Leukoerythroblastosis and plasmacytoid lymphocytes in a child with SARS-CoV-2–associated multisystem inflammatory syndrome

Lee, Won Sok; Margolskee, Elizabeth

doi:10.1182/blood.2020007132

Cited by 9 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent study by Mitra et al on LER in patients with COVID-19 disease [4] supports our present study that LER can occur in COVID-19-positive patients. A similar study by Lee and Margolskee [9] showed leukoerythroblastosis and plasmacytoid picture in a seven-year-old child with multisystem inflammatory syndrome (MIS-C). Similarly, a study on multisystem inflammatory syndrome in adults (MIS-A) in SARS-CoV-2 infection was done by Morris et al [10].…”

Section: Discussionsupporting

confidence: 51%

Is a leukoerythroblastic blood picture common in COVID-19-positive adults?

et al. 2021

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 51%

Is a leukoerythroblastic blood picture common in COVID-19-positive adults?

et al. 2021

View full text Add to dashboard Cite

“…9 In one series with 90 patients undergoing bone marrow procedures, 16 patients presented with metastatic non-hematologic malignancies and leucoerythroblastosis was seen in 43.75% of the latter. 12 In this study, maximum number of cases was seen in 21-30 years age group with male to female ratio of 1.1:1. Shubha HV et al 13 and Waghmare T et al 14 also observed maximum cases in 3 r d decade in their study with no significant sex distribution.…”

Section: Discussionmentioning

confidence: 51%

“…9 Recently, Leucoerythroblastosis has also been associated with SARS-CoV-2 infection. 11,12 Common mechanism exists in all the conditions leading to Leucoerythroblastosis: presence of stress or damage to the marrow and the evolution of areas of extramedullary hematopoiesis, where a well organised sinusoidal structure may not exist and the physiologic and physical barriers restraining immature cells may not be effective as in the marrow. 8 Though little is known about the premature release of immature cells in pathologic states, it has been reported that leucoerythroblastosis is more common when fibrosis accompanies tumour in the bone marrow.…”

Section: Discussionmentioning

confidence: 99%

Role of bone marrow aspiration and biopsy in evaluation of leucoerythroblastic blood picture

Sharma

Hans²,

Naz³

2022

PJMS

View full text Add to dashboard Cite

Leucoerythroblastosis was considered as a circulating expression of haematological and non-haematological malignancies. However many benign conditions are also associated with leucoerythroblastosis such as hemolytic anaemia, marked infections and congestive cardiac failure, etc. So the study was performed to determine the various causes of leucoerythroblastic blood picture on bone marrow examination. The current retrospective diagnostic analytical study was performed in the hematology section of post graduate department of pathology over a period of one year. 80 patients with leucoerythroblastic picture on peripheral blood film (PBF), who were subjected to bone marrow aspiration and/or biopsy were included in the study. The findings were documented on a predefined performa and results tabulated.Majority of cases were seen in 21-30 years age group (25%) with male to female ratio of 1.1:1. Non-neoplastic disorders accounted for majority of cases (65%) while neoplastic lesions were seen in 35% cases. Megaloblastic anaemia was the commonest neo-neoplastic etiology while acute leukemia was the commonest neoplastic disorder in the present study.Leucoerythroblastosis represents disordered marrow function and is reflected in PBF. Bone marrow aspiration and biopsy help in establishing early diagnosis and management of the underlying condition.

show abstract

“…This case was diagnosed with transient leukoerythroblastosis in the setting of an acute SARS-CoV-2 infection. It has been shown by a few groups, including ours, that immature erythroid and myeloid precursors are seen in peripheral smear of patients with SARS-CoV-2 infection [ 23 , 24 ]. Based on a current literature search, we believe that our case is the first study to report leukoerythroblastosis in a pregnant SCD patient with SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 98%

Leukoerythroblastosis in a Sickle Cell Patient With Pregnancy: An Interesting Peripheral Blood Smear Finding

Mitra¹,

Mitra²,

Patel³

et al. 2022

J Hematol

View full text Add to dashboard Cite

The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shaken the entire world. The social, health and financial impacts of this pandemic are beyond words. We have learnt a lot about this new disease in a short period of time, but still a long road to go to fully determine its pathogenic effect. The primary target of this virus is angiotensin-converting enzyme 2 (ACE2) receptor, which is prevalent in endothelial cells throughout the body. Immunocompromised patients such as patients with sickle cell disease are more vulnerable to severe respiratory infections, including infection with SARS-CoV-2. In addition, sickle cell disease patients are prone to vaso-occlusive crisis, and theoretically SARS-CoV-2 can worsen the situation as it also can cause endothelial dysfunction and thrombosis. Herein, we are sharing an interesting peripheral blood smear finding of an asymptomatic 31-year-old multigravida pregnant female with a history of sickle cell disease and found to have a positive COVID-19 polymerase chain reaction (PCR) test during her third trimester of pregnancy at a routine clinic visit. Two weeks after the initial positive test, she developed nausea, vomiting, constipation and a pain crisis affecting her extremities while her COVID-19 PCR test was still positive. She was hemodynamically stable, and lab workup revealed chronic anemia, leukocytosis with neutrophilia and lymphopenia. Morphologic examination of the peripheral blood smear showed a marked leukoerythroblastosis: rare myeloblasts, sickle cells, markedly abundant nucleated red blood cells (RBCs), metamyelocytes, and many large and giant platelets were seen. In this context, her previous peripheral blood smears (prior to positive COVID-19 test) did not show leukoerythroblastosis. She was managed conservatively with hydration and pain control and delivered at 36 weeks via cesarean section due to pre-term labor and intrauterine growth retardation. The unusual finding of leukoerythroblastosis in a pregnant sickle cell disease patient with an asymptomatic COVID-19 infection indicates further studies to determine its effect on hematopoietic system and elucidate its clinical significance.

show abstract

Leukoerythroblastosis and plasmacytoid lymphocytes in a child with SARS-CoV-2–associated multisystem inflammatory syndrome

Cited by 9 publications

References 0 publications

Is a leukoerythroblastic blood picture common in COVID-19-positive adults?

Is a leukoerythroblastic blood picture common in COVID-19-positive adults?

Role of bone marrow aspiration and biopsy in evaluation of leucoerythroblastic blood picture

Leukoerythroblastosis in a Sickle Cell Patient With Pregnancy: An Interesting Peripheral Blood Smear Finding

Contact Info

Product

Resources

About