Leukokinins; their pharmacological properties and role in the pathology of fluid (ascites) accumulation

Greenbaum, Lowell M.; Semente, Gloria; Prakash, Ajai; Roffman, Steven

doi:10.1007/bf01972406

Cited by 5 publications

(1 citation statement)

References 15 publications

(12 reference statements)

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“…Greenbaum and co-workers assumed that tumor ascites fluid accumulation reflected the presence of kinin-like substances that increased local vessel permeability (77,78). He found no such substances in native tumor ascites fluids, but kinin-like activity did appear when tumor ascites was incubated in vitro at pH 3.8.…”

Section: Leukokininsmentioning

confidence: 99%

Fibrin as a component of the tumor stroma: origins and biological significance

1983

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An association between cancer and the coagulation system was suggested by Trousseau more than a century ago and initial reports of fibrin deposition in the stroma of solid tumors date back some 25 years. However, the validity and generality of these observations have only quite recently been established, and their implications for an understanding of tumor biology, metastasis, and therapy are only now coming to be appreciated by investigators in the mainstream of cancer research. This article reviews the current status of fibrin's role in the biology of tumor growth, considering in turn: (1) the evidence that fibrin is present in tumors, the nature of such fibrin, and its relation to plasma fibronectin; (2) the mechanisms by which fibrin may come to be deposited in tumors; and (3) the potential biological and medical significance of tumorassociated fibrin deposition and degradation. Among the last are such important possibilities as a barrier function to the immune response and possible roles in angiogenesis, desmoplasia, and metastasis.

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Section: Leukokininsmentioning

confidence: 99%

Fibrin as a component of the tumor stroma: origins and biological significance

1983

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Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

Dvorak

Nagy

Feng

et al. 1999

Current Topics in Microbiology and Immunology

1,807

2,045

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Leukokinin-H generated from human ascites fluid; its isolation and pharmacology

1979

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Leukokinin-H, a pharmacologically active peptide, has been isolated from human ascites fluid following its generation in vitro at acid pH. The peptide has a molecular weight of approximately 2500. The partial sequence of Leu-AlaTyr-Thr-was obtained from the amino-terminal end. Arginine is the terminal amino acid at the carboxyl end.It was demonstrated that while cell-free ascites fluid generates leukokinin-H, the presence of neoplastic cells enhances the formation about 5 fold. A bradykinin-llke peptide was formed in the fluid following storage at a low temperature of 4~The presence of neoplastic cells, however, did not enhance this peptide formation.Procedures are described for the isolation of leukokinln-H by chromatography. The peptide was clearly differentiated from bradykinin, Lys-bradykinin and MetLys-bradyklnin by treatment of the leukoklnin and other kinins with fluorescamine and separation of the fluorescamlne peptides bygel electrophoresls. The pharmacology of leukokiuln-H isolated" from human ascites fluid is described and compared with bradykinin and leukoklnlns PMN and M. Like the other kinins, it is a potent agent in causing vascular permeability. Likewise it is a vasodepressor substance. Unlike bradykinin it has little spasmogenlc activity on the guinea pig ileum. Its pharmacological properties as well as other evidence cited indicates that it may play an important role as a permeability factor in ascites fluid accumulation of neoplastic etiology.

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Leukokinins; their pharmacological properties and role in the pathology of fluid (ascites) accumulation

Cited by 5 publications

References 15 publications

Fibrin as a component of the tumor stroma: origins and biological significance

Fibrin as a component of the tumor stroma: origins and biological significance

Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

Leukokinin-H generated from human ascites fluid; its isolation and pharmacology

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