Leukocytosis as an initial sign of aggressive growth of granulocyte colony-stimulating factor-producing cervical cancer

Yabuta, Matahiro; Takeuchi, Kyousuke; Kitazawa, Sohei; Morita, Hiroki

doi:10.1016/j.ijgo.2010.06.015

Cited by 8 publications

(7 citation statements)

References 3 publications

(5 reference statements)

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“…In gynecologic malignancies, there have been a total of 18 cases reported of leukocytosis and elevated GCSF in addition to the 4 women in the above-mentioned review. Overall, fourteen women had cervical cancer ( Ahn et al, 2005 , Connor, 2006 , Granger and Kontoyiannis, 2009 , Kyo et al, 2000 , Mabuchi et al, 2010 , Matsumoto et al, 2010 , Nasu et al, 2004 , Watanabe et al, 2000 , Yabuta et al, 2010 ), five had uterine cancer ( Granger and Kontoyiannis, 2009 , Hada et al, 2004 , Nakayama et al, 2012 , Yamamoto et al, 2013 ), and three had peritoneal/ovarian cancer ( Granger and Kontoyiannis, 2009 , Mikami et al, 2005 , Sudo et al, 1996 ). These cases are summarized in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Tumor production of GCSF in gynecologic malignancy is rare ( Ahn et al, 2005 , Connor, 2006 , Granger and Kontoyiannis, 2009 , Hada et al, 2004 , Kyo et al, 2000 , Mabuchi et al, 2010 , Matsumoto et al, 2010 , Mikami et al, 2005 , Nakayama et al, 2012 , Nasu et al, 2004 , Sudo et al, 1996 , Watanabe et al, 2000 , Yabuta et al, 2010 , Yamamoto et al, 2013 ). In this case report, we describe a patient with endometrial cancer who developed unexplained leukocytosis during treatment of recurrent disease.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Leukocytosis due to markedly elevated granulocyte-colony stimulating factor levels in a patient with endometrial cancer: Case report and literature review

Clark¹,

Moll²,

Houghton³

et al. 2017

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leukocytosis due to markedly elevated granulocyte-colony stimulating factor levels in a patient with endometrial cancer: Case report and literature review

Clark¹,

Moll²,

Houghton³

et al. 2017

Gynecologic Oncology Reports

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“…In Japan the first case of a G-CSF-producing tumor in the lung was reported by Asano et al in 1977 [4]. In terms of site of onset, G-CSF-producing tumors are most often reported in patients with lung cancer [4,5], with other described cases including cancer of the stomach [6], pancreas [7], skin [8], kidneys [9], and uterine cervix [10,11]. However, there are relatively few studies on G-CSF-producing tumors occurring in the head and neck, including the upper jaw, gums, thyroid, tongue, and parotid glands [12-14].…”

Section: Discussionmentioning

confidence: 99%

Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the lower gingiva: a case report

et al. 2012

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The present study summarizes our experience in treating a patient with a suspected granulocyte colony-stimulating factor (G-CSF)-producing squamous cell carcinoma (SCC) of the lower gingiva, which is a rather rare entity. A 56-year-old woman underwent surgical excision of palate leukoplakia in 1996. In 2009, however, a leukoplakic superficial tumor was detected in the lower left gingiva, for which the patient underwent gingivectomy. This was subsequently diagnosed as SCC. The patient also underwent superselective arterial injection chemotherapy combined with radiotherapy, after local recurrence was observed. The patient was subsequently found to have bone metastasis. After chemotherapy combined with radiotherapy, the patient underwent segmental resection of the lower left jaw, left supraomohyoid neck dissection, and lower jaw reconstruction using titanium plates. Resection of the left femoral tumor and left total knee replacement were also performed. Computed tomography scan performed 1 month after the surgeries revealed multiple lung, liver, spine, and subcutaneous metastases. The patient also exhibited a sudden increase in her white blood cell (WBC) count and a fever that could not be alleviated, despite treatment with antibacterial drugs. A G-CSF-producing tumor was therefore suspected. Serum G-CSF level was high at 250 pg/ml. The patient's WBC count increased to 32 × 10 3 /ml and her general condition suddenly deteriorated, and she died as a result of multiple organ failure. A final diagnosis of G-CSF-producing SCC of the lower gingiva was made based on the patient's clinical course.

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“…Leukocytosis has been reported to be an initial sign of aggressive tumor extension. Furthermore, the histological changes that accompany poor differentiation associated with leukocytosis might influence the subsequent virulent clinical features [15]. Among bone and soft-tissue tumors, G-CSF-secreting tumors have been reported to be associated with undifferentiated tumors [8,16].…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF

et al. 2011

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Leukocytosis associated with secretion of granulocyte colony-stimulating factor (G-CSF) has been reported in various tumors, primarily poorly differentiated epithelial tumors, but is extremely rare in bone tumors. An 84-year-old woman experienced swelling and pain in the shoulder for 1 month. Leukocytosis and elevated serum G-CSF were observed, but resolved following tumor resection. A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically. Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF-secreting tumors.

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Leukocytosis as an initial sign of aggressive growth of granulocyte colony-stimulating factor-producing cervical cancer

Cited by 8 publications

References 3 publications

Leukocytosis due to markedly elevated granulocyte-colony stimulating factor levels in a patient with endometrial cancer: Case report and literature review

Leukocytosis due to markedly elevated granulocyte-colony stimulating factor levels in a patient with endometrial cancer: Case report and literature review

Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the lower gingiva: a case report

Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF

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