Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

Serhan, Charles N.; Radin, Allen; Smolen, James E.; Korchak, Helen M.; Samuelsson, Bengt; Weissmann, Gerald

doi:10.1016/0006-291x(82)90622-2

Cited by 225 publications

(130 citation statements)

References 23 publications

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“…It has also been proposed that in FMF, any minor stimulus leads to an uncontrolled inflammatory reaction with complement activation, due to an absence of an inhibitor of C5a and excessive tumour necrosis factor release (19)(20)(21). The inflammatory process of FMF is also caused by leukotriene B 4 , a potent lipid chemoattractant and mediator of acute inflammation (22,23). This inflammation may act to impair endothelial function, arterial compliance and arterial elasticity, and act as a contributing factor in the initiation or the progression of atherosclerosis (9,10).…”

Section: Discussionmentioning

confidence: 99%

The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever

Yıldız

Masatlýoglu²,

Seymen

et al. 2006

Canadian Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever

Yıldız

Masatlýoglu²,

Seymen

et al. 2006

Canadian Journal of Cardiology

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“…All patients were assessed with clinical and laboratory evaluations on days 0, 7, and 14 of the in-hospital period. Nine patients (patients 1-9) were further evaluated for neutrophil function, and 4 patients (patients [11][12][13][14] were evaluated for leukotriene release. Sera and platelets or granulocytes from patients 6-13 were analyzed for fatty acid composition.…”

Section: Methodsmentioning

confidence: 99%

Effects of fasting on disease activity, neutrophil function, fatty acid composition, and leukotriene biosynthesis in patients with rheumatoid arthritis

Hafström

Ringertz

Gyllenhammar

et al. 1988

Arthritis & Rheumatism

104

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Fourteen patients with rheumatoid arthritis (RA) were studied before, during, and after a 1-week total fast. Disease activity decreased, as did the neutrophil release of lysozyme induced by the ionophore A23187. The ability of zymosan-activated RA patient serum to aggregate control neutrophils was reduced, together with serum concentrations of C3. The relative contents of arachidonic acid and eicosapentaenoic acid were increased in serum, platelets, and neutrophils, whereas levels of linoleic acid and linolenic acid were unchanged. Fasting also reduced the release of leukotriene B, from neutrophils. We thus conclude that a reduced ability to generate cytotaxins, reduced release of enzyme, and reduced leukotriene formation from RA neutrophils, together with an altered fatty acid composition of membrane phospholipids, may be mechanisms for the decrease of inflammatory symptoms that results from fasting.From the Rheumatology and Hematology Sections, Department of Medicine 111,

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“…It seems highly likely that the ability of LTs to enhance phagocytosis reflects the fact that the requisite signal transduction events downstream from opsonin or microbial recognition receptors are themselves amplified by ligation of the LT receptors. An alternative paradigm is exemplified by the fact that LTB 4 (52). LTB 4 also induced the release of the antimicrobial peptide ␣-defensin by human neutrophils (53).…”

Section: Antimicrobial Effector Functions Of Ltsmentioning

confidence: 99%

Leukotrienes: Underappreciated Mediators of Innate Immune Responses

Peters‐Golden¹,

Canetti²,

Mancuso

et al. 2005

The Journal of Immunology

278

244

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Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is less well appreciated. These molecules are indeed synthesized by resident and recruited leukocytes during infection. Acting via cell surface G protein-coupled receptors and subsequent intracellular signaling events, they enhance leukocyte accumulation, phagocyte capacity for microbial ingestion and killing, and generation of other proinflammatory mediators. Interestingly, a variety of acquired states of immunodeficiency, such as HIV infection and malnutrition, are characterized by a relative deficiency of leukotriene synthesis. The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity.

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Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysis

Cited by 225 publications

References 23 publications

The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever

The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever

Effects of fasting on disease activity, neutrophil function, fatty acid composition, and leukotriene biosynthesis in patients with rheumatoid arthritis

Leukotrienes: Underappreciated Mediators of Innate Immune Responses

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