Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum

Huang, Shih-Che

doi:10.1016/j.lfs.2011.02.023

Cited by 4 publications

(3 citation statements)

References 35 publications

(74 reference statements)

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“…Prostaglandin D2 can inhibit the development of gastric cancer [40]. Leukotriene D4 can aggravate gastric contraction and promote gastric acid secretion [41,42]. However, gastric pH increases during GPL and gastric cancer [43].…”

Section: Gc-tof-ms and Uhplc-qe-ms Have Different Advan-mentioning

confidence: 99%

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Zhang

Morris

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. In this study, we analyzed the metabolite profile of the tongue coating of patients having gastric precancerous lesion (GPL) with damp phlegm pattern and proposed a mechanism of pathological transition. Methods. The changes in tongue-coating metabolites in patients with GPL damp phlegm pattern were analyzed using GC-TOF-MS and UHPLC-QE-MS metabolomics methods. Results. When compared with 20 patients who did not exhibit a nondamp phlegm pattern, 12 metabolites were highly expressed and 10 metabolites were under expressed in 40 cases of damp phlegm pattern, of which involved 9 metabolic pathways. Compared with 15 healthy people, 134 metabolites were upregulated and 3 metabolites were downregulated in 40 cases exhibiting a damp phlegm pattern, of which involved 17 metabolic pathways. The patients with damp phlegm pattern were compared with nondamp phlegm pattern patients and healthy people, the main differential metabolites were primarily lipids and lipid-like molecules, and the main differential metabolic pathways were related to glycerophospholipid metabolism. In the glycerophospholipid metabolism, the metabolites with changes were phosphatidylethanolamine and lysoPC(18 : 1 (9z)). Among them, phosphatidylethanolamine exists in the synthesis stage of glycerophospholipid metabolism.Conclusions. Abnormal expression of lipids and lipid-like molecules, as the major metabolic change, was involved in the formation of GPL patients with damp phlegm pattern.

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Section: Gc-tof-ms and Uhplc-qe-ms Have Different Advan-mentioning

confidence: 99%

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Zhang

Morris

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Measurements of contraction of the isolated terminal ileal segments were performed according to the procedure described previously with modifications (Huang, 2011). Male Sprague-Dawley rats weighing 350-400 g, were sacrificed with CO 2 .…”

Section: Measurement Of Contraction Of Rat Isolated Ileummentioning

confidence: 99%

Salvia miltiorrhiza causes tonic contraction in rat ileum through Ca2+-calmodulin pathway

Tsai

Huang

Liu

et al. 2012

Journal of Ethnopharmacology

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“…Leukotrienes have been implicated as mediators of acute synovial inflammation, cardiovascular disease, gastrointestinal tract disorders, allergic dermatologic conditions, and certain cancers. [1][2][3] The best characterization of the effects is for those within the respiratory tract, where they mediate airway hyperresponsiveness, mucus production, bronchoconstriction, increases in vascular permeability, and inflammation. 4 The importance of CysLTs in human respiratory medicine is supported by the clinical efficacy of the CysLT 1receptor antagonists, montelukast and zafirlukast, in asthmatic human patients.…”

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confidence: 99%

Effects of leukotriene C4 on the bioelectric properties and ion transport of equine tracheal epithelium

Lester

Rice²

2012

ajvr

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Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum

Cited by 4 publications

References 35 publications

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Salvia miltiorrhiza causes tonic contraction in rat ileum through Ca2+-calmodulin pathway

Effects of leukotriene C4 on the bioelectric properties and ion transport of equine tracheal epithelium

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