Levels and determinants of adipose tissue cadmium concentrations in an adult cohort from Southern Spain

Echeverría, Ruth; Vrhovnik, Petra; Salcedo‐Bellido, Inmaculada; Iribarne-Durán, L.M.; Fiket, Željka; Dolenec, Matej; Martín‐Olmedo, Piedad; Olea, Nicolás; Arrebola, Juan Pedro

doi:10.1016/j.scitotenv.2019.03.114

Cited by 27 publications

(14 citation statements)

References 68 publications

(51 reference statements)

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“…We suggest that measures to limit the exposure of paediatric recipients of blood products to heavy metals and other pollutants should be evaluated by the appropriate regulatory bodies. The present work and several other studies have shown that blood levels of environmental pollutants tend to increase with the individual's age in cross‐sectional studies . Selecting young donors for transfusions to infants may therefore be a feasible approach to reduce the risk of adverse health effects.…”

Section: Discussionsupporting

confidence: 55%

“…Another possible explanation of gender differences in cadmium concentrations may be different lifestyle and diet habits. Smoking and diet are known sources of cadmium exposure . Population studies showed that Norwegian women smoke at least as much as men .…”

Section: Discussionmentioning

confidence: 99%

“…Studies in other European populations showed the same gender difference in cadmium concentrations and possible association with sex hormones in women. 49,50 Another possible explanation of gender differences in cadmium concentrations may be different lifestyle and diet habits.…”

Section: Discussionmentioning

confidence: 99%

“…Smoking and diet are known sources of cadmium exposure. [49][50][51] Population studies showed that Norwegian women smoke at least as much as men. 52,53 Unfortunately, we do not have data on smoking and diet for our study population to test this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

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Environmental pollutants in blood donors: The multicentre Norwegian donor study

Averina

Hervig

Huber

et al. 2020

Transfusion Medicine

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Objectives The aim of this study was to measure blood concentrations of environmental pollutants in Norwegian donors and evaluate the risk of pollutant exposure through blood transfusions. Background Transfused blood may be a potential source of exposure to heavy metals and organic pollutants and presents a risk to vulnerable patient groups such as premature infants. Methods/Materials Donors were randomly recruited from three Norwegian blood banks: in Bergen, Tromsø and Kirkenes. Selected heavy metals were measured in whole blood using inductively coupled plasma mass spectrometry (ICP‐MS), and perfluoroalkyl substances (PFAS) were measured in serum by ultrahigh‐pressure liquid chromatography coupled with a triple‐quadrupole mass spectrometer (UHPLC‐MS/MS). Results Almost 18% of blood donors had lead concentrations over the limit suggested for transfusions in premature infants (0.09 μmol/L). About 11% of all donors had mercury concentrations over the suggested limit of 23.7 nmol/L. Cadmium was higher than the limit, 16 nmol/L, in 4% of donors. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations were over the suggested limit of 0.91 ng/mL in 68% and 100% of the donors, respectively. PFAS concentrations and heavy metal concentrations increased with donor's age. Conclusion A considerable percentage of donors had lead, PFOS and PFOA concentrations over the suggested limits. In addition, at each study site, there were donors with high mercury and cadmium concentrations. Selecting young donors for transfusions or measurements of pollutants in donor blood may be a feasible approach to avoid exposure through blood transfusions to vulnerable groups of patients such as premature infants.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Environmental pollutants in blood donors: The multicentre Norwegian donor study

Averina

Hervig

Huber

et al. 2020

Transfusion Medicine

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“…In this regard, the presence of bisphenol A, parabens and benzophenones in WAT of adults has been reported by our group and others 14 15. Other chemicals not previously studied in WAT such as heavy metals have recently been quantified by our team 16. In addition, overlooked chemicals such as bisphenol F diglycidyl ether,17 a structural analogue of bisphenol A diglycidyl ether, have also been quantified in human WAT at considerable concentrations, with poorly understood consequences for human health 17.…”

Section: Matrix For Exposure Assessmentmentioning

confidence: 60%

How polluted is your fat? What the study of adipose tissue can contribute to environmental epidemiology

Mustieles

Arrebola

2020

J Epidemiol Community Health

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The study of the potential contribution of low-dose exposure to environmental chemicals on the development of chronic conditions in human populations is often hampered by methodological issues, including exposure misclassification and the inability to assess biological effects in target organs. White adipose tissue (WAT) presents the unique feature of being both an advantageous matrix for assessing long-term exposure to mixtures of persistent organic pollutants and an interesting tissue to investigate early preclinical effects. Moreover, other lipophilic non-persistent chemicals and heavy metals have been recently quantified in fat, suggesting that human WAT contains chemical mixtures more complex than initially thought. However, WAT has been scarcely used in environmental epidemiology due to collection difficulties. In this essay we discuss the potential of using human WAT as a source of both exposure and effect biomarkers, with the aim of advancing the epidemiological research of obesity-related diseases, including metabolic syndrome and cancer. Overall, we discuss the implications of investigating WAT in a multidisciplinary framework combining toxicological and epidemiological knowledge in order to improve the inference of causal relationships in observational settings. We finalise by suggesting feasible designs and scenarios in which WAT samples may be reasonably collected.

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Cadmium: An Emerging Role in Adipose Tissue Dysfunction

et al. 2021

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Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and is linked with endocrine disruption, carcinogenicity, diabetes-related diseases, and metabolic disorder. One of the main characterizations of Cd is bioaccumulation where its half-life reaches 40 years with an unknown biological role. Several organs were found to be targets for Cd accumulation such as the liver, kidneys, and adipose tissue. Adipose tissue (AT) is a dynamic organ that plays a significant role in the body’s homeostasis through the maintenance of energy storage. Another vital function for AT is the secretion of adipokines which provides a metabolic cross-talk with the whole body’s organs. Cd is found to adversely impact the function of AT. This includes the disruption of adipogenesis, lipogenesis, and lipolysis. As a consequence, dysfunctional AT has disruptive patterns of adipokines secretions. The main adipokines produced from AT are leptin and adiponectin. Both were found to be significantly declined under the Cd exposure. Additionally, adipose tissue macrophages can produce either anti-inflammatory markers or pro-inflammatory markers depending on the local AT condition. Cadmium exposure was reported to upregulate pro-inflammatory markers and downregulate anti-inflammatory markers. However, the exact mechanisms of Cd’s adverse role on AT structure, function, and secretion patterns of adipokines are not totally clarified. Therefore, in this review, we present the current findings related to Cd detrimental effects on adipose tissues.

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Levels and determinants of adipose tissue cadmium concentrations in an adult cohort from Southern Spain

Cited by 27 publications

References 68 publications

Environmental pollutants in blood donors: The multicentre Norwegian donor study

Environmental pollutants in blood donors: The multicentre Norwegian donor study

How polluted is your fat? What the study of adipose tissue can contribute to environmental epidemiology

Cadmium: An Emerging Role in Adipose Tissue Dysfunction

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