Leukopenia in Negro Workmen

Forbes, W H; Johnson, Raymond E.; Consolazio, F

doi:10.1097/00000441-194103000-00013

Cited by 46 publications

(20 citation statements)

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“…Although an ethnic difference in neutrophil counts was ®rst noted more than 50 years ago (Forbes et al 1941), very little is known of the underlying mechanism. It has been suggested that ethnic neutropenia is consequent on a higher proportion of blood neutrophils being in the marginated granulocyte pool.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the effect of marathon running on leucocyte counts of subjects of different ethnic origins: relevance to the aetiology of ethnic neutropenia

et al. 2000

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Summary. Healthy subjects of African ancestry, including Afro-Caribbeans, have been observed to have lower total white cell counts and neutrophil counts than healthy Caucasian subjects. The cause of this ethnic neutropenia is unclear. We have previously found no evidence that increased margination of neutrophils is responsible. In this study, we have investigated mobilization of neutrophils from the bone marrow granulocyte reserve by endurance exercise. We investigated subjects of different ethnic origins before and after they had competed in a marathon race. Before the race, the neutrophil counts of Africans/Afro-Caribbeans were signi®cantly lower than those of Caucasians (means 2´49 and 3´21´10 9 /l respectively; P 0´043). After the race, the difference was greater, as was the degree of signi®cance (means 10´21 and 12´33 respectively; P 0´017). The percentage increment was almost identical whereas the absolute increment was considerably less, although of marginal statistical signi®cance (increment 7´72 and 9´12´10 9 /l respectively; P 0´10). Similar changes were observed in the monocyte count. Before the race, the difference in the means was of marginal statistical signi®-cance (0´35 and 0´41´10 9 /l respectively; P 0´105), whereas after the race the difference was greater and was highly signi®cant (means 0´75 and 1´05´10 9 /l respectively; P 0´001). These observations support the results of our earlier study, both of which suggested that ethnic neutropenia is likely to result from a diminished bone marrow reserve rather than being consequent on altered distribution of neutrophils within the blood stream.

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Section: Discussionmentioning

confidence: 99%

Investigation of the effect of marathon running on leucocyte counts of subjects of different ethnic origins: relevance to the aetiology of ethnic neutropenia

et al. 2000

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“…BFLN is an asymptomatic condition reported in several ethnic groups [1][2][3][4][5][6][7][8][9][10][11]. Mintz and Sachs [ 10] showed that the abso lute leukopenia-neutropenia in the Ye- [6], namely that there is no increased pooling of neutrophils in the granulocyte marginal pool [6].…”

Section: Discussionmentioning

confidence: 99%

“…Benign familial leukopenia-neutrope nia (BFLN) has been reported among Blacks [1][2][3][4][5], West Indians [2] and Yemen ite Jews [6][7][8][9][10][11], It is inherited as an auto somal-dominant trait [4,8]. Various stud ies done to evaluate the mechanism of BFLN [3,6,7,10] revealed only a lowered bone-marrow response to corticosteroids [3,7], Therefore, it has been proposed [3,7] that the defect in this clinical entity might be in polymorphonuclear (PMN) release from the bone marrow storage pool to the peripheral blood.…”

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Pregnancy-Induced Leukocytosis in Yemenite Jews

Shoenfeld¹,

D²,

Neri

et al. 1983

Acta Haematol

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Benign neutropenia is often found among healthy Yemenite Jews. An assessment was made of the magnitude of labor-induced leukocytosis in 44 Yemenite Jewish women, by comparing their hematological values during labor with those of 27 non-Yemenite women. A statistically significant difference was found in the absolute counts of the white blood cells (WBC) during delivery between the two groups, the values being lower among Yemenite Jews [10,291 ± 422] vs. [11,759 ± 630] × 10⁹/1) and similar findings were detected among their infants. The low WBC counts in the Yemenite group at parturition were also associated with significantly lower plasma cortisol levels (Yemenite group: 33.7 ± 3.5 μg/dl; controls: 49.3 × 2.9 μg/dl). A correlation was found between serum cortisol levels and the magnitude of leukocytosis in both groups of women and their infants. These results suggest that a low basal corticosteroid output may contribute to the low white blood cell counts detected in some ethnic groups like the Yemenite Jews.

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“…Prevalence estimates range from 10% to more than 30%. Asymptomatic leukopenia in African-American workmen was described in 1941 (9) and has subsequently been described in larger cohorts of persons in the United States (10 -13). Extensive evaluations of these "neutropenic" persons showed low neutrophil counts with normal subpopulations of lymphocytes and other leukocytes, normal bone marrow morphologic features and cellularity, and no increased risk for local or systemic infections (14 -17).…”

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confidence: 99%