Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead

Ergürhan-İlhan, I; Cadir, Bilge; Koyuncu-Arslan, Meltem; Arslan, Çağatay; Gültepe, FM; Özkan, Güleren

doi:10.1111/j.1442-200x.2007.02442.x

Cited by 33 publications

(39 citation statements)

References 32 publications

(61 reference statements)

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“…Decreased α-tocopherol concentrations were also reported in a study by Ergurhan-Ilhan et al (42) who examined apprentices exposed to low doses of lead (PbB = 7.9±5.2 μg/dl). Moreover, Caylak et al (44) showed decreased level of vitamin E in rats that were orally exposed to lead acetate.…”

Section: Discussionmentioning

confidence: 78%

“…It was reported that supplementation with the vitamin may increase glutathione production and lower lipid peroxide concentrations (41). This supplementation may also prevent the lead-induced inhibition of superoxide dismutase (SOD) and catalase (42). Furthermore, α-tocopherol weakly increases ALAD levels in rabbits with chronic plumbism (43).…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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“…Struzynska et al (2002) investigated the effect of lead on glutathione system and observed in cerebellum an increase in total glutathione content comparable to those in other regions of brain. According to Ergurhan-Ilhan et al (2008), the GPx activity was found to increase in erythrocytes of apprentices chronically exposed to lead. Adonaylo and Oteiza (1999) also made a similar observation of increase in GPx activity in whole brain on exposure to lead and they correlated this increase to the protective response of the brain tissue to oxidative stress caused by lead.…”

Section: Discussionmentioning

confidence: 96%

“…Lead causes toxicity not only to the developing brain Bellinger, 2007) but also to the adults on occupational exposure (Gracia and Snodgrass, 2007;Schwartz and Hu, 2007;Ergurhan-Ilhan et al, 2008). According to Patrick (2006a) and Hu and Woolf (2007), lead contamination results in cognitive dysfunction, neurological damage, neurobehavioural disorders, hypertension, renal failure and reproductive defects in adults.…”

Section: Introductionmentioning

confidence: 97%

Influence of lead acetate on glutathione and its related enzymes in different regions of rat brain

Bokara

Blaylock

Denise

et al. 2009

J of Applied Toxicology

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This study is intended to determine the effect of lead acetate on glutathione and its associated enzymes of rat brain. Wistar male rats were treated with lead acetate (500 ppm) through drinking water for a period of 8 weeks and parallel controls were maintained. They were sacrificed at the first, fourth and eighth week to isolate whole brains, which were separated into cerebellum, hippocampus, frontal cortex and brain stem. The data indicate enhanced (P < 0.05) glutathione peroxidase (G-Px) activity at most of the intervals for cerebellum, frontal cortex and brain stem, suggesting conversion of GSH to GSSG, while the hippocampus showed decreased levels. In contrast, glutathione reductase (GR) decreased significantly (P < 0.05) in cerebellum, frontal cortex and brain stem at all intervals except the fourth week in frontal cortex and brain stem. Hippocampus exhibited a gradual and significant (P < 0.05) increase in GR activity. Glutathione-S-transferase (GSTase) activity increased with exposure time in all four brain tissues, showing protection against lead acetate toxicity. The GSH and GSSG levels correlated well with the activities of GPx, GR and GSTase in all four regions of the brain. Overall the results indicate that lead acetate affects glutathione-related enzymes differentially and these changes can be attributed to differences in tissue susceptibility.

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“…Table 4 shows that MDA levels were the most frequently used biomarker for measuring LPO. Twenty studies found MDA levels to be signifi cantly higher in leadexposed groups (BLL, 5.4-317.3 μg/dL) than in the control groups (BLL, 0-12.5 μg/ dL) (Tenchova et al 1997 ;Ye et al 1999 ;Yucebilgiç et al 2003 ;Gurer-Orhan et al 2004 ;Kasperczyk et al 2004aKasperczyk et al , b , 2009Kasperczyk et al , 2013aOktem et al 2004 ;Patil et al 2006a , b ;Garçon et al 2007 ;Ergurhan-Ilhan et al 2008 ;Khan et al 2008 ;Mohammad et al 2008 ;Grover et al 2010 ;Permpongpaiboon et al 2011 ;Singh et al 2013 ). Among these, 15 studies reported a signifi cant positive correlation between BLLs and MDA concentrations ( r = 0.15-0.80; p < 0.05).…”

Section: Lead-induced Oxidative Stress In Occupationally Exposed Popumentioning

confidence: 96%

Lead Exposure and Oxidative Stress: A Systematic Review

Lopes

Peixe

Mesas³

et al. 2016

Reviews of Environmental Contamination and Toxicology

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Lead is an environmental toxicant that can induce oxidative stress (OS) via reactive oxygen species (ROS) generation, which has been reported as an important mechanism underlying lead toxicity (Gurer and Ercal 2000; Pande and Flora 2002; Kasperczyk et al. 2004a; Farmand et al. 2005; Verstraeten et al. 2008; Wang et al. 2009; Martinez-Haro et al. 2011). OS occurs when the generation of ROS exceeds the antioxidant system's ability to defend cells against oxidized molecules. ROS is a term generally used to refer to free radicals derived from O2 (e.g., superoxide anions [O2-] and hydroxyl radicals [OH-]) or to non-radical species (e.g. hydrogen peroxide [H2O2]) (Halliwell and Cross 1994).

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Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead

Abstract: Chronic indirect Pb exposure results in lipid peroxidation in erythrocytes of apprentices via OS, and duration of Pb exposure is a reliable marker of Pb toxicity.

Cited by 33 publications

References 32 publications

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Influence of lead acetate on glutathione and its related enzymes in different regions of rat brain

Lead Exposure and Oxidative Stress: A Systematic Review

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