Level of Vascular Endothelial Growth Factor in Aqueous Humor and Surgical Results of Ahmed Glaucoma Valve Implantation in Patients With Neovascular Glaucoma

Kim, Yong Guk; Hong, Samin; Lee, Christopher Seungkyu; Kang, Suk‐Ju; Seong, Gong Je; Tak, Kyoung; Kim, Chan Yun

doi:10.1097/ijg.0b013e3181895e5c

Cited by 41 publications

(31 citation statements)

References 11 publications

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“…10 In 19 eyes with neovascular glaucoma treated with the Ahmed Glaucoma Valve, Kim et al found aqueous levels of vascular endothelial growth factor (VEGF) levels significantly higher in the failure group compared with the success group, suggesting a role of this factor in influencing surgical success. 11 Despite improvement of IOP after surgery and mean IOP levels over time that were comparable to controls, visual outcomes were worse, with significantly more eyes with neovascular glaucoma than controls losing light perception vision in this study (P = 0.002). This may have been owing to inadequate control of IOP in eyes with neovascular glaucoma compared with controls, progression of underlying disease, or other factors.…”

Section: Discussioncontrasting

confidence: 64%

The Ahmed Glaucoma Valve in Patients With and Without Neovascular Glaucoma

Netland

Ishida

Boyle

2010

Journal of Glaucoma

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Section: Discussioncontrasting

confidence: 64%

The Ahmed Glaucoma Valve in Patients With and Without Neovascular Glaucoma

Netland

Ishida

Boyle

2010

Journal of Glaucoma

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“…In contrast, epibulbar glaucoma drainage implants bypass both the conventional and the uveoscleral route entirely but are subject to encapsidation that is the result of fibrosis and a chronic foreign body reaction [19]. We recently expanded our practice pattern to use AIT as a first surgery for more than mild glaucoma because our studies suggested that AIT can be used after failed trabeculectomy [10], in narrow angles [20] and for more severe glaucoma [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching

Kostanyan

Shazly

Kaplowitz

et al. 2017

Graefes Arch Clin Exp Ophthalmol

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1 AbstractPurpose: To apply propensity score matching to compare Baerveldt glaucoma drainage implants (BGI) to trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggests that AIT can produce results similar to BGI which is traditionally reserved for more severe glaucoma.Methods: BGI and AIT patients with at least one year of follow-up were included. The primary outcome measures were intraocular pressure (IOP), number of glaucoma medications, and a Glaucoma Index (GI) score. GI reflected glaucoma severity based on visual field, the number of preoperative medications, and preoperative IOP. Score matching used a genetic algorithm consisting of age, gender, type of glaucoma, concurrent phacoemulsification, baseline number of medications, and baseline IOP. Patients with neovascular glaucoma, with prior glaucoma surgery or without a close match were excluded.Results: Of 353 patients, 30 AIT patients were matched to 29 BGI patients. Baseline characteristics including, IOP, the number of glaucoma medications, type of glaucoma , the degree of VF loss and GI were not significantly different between AIT and BGI. BGI had a preoperative IOP of 21.6±6.3 mmHg compared to 21.5±7.4 for AIT on 2.8±1.1 medications and 2.5±2.3, respectively. At 30 months, the mean IOP was 15.0±3.9 mmHg for AIT versus 15.0±5.7 mmHg for BGI (p>0.05), while the number of drops was 1.5±1.3 for AIT (change: p=0.001) versus 2.4±1.2 for BGI (change: p=0.17; AIT vs BGI: 0.007). Success, defined as IOP<21 mmHg, <20% reduction and no reoperation, was achieved at 1 year in 56% of AIT versus 55% of BGI (p>0.05) and 50% versus 52% at 2.5 years. Conclusions:A propensity score matched comparison of AIT and BGI demonstrated a similar IOP reduction through one year. AIT required fewer medications.2

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“…Several studies have shown that levels of VEGF, and TGF-β1 and TGF-β 2 increase in the vitreous and aqueous humor in NVG [3,28]. Kim et al [29] stated that among patients who underwent AVG implantation, elevated VEGF levels in aqueous humor were detected in the group of patients whose surgeries failed. This finding shows that preoperative use of anti-VEGF agents can increase surgical success rates in NVG.…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravitreal Bevacizumab Injection before Ahmed Glaucoma Valve Implantation in Neovascular Glaucoma

et al. 2013

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Purpose: To assess the efficacy of preoperative intravitreal bevacizumab injection (IVB) before Ahmed glaucoma valve (AGV) implantation in the treatment of neovascular glaucoma (NVG). Methods: This retrospective, comparative and consecutive case series study included 41 eyes from 41 patients who underwent AGV implantation for treatment of NVG. The study group was composed of 19 patients (19 eyes) to whom IVB was administered before surgery, while the control group was composed of 22 patients (22 eyes) to whom IVB was not administered before AGV implantation. Findings such as intraocular pressures measured before and after surgery, surgical success rates, and postoperative complications were compared between the groups. Results: There were no significant differences in preoperative data between groups. The surgical success rate in the study group (79%) was better than in the control group (64%), but this difference was not statistically significant (p = 0.28). Early postoperative complications such as fibrinous reaction in the anterior chamber as well as hyphema were less frequently observed in the study group. Conclusions: Intravitreal bevacizumab is a useful preparatory step to safely and effectively implant an aqueous shunting tube in eyes with severe NVG and intractable intraocular pressure.

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Level of Vascular Endothelial Growth Factor in Aqueous Humor and Surgical Results of Ahmed Glaucoma Valve Implantation in Patients With Neovascular Glaucoma

Abstract: The level of VEGF in aqueous humor was significantly higher in the failure group after the Ahmed glaucoma implantation compared with the success group. Our results imply that VEGF may play a role in determining surgical success after Ahmed valve implantation in patients with NVG.

Cited by 41 publications

References 11 publications

The Ahmed Glaucoma Valve in Patients With and Without Neovascular Glaucoma

The Ahmed Glaucoma Valve in Patients With and Without Neovascular Glaucoma

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching

Effect of Intravitreal Bevacizumab Injection before Ahmed Glaucoma Valve Implantation in Neovascular Glaucoma

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