcohol consumption (Zeren et al, 2013). These studies have used teeth from human children (Camann et al, 2013; Garcia-Algar et al, 2003; Jan and Vrbic, 2000; Marchei et al, 2008; Pascual et al, 2003), adults (Fos P, 2011; Schussl et al, 2014; Zeren et al, 2013) and deceased people (Cattaneo et al, 2003), as well as from animals (Jan et al, 2006; Jan et al, 2013; Jan et al., 2001; Kanjanawattana et al, 2001) (Table 1). The tooth bio-matrix has been successfully analyzed for the presence of numerous organics classes e.g.…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…The tooth bio-matrix has been successfully analyzed for the presence of numerous organics classes e.g. organochlorines (Jan et al, 2006; Jan et al, 2013; Jan and Vrbic, 2000; Jan et al, 2001), anesthetics (Kanjanawattana et al, 2001), illegal drugs (Kanjanawattana et al, 2001; Pellegrini et al, 2006), tobacco (Marchei et al, 2008; Pascual et al, 2003; Pichini et al, 1997), analgesics, pesticides and plastics additives (Camann et al, 2013), alcohol (Zeren et al, 2013), and antibiotics (Fos P, 2011; Schussl et al., 2014) (Table 1). Reported methodologies for extraction and analysis of organic chemicals in teeth are complex.…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…For deciduous/baby teeth, collection typically occurred upon natural shedding (Camann et al, 2013; Garcia-Algar et al, 2003; Marchei et al, 2008; Pascual et al, 2003), while in other studies teeth were extracted because of dental disease (Jan and Vrbic, 2000; Pellegrini et al, 2006; Schussl et al, 2014) or for the purpose of the study in animals (Fos P, 2011; Jan et al, 2006; Jan et al, 2013; Jan et al, 2001; Kanjanawattana et al, 2001; Zeren et al, 2013), and in certain cases after death (Cattaneo et al, 2003) (Table 2). Benefits of collecting naturally shed teeth include non-invasive bio-matrix collection and these teeth cover the prenatal period whereas only the first molar in permanent teeth start forming before or near birth.…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

“…Pulverization was carried out with a high energy mini bead-beater (Zeren et al., 2013) or a ceramic mill (Cattaneo et al, 2003), ball mill (Garcia-Algar et al, 2003; Marchei et al, 2008; Pascual et al, 2003; Pellegrini et al, 2006), bone mill (Schussl et al, 2014), or pestle (Jan et al, 2006; Jan et al, 2013; Jan and Vrbic, 2000; Jan et al, 2001). Powdered tooth samples were dried over phosphorus pentoxide by a particular research group (Jan et al, 2006; Jan et al, 2013; Jan et al, 2001). While the common practice was to store the pulverized sample at room temperature, teeth were also reported to be frozen with liquid nitrogen and stored at −80°C either prior to sample preparation (Fos P, 2011; Kanjanawattana et al, 2001) or after pulverization (Schussl et al, 2014).…”

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

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Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Andra

Austin

Arora

2015

Environmental Research

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Epidemiological evidence supports associations between prenatal exposure to environmental organic chemicals and childhood health impairments. Unlike the common choice of biological matrices such as urine and blood that can be limited by short half-lives for some chemicals, teeth provide a stable repository for chemicals with half-life in the order of decades. Given the potential of the tooth bio-matrix to study long-term exposures to environmental organic chemicals in human biomonitoring programs, it is important to be aware of possible pitfalls and potential opportunities to improve on the current analytical method for tooth organics analysis. We critically review previous results of studies of this topic. The major drawbacks and challenges in currently practiced concepts and analytical methods in utilizing tooth bio-matrix are (i) no consideration of external (from outer surface) or internal contamination (from micro odontoblast processes), (ii) the misleading assumption that whole ground teeth represent prenatal exposures (latest formed dentine is lipid rich and therefore would absorb and accumulate more organic chemicals), (iii) reverse causality in exposure assessment due to whole ground teeth, and (iv) teeth are a precious bio-matrix and grinding them raises ethical concerns about appropriate use of a very limited resource in exposure biology and epidemiology studies. These can be overcome by addressing the important limitations and possible improvements with the analytical approach associated at each of the following steps (i) tooth sample preparation to retain exposure timing, (ii) organics extraction and pre-concentration to detect ultra-trace levels of analytes, (iii) chromatography separation, (iv) mass spectrometric detection to detect multi-class organics simultaneously, and (v) method validation, especially to exclude chance findings. To highlight the proposed improvements we present findings from a pilot study that utilizes tooth matrix biomarkers to obtain trimester-specific exposure information for a range of organic chemicals.

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Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

Section: Literature Review: Methodological Aspects Of Organic Chemmentioning

confidence: 99%

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Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Andra

Austin

Arora

2015

Environmental Research

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Alterations in geometry, biomechanics, and mineral composition of juvenile rat femur induced by nonplanar PCB‐155 and/or planar PCB‐169

Brankovič

Jovanovski

Jevnikar

et al. 2016

Environmental Toxicology

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Exposure to widespread lipophilic and bioaccumulative polychlorinated biphenyls (PCBs) induces diverse biochemical and toxicological responses in various organs, including the bone. The aim of this study was to evaluate the changes in growth rate, geometry, serum, and bone biochemical parameters and biomechanics of juvenile rat femur induced by lactational exposure to nonplanar PCB-155 and planar PCB-169 individually and in combination. Fifteen lactating Wistar rats were divided into four groups (PCB-169, PCB-155, PCB-155+169, and control), and PCBs were administered intraperitoneally at different time points after delivery. Femurs from 22-day-old offspring were analyzed by microCT, three-point bending test and inductively coupled plasma-mass spectrometry (ICP-MS) to obtain data on bone geometry, biomechanics and mineral composition. The serum levels of calcium, phosphate and alkaline phosphatase were also determined. Lactational exposure to planar PCB-169 resulted in shorter and thinner femurs, reduced endosteal and periosteal perimeters, smaller total cross-sectional and medullary areas, and lowered serum bone marker levels and calcium levels in the bone, while femur mechanical properties were not significantly altered. The changes observed in the combination exposure (PCB-155+169) group were similar to those observed in the PCB-169 group but were less pronounced. In summary, our results demonstrate that alterations in lactationally exposed offspring were primarily induced by planar PCB-169. The milder outcome in the combined group suggested that the PCB-169-mediated toxic effects on the bone might be reduced by a nonplanar PCB-155 congener. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1135-1146, 2017.

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Environmental Factors and Enamel/Dentin Defects

Babajko¹,

Besten²

2021

Extracellular Matrix Biomineralization of Dental Tissue Structures

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Levels and distribution of organochlorine pollutants in primary dental tissues and bone of lamb

Cited by 6 publications

References 35 publications

Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities

Alterations in geometry, biomechanics, and mineral composition of juvenile rat femur induced by nonplanar PCB‐155 and/or planar PCB‐169

Environmental Factors and Enamel/Dentin Defects

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