Leukotriene B<sub>4</sub> production by blood neutrophils in allergic rhinitis—effects of cetirizine

Cheria-Sammari, S.; Aloui, R.; Gormand, F.; Chabannes, B.; Gallet, H.; Grosclaude, M.; Mélac, M.; Rihoux, J P; Perrin‐Fayolle, M; Lagarde, Michel; Pachéco, Yves

doi:10.1111/j.1365-2222.1995.tb00010.x

Cited by 31 publications

(10 citation statements)

References 40 publications

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“…These in vitro data were confirmed in several in vivo conditions in atopic subjects. It was shown for instance that the drug inhibited the release of LTC 4 and LTB 4 from leukocytes of patients treated with the drug [20, 21]. Moreover Naclerio [22]showed that oral administration of CTZ significantly inhibits the appearance of LTC 4 in the nasal lavage fluid after antigen provocation in atopics, and finally Michel et al [23]showed that the drug inhibits the rise in histamine skin of atopics during an antigen–induced late–phase reaction (skin chamber technique).…”

Section: The Inhibition Of Mediator Releasementioning

confidence: 99%

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Rihoux

Michel²,

Arnold³

et al. 1999

Int Arch Allergy Immunol

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Some recent clinical studies carried out with the potent H₁–antihistamine cetirizine (CTZ) suggest that this drug could be useful for the treatment of mild to moderate asthma and even for the prevention of the disease. Besides a potent antagonism of H₁–receptors at bronchial level, this drug was also shown to exert a large series of anti–inflammatory effects in in vitro, ex vivo and in vivo pharmacological models and also in clinical situations in atopic subjects. All the data collected up to now suggest the possible existence in the molecule of a central key mechanism of action on resident cells especially involved in cell trafficking and bronchial inflammation, i.e a down–regulating effect on the nuclear factor_KB (NF_KB). This hypothesis was tested on human endothelial cells and a human epithelial pulmonary cell line using different experimental methods. The results showed that CTZ down–regulates the TNF–α–induced hyperactivation of NF_KB in these two different resident cells at physiological concentrations.

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Section: The Inhibition Of Mediator Releasementioning

confidence: 99%

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Rihoux

Michel²,

Arnold³

et al. 1999

Int Arch Allergy Immunol

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“…Antiinflammatory activity of cetirizine has been documented in a variety of in vitro as well as in vivo animal and human studies. It inhibits eosinophil accumulation at skin, conjunctiva, reduces LTB 4 , and LTC 4 production from blood leucocytes [75][76][77]. Cetirizine has been shown to be able to reduce nasal inflammatory infiltration and cytokine production in children with PAR [78].…”

Section: Cetirizinementioning

confidence: 97%

New Oral Antihistamines in Pediatrics and Safety of Antihistamines in Children

Öneş¹,

Tamay

2005

CMCAIAA

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H1 antihistamines are first line drugs in the treatment of allergic rhinitis and chronic idiopathic urticaria and widely used in children as well as in adults. Although first-generation antihistamines are effective in relieving allergic symptoms, they are not preferred because of their sedative side effects. The earliest "second generation" antihistamines, terfenadine and astemizole, non-sedating alternatives to the first generation counterparts are not commonly used due to their potential arythmogenic effects. The newer second-generation antihistamines such as loratadine, fexofenadine, mizolastine, ebastine, cetirizine, levocetirizine and desloratadine have been shown to be efficacious and well tolerated with additional anti-inflammatory effects and lacking cardiotoxic potential activity in adults. The early treatment of atopic children study, the long term clinical trial with cetirizine of infants with atopic dermatitis demonstrated that cetirizine delayed the onset of asthma in patients sensitized to grass pollen or house dust mite; and also reduced the duration and the amount of topical steroids used in the treatment of atopic dermatitis. In the Preventia I study, which was designed to evaluate the efficacy of loratadine in reducing the number of respiratory infections in young children at risk of recurrent infections, loratadine was not found to be significantly different from placebo. Both drugs were found to have a similar safety profile to that of placebo confirming their long-term use in infants and children. Pediatric formulation of desloratadine, which has favorable effect on nasal congestion, is marketed worldwide now. The effectiveness of new antihistamines in the treatment of urticaria in pediatric age group is based on extrapolation of adult studies performed in this area. Further studies with new antihistamines are needed for their evidence-based use in children with urticaria and atopic dermatitis.

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“…CET could act on inflammatory cell recruitment by inhibiting LTB 4 production by PMNL [335]. The administration of CET does not alter human PMNL chemotaxis and O 2 .-production [189].…”

Section: Ah and Pmnls In Clinical Practicementioning

confidence: 99%

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Nosáľ¹

2006

CHAMC

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In vitro and ex vivo interactions of betaadrenoceptor blocking drugs, antihistamines and chloroquine with blood platelets and polymorphonuclear leukocytes resulted in different alterations of regulatory functions of these blood cells. Inhibition of platelet aggregation, arachidonate regulatory pathway, 5-hydroxytryptamine transportation, removal of platelet membrane receptors, inhibition of second messenger pathways at subcellular level and suppression of phagocytosis are indicative of nonreceptor rather than specific receptor interactions. Binding of drugs with biomembranes is reversible depending on the ionic charge of the molecule and hydrophobicity of the bilayer, partition coefficient, pH and pKa of the amphiphilic molecules and other physico-chemical properties of amphiphilic drugs. Alterations in the drug molecule structure alters the drug-phospholipid binding profile. Any change in the metabolism of membrane phospholipids directly or indirectly influences one or more of the important components of the phospholipid-signalling pathway. In addition to changes in phospholipase A, C and D activities, protein kinase C, calmodulin-phosphodiesterase, Ca2+,Mg2+-ATPase, Na+,K+-ATPase and other messengers were found to be changed in cells and tissue after cationic amphiphilic drug (CAD) administration. Although not much has been understood of the mechanism by which some CAD affect immune functions, there are good reasons to suggest that these effects might occur. CADs share sufficient similarities in their structure even though they come from diverse pharmacological classes. CADs affect ion transport, immune functions, tumour growth, serotonin metabolism and several other functions in the body. Extensive therapeutic use and associated side effects have generated a great deal of interest in understanding the nonreceptor interactions with CADs.

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Leukotriene B₄ production by blood neutrophils in allergic rhinitis—effects of cetirizine

Abstract: As LTB4 is an important chemotactic factor, Cetirizine could act on inflammatory cell recruitment by inhibiting LTB4 production by neutrophils.

Cited by 31 publications

References 40 publications

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

New Oral Antihistamines in Pediatrics and Safety of Antihistamines in Children

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

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Leukotriene B4 production by blood neutrophils in allergic rhinitis—effects of cetirizine

Abstract: As LTB4 is an important chemotactic factor, Cetirizine could act on inflammatory cell recruitment by inhibiting LTB4 production by neutrophils.

Cited by 31 publications

References 40 publications

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

New Oral Antihistamines in Pediatrics and Safety of Antihistamines in Children

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Contact Info

Product

Resources

About

Leukotriene B₄ production by blood neutrophils in allergic rhinitis—effects of cetirizine