Leukogram Profile and Clinical Status in<i>vivax</i>and<i>falciparum</i>Malaria Patients from Colombia

Tobón-Castaño, Alberto; Mesa-Echeverry, Esteban; Miranda-Arboleda, Andrés F.

doi:10.1155/2015/796182

Cited by 19 publications

(12 citation statements)

References 41 publications

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“…This study showed a decreased level of haemoglobin (HB) in ART-naïve patients compared to patients on ART and the seronegative controls. The levels of HB decreased with low CD4+ counts in the HIV-infected individuals and supports previous reports which suggest that anaemia in HIV-infected patients is associated with poor disease outcomes [32–34]. The normal haematological indices observed in patients on ART as compared to the seronegative controls shows a response to treatment and a reduction in oxidative stress-induced red blood cells damage [35,36].…”

Section: Discussionsupporting

confidence: 84%

“…The low hematological indices together with the observed low Fe 2+ levels suggest a microcytic anaemia in the ART-naïve HIV-infected patients and support previous studies that have reported low HB, MCV and MCH in HIV treatment-naïve patients compared to patients on ART [32, 33]. The increased levels of WBC, neutrophils and lymphocytes have been implicated in infection-associated complications [34], and consistent with elevated immune response due to high viral load in the ART-naïve patients. The levels of HB, MCV and MCH decreased with low CD4 + counts in the HIV-infected individuals and supports previous reports which suggest that anaemia in HIV-infected patients is associated with poor disease outcomes [35,36].…”

Section: Discussionsupporting

confidence: 82%

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Imbalance of antioxidant enzymes activities and trace elements levels in Ghanaian HIV-infected patients

et al. 2019

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Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) have been associated with high oxidative stress in HIV patients. The disparity in antioxidant-oxidant levels in HIV patients favours viral replication and disease progression. This study aimed at determining the effect of ART on antioxidant enzymes activities and trace elements levels in Ghanaian HIV patients. A total of 242 participants; comprising of 105 HIV-infected patients on ART, 77 HIV-infected ART-naïve, and 60 HIV seronegative controls were recruited for the study. Whole blood was collected and used for haematological profiling, and the determination of CD4 + counts, superoxide dismutase (SOD) activity and trace element levels. Serum was used for liver function tests and the determination of glutathione reductase (GR) activity, and plasma was used to estimate reduced glutathione (GSH) levels. Low levels of haemoglobin (HB), hematocrit, mean cell volume (MCV) and mean cell hemoglobin (MCH), and trace elements were found in ART-naïve patients compared to those on ART and the seronegative controls. In the ART-naïve patients, glutathione reductase (GR) activity and reduced glutathione (GSH) level were significantly low compared to patients on ART and seronegative controls. Activity of SOD was significantly reduced in ART-naïve patients compared to those on ART and the control group, and manganese is the only trace element that showed a strong negative correlation with SOD activity and a positive and significant correlation with CD4 + count, and therefore needs to be investigated further. The study suggests that assessing antioxidant levels or enzymes activities of patients infected with HIV should be considered during therapy.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 82%

Imbalance of antioxidant enzymes activities and trace elements levels in Ghanaian HIV-infected patients

et al. 2019

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“…However, both malaria and dengue patients exhibited significant leucopenia and thrombocytopenia in the acute phase of the infection (Table ) as has been reported earlier . Unlike what was observed for first‐time malaria sufferers in Brazil, there was no change in the number of monocytes in our malaria cohort (Table ) neither did we observe lymphopenia in our cohort as reported . All these changes were transient and reverted to baseline at day 30 (Table ).…”

Section: Resultscontrasting

confidence: 55%

“…22 Unlike what was observed for first-time malaria sufferers in Brazil, 23 there was no change in the number of monocytes in our malaria cohort (Table 1) neither did we observe lymphopenia in our cohort as reported. 24 All these changes were transient and reverted to baseline at day 30 (Table 1).…”

Section: Study Participants and Clinical Parametersmentioning

confidence: 97%

Vivax infection alters peripheral B‐cell profile and induces persistent serum IgM

Patgaonkar

Herbert

Powale

et al. 2018

Parasite Immunology

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B cell-mediated humoral responses are essential for controlling malarial infection. Studies have addressed the effects of Plasmodium falciparum infection on peripheral B-cell subsets but not much is known for P. vivax infection. Furthermore, majority of the studies investigate changes during acute infection, but not after parasite clearance. In this prospective study, we analysed peripheral B-cell profiles and antibody responses during acute P. vivax infection and upon recovery (30 days post-treatment) in a low-transmission area in India. Dengue patients were included as febrile-condition controls. Both dengue and malaria patients showed a transient increase in atypical memory B cells during acute infection. However, transient B cell-activating factor (BAFF)-independent increase in the percentage of total and activated immature B cells was observed in malaria patients. Naïve B cells from malaria patients also showed increased TLR4 expression. Total IgM levels remained unchanged during acute infection but increased significantly at recovery. Serum antibody profiling showed a parasite-specific IgM response that persisted at recovery. A persistent IgM autoantibody response was also observed in malaria but not dengue patients. Our data suggest that in hypoendemic regions acute P. vivax infection skews peripheral B-cell subsets and results in a persistent parasite-specific and autoreactive IgM response.

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“…In the study by Alberto Tobin et al, the prevalence of falciparum is 62.6% and whereas vivax was just 35.2% and mixed infection was 2.1%. 19 In another study by Milind Y Nadkar et al, incidence of vivax malaria was 68.53% and falciparum malaria was 31.47%, and 0% incidence of mixed infections was observed. 20 In another study by Arevalo et al incidence of vivax and falciparum malaria was almost equal, 50.7% by falciparum and 48.9% by vivax malaria and only 0.4% by mixed species.…”

Section: Discussionmentioning

confidence: 93%

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

et al. 2020

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Background: Malaria is a major health problem in many parts of India and some parts of Andhra Pradesh is one of the endemic areas for malaria. The objective was to study clinical profile and outcome of malaria in both species and mixed infection.Methods: Present study was carried out on 100 patients admitted during the period of November 2016 - October 2018 in Narayana medical college and hospital, Nellore. Malaria confirmed by Peripheral thick and thin smear or Antigen Assay underwent detailed clinical history and physical examination. This was followed by monitoring the outcome of the patients with respect to morbidity and mortality.Results: Out Of the 100 patients 58 patients were from rural background, males were predominant, most common age group was 20-30 (34%) followed by 31-40 (31%). Out of 100 patients, 54 patients were falciparum,44 patients had vivax and two had mixed infection. All of the patients had fever followed by chills and rigors (75%), nausea and vomiting (59%), easy fatiguability (28%), pain abdomen (17), cough (14%) in both infections, altered sensorium was seen in only falciparum (20.3%). On clinical examination,70% of the patients had pallor, splenomegaly in 46%, icterus (23%), hepatomegaly (14%) and pedal edema in12 patients were observed. All 0f the patients were treated with appropriate antimalarial drugs for appropriate duration, and all were recovered without any mortality.Conclusions:Malaria is very common disease in our country especially in South India, which is one of the endemic areas. Severe malaria usually caused by the falciparum more than vivax, early diagnosis and treatment decreases the mortality and morbidity.

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Leukogram Profile and Clinical Status invivaxandfalciparumMalaria Patients from Colombia

Cited by 19 publications

References 41 publications

Imbalance of antioxidant enzymes activities and trace elements levels in Ghanaian HIV-infected patients

Imbalance of antioxidant enzymes activities and trace elements levels in Ghanaian HIV-infected patients

Vivax infection alters peripheral B‐cell profile and induces persistent serum IgM

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

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