Leukotrienes

The conformational analysis of leukotriene D4 in aqueous solution based on high-field nuclear magnetic resonance measurements

“…They may therefore be important mediators of human diseases such as bronchial asthma. This research has now been well reviewed (7)(8)(9)(10)(11). The geometrical assignments of the double bonds of the different leukotrienes as well as the stereochemical assignments have been made possible by total syntheses and subsequent comparison of synthetic and natural products (12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Synthesis of a Novel Unsaturated Polyolefin Intermediates, Aldehyde and Fatty Acid

“…1 The importance of polyunsaturated fatty acids in diet and human health is well documented. Fatty acids have several usages which retain them important.…”

Total Synthesis of Leukotrienes from Butadiene

“…The same chiral key intermediate was used in all later reported total syntheses. [20] Cohan and coworkers obtained this key intermediate from -araboascorbic acid, [21] whereas Rokach et al, [22] and Bantik et al, [23] used different approaches from 2-deoxy--ribose for their chiral-pool synthesis. Baker et al used -glucose as the chiral starting material.…”