Level of serum IL-12 and its correlation with endothelial dysfunction, insulin resistance, proinflammatory cytokines and lipid profile in newly diagnosed type 2 diabetes

Mishra, Manish; Kumar, Hemant; Bajpai, Surabhi; Singh, Rakesh Kumar; Tripathi, Kamlakar

doi:10.1016/j.diabres.2011.07.037

Cited by 70 publications

(58 citation statements)

References 25 publications

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“…An association between IL-12 and in vitro markers of endothelial dysfunction, including nitric oxide, has been reported in a cohort of 100 patients with type 2 diabetes. 5 While IL-18 levels were not measured in this study, the findings are still in keeping with our study, as increased PWV or arterial stiffness is in part a consequence of reduced nitric oxide bioavailability and associated endothelial dysfunction. 17 However, unlike our study, a recent study of 97 males with significant cardiac risk factors demonstrated a strong association between IL-18 and PWV (but not IL-12).…”

Section: Discussionsupporting

confidence: 66%

“…2,3 Elevated serum levels of IL-12 and IL-18 have also been observed in several human disease states including metabolic syndrome, obesity, type 2 diabetes, hypertension, and systemic lupus erythematosus (SLE). [4][5][6][7] Noninvasive measurements of arterial stiffness, including aortic pulse wave velocity (PWV) and augmentation index (AIx), are established surrogate markers of CVD-associated and all-cause mortality in the general population, and may have utility in CVD-risk stratification. 8 IL-18 is independently associated with CVD-related outcomes and also PWV in prospective and cross-sectional studies limited to individuals with CVD risk factors.…”

Section: Doi:101093/ajh/hps032mentioning

confidence: 99%

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Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals

Yong

Dogra

Boudville

et al. 2012

American Journal of Hypertension

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Section: Discussionsupporting

confidence: 66%

Section: Doi:101093/ajh/hps032mentioning

confidence: 99%

Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals

Yong

Dogra

Boudville

et al. 2012

American Journal of Hypertension

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“…Because DM is a chronic inflammatory disease, we examined changes in the levels of inflammatory cytokines selected based on previous studies [18,19]. Interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α were measured using human ELISA kits (R&D Systems, Minneapolis, Minn., USA, and Enzo Life Sciences, Ann Arbor, Mich., USA).…”

Section: Methodsmentioning

confidence: 99%

Beneficial Effects of Fresh and Fermented Kimchi in Prediabetic Individuals

Lee²,

Jeon³

et al. 2013

Ann Nutr Metab

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Background: With the increased incidence of diabetes mellitus, the importance of early intervention in prediabetes has been emphasized. We previously reported that fermented kimchi, a traditional Korean food, reduced body weight and improved metabolic factors in overweight participants. We hypothesized that kimchi and its fermented form would have beneficial effects on glucose metabolism in patients with prediabetes. Methods: A total of 21 participants with prediabetes were enrolled. During the first 8 weeks, they consumed either fresh (1-day-old) or fermented (10-day-old) kimchi. After a 4-week washout period, they switched to the other type of kimchi for the next 8 weeks. Results: Consumption of both types of kimchi significantly decreased body weight, body mass index, and waist circumference. Fermented kimchi decreased insulin resistance, and increased insulin sensitivity, QUICKI and disposition index values (p = 0.004 and 0.028, respectively). Systolic and diastolic blood pressure (BP) decreased significantly in the fermented kimchi group. The percentages of participants who showed improved glucose tolerance were 9.5 and 33.3% in the fresh and fermented kimchi groups, respectively. Conclusions: Consumption of kimchi had beneficial effects on glucose metabolism-related and anthropometric factors in participants with prediabetes. Fermented kimchi had additional effects on BP and insulin resistance/sensitivity. The percentage of participants who showed improvement in glucose tolerance was high in the fermented kimchi group.

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“…Oncogenes and oxidative stress induce vascular endothelial cells to exhibit distinct expression patterns of proinflammatory cytokines (39). In newly diagnosed type 2 diabetes, levels of serum IL-12 correlate with endothelial dysfunction, insulin resistance and the expression of proinflammatory cytokines (40). Exposure to Shiga toxin 1, Shiga toxin 2, and α-sarcin induces molecular damage and upregulates proinflammatory cytokines in human endothelial cells (41).…”

Section: Discussionmentioning

confidence: 99%

Chebulagic acid inhibits the LPS-induced expression of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation

Liu

Bao

Liu

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Inflammatory response in the vasculature, including the overexpression of tumor necrosis factor (TNF)-α and interleukin (IL)-1β, has been demonstrated to increase the risk of thrombosis development. Chebulagic acid (CA) is a key chemical component in the traditional Mongolian anti-thrombotic drug Garidi-13, and has been suggested to exert anti-inflammatory and anti-infective effects. The present study aimed to evaluate the regulatory impact of CA on a number of biological processes, including lipopolysaccharide (LPS)-induced inflammation, LPS-promoted mitogen-activated protein kinase (MAPK) activation and the expression of toll-like receptor (TLR)4 in EA.hy926 human endothelial cells. The results indicated that CA significantly inhibited the LPS-induced upregulation of TNF-α and IL-1β in a dose-and time-dependent manner. Furthermore, LPS-activated MAPK signaling was inhibited by CA treatment in the EA.hy926 cells. However, TLR4, which serves a key function in LPS-induced inflammation as the receptor of LPS, was not regulated by the CA treatment. In summary, the results of the present study indicate that CA inhibits the LPS-induced promotion of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation, which may contribute to the anti-thrombotic effect of Garidi-13.

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Level of serum IL-12 and its correlation with endothelial dysfunction, insulin resistance, proinflammatory cytokines and lipid profile in newly diagnosed type 2 diabetes

Cited by 70 publications

References 25 publications

Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals

Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals

Beneficial Effects of Fresh and Fermented Kimchi in Prediabetic Individuals

Chebulagic acid inhibits the LPS-induced expression of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation

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