Leukotriene Signaling in Atherosclerosis and Ischemia

Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China

“…[21] Thus, the potent LTs-induced immunostimulatory actions indicate a key role in the development of atheroma. Besides, some studies [10,11] have indicated a role for the LTs pathway in plaque rupture, causing thrombosis and vessel occlusion. The plaque rupture induces ischemia in distal organs (such as the brain), and the contribution of LTs in stroke has also been studied in models of ischemia and reperfusion.…”

“…Thus, genetic effects in the LTs biosynthesis pathway could be a potential contributor to an increased risk of IS. [10] In order to investigate the contribution of genetic variations in LTs-related genes (i.e. genes encoding key enzymes in this pathway) to IS in a cohort of Chinese in east China, a case-control study was carried out to clarify the involvement of ALOX5, LTA4H and LTC4S single nucleotide polymorphisms (SNPs) as risk factors for the pathogenesis of IS.…”

5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity

“…They are also intimately involved in allergic asthma, atopic dermatitis, allergic rhinitis, arthritis, atherosclerosis and ischemia, tumorigenesis, and septic shock [1][2][3][4][5][6][7]. LTs COX-1 and COX-2 could be accounted for due to compartmentalization within the cell.…”

Clinical Significance of Leukotriene B4 and Extracellular Matrix Metalloproteinase Inducer in Acute Coronary Syndrome

“…Although the mechanisms of unstable plaque rupture are complex and poorly understood, more and more studies have indicated a key role of leukotriene (LTs), products of the 5-lipoxygenase (5-LO) pathway, in the pathogenesis of ACS [1]. Matrix metalloproteinases (MMPs) are a family of zinc-containing enzymes that play an important role in a variety of physiological and pathological processes, including tissue repair, cardiac and vascular remodeling and atherosclerotic plaque instability [2][3][4].…”