Leveling the playing field: The utility of coronary artery calcium scoring in cardiovascular risk stratification in South Asians

Agarwala, Anandita; Patel, Jaideep; Blaha, Michael; Cainzos‐Achirica, Miguel; Nasir, Khurram; Budoff, Matthew J.

doi:10.1016/j.ajpc.2022.100455

Cited by 6 publications

(3 citation statements)

References 55 publications

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“…Similarly, a study by Chung et al [16] discovered that greater LDL concentrations and triglycerides were independently related to a greater Ca score in a Korean population. Another research by Agarwala et al [17] revealed that lower HDL concentrations were significantly related to a higher coronary artery calcium score in a South Asian population. Furthermore, a study by Kim et al [18] discovered that greater concentrations of triglycerides were significantly related to a higher coronary artery calcium score.…”

Section: Discussionmentioning

confidence: 94%

Correlation between Coronary Calcium Score and Lipid Profile

Nammour¹,

Arafa²,

Attia³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Coronary artery disease (CAD) is a prevalent symptom of cardiovascular disease, which is a major worldwide health problem. Dyslipidemia, characterized by aberrant lipid levels, significantly contributes to CAD development and progression. Objective: This study aimed to investigate whether a correlation exists between dyslipidemia, as assessed by lipid profile parameters, and CAC in individuals presenting with chest pain and a low to intermediate PTP for CAD, utilizing multidetector computed tomography (MDCT) imaging. Methods: An observational cross-sectional study on 100 patients at CT scan Units in El-Mokattam Health Insurance Hospital and Benha University Hospitals. The patients underwent a comprehensive diagnostic work-up including full medical history, clinical examination, blood tests, ECG, and transthoracic echocardiography (TTE) in addition to MDCT for coronary artery calcification (CCS) measurement. Results: Ca 2+ score had a mean value of 466.6 ± 147.9. 38 (38%) patients had Ca 2+ score % < 400 and 62 (62%) patients had Ca 2+ score % > 400. A significant positive correlation was found between Ca 2+ score and age, cholesterol, LDL, and TG (r=0.647, 0.772, 0.717, r=0.651, respectively with P<0.001). There was a significant negative correlation between Ca 2+ score and HDL (r= -0.826, P<0.001). Conclusions: There was a significant association between calcium score and age, lipid profile, as well as HTN, smoking, DM, and ischemic heart disease family history. Furthermore, it was found that patients with a Ca 2+ score > 400 had a higher incidence of hyperlipidemia and were generally older than those with a lower calcium score.

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Section: Discussionmentioning

confidence: 94%

Correlation between Coronary Calcium Score and Lipid Profile

Nammour¹,

Arafa²,

Attia³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…CAC progression is reported to be higher in South Asian men than Chinese, Black, and Latino men, but no difference was observed between South Asian and White men [99,100]. Other reports also show a higher CAC burden in Asian Indians than in other ethnic and racial groups [100,101].…”

Section: Race/ethnicity and Sex In Cacmentioning

confidence: 91%

“…South Asians are reported to have higher atherosclerotic cardiovascular disease event rates compared with other ethnicities [97,98], which correlates with the CAC burden [13]. CAC progression is reported to be higher in South Asian men than Chinese, Black, and Latino men, but no difference was observed between South Asian and White men [99,100]. Other reports also show a higher CAC burden in Asian Indians than in other ethnic and racial groups [100,101].…”

Section: Race/ethnicity and Sex In Cacmentioning

confidence: 95%

Beyond the Basics: Unraveling the Complexity of Coronary Artery Calcification

Hashmi,

Shah,

Aherrahrou

et al. 2023

Cells

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Coronary artery calcification (CAC) is mainly associated with coronary atherosclerosis, which is an indicator of coronary artery disease (CAD). CAC refers to the accumulation of calcium phosphate deposits, classified as micro- or macrocalcifications, that lead to the hardening and narrowing of the coronary arteries. CAC is a strong predictor of future cardiovascular events, such as myocardial infarction and sudden death. Our narrative review focuses on the pathophysiology of CAC, exploring its link to plaque vulnerability, genetic factors, and how race and sex can affect the condition. We also examined the connection between the gut microbiome and CAC, and the impact of genetic variants on the cellular processes involved in vascular calcification and atherogenesis. We aimed to thoroughly analyze the existing literature to improve our understanding of CAC and its potential clinical and therapeutic implications.

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