Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.

Dinges, David F.; Douglas, Steven D.; Zaugg, Line; Campbell, Donald E.; McMann, J M; Whitehouse, Wayne G.; Orne, Emily Carota; Kapoor, Shiv; Icaza, E; Orne, Martin T.

doi:10.1172/jci117184

Cited by 319 publications

(257 citation statements)

References 37 publications

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“…Previous studies have reported a relationship between sleep deprivation and increased leukocytosis (Born et al, 1997;Dinges et al, 1994), which was replicated in this study. The increased neutrophilia observed in this study the morning after sleep deprivation (Fig.…”

Section: Il-8 Productionsupporting

confidence: 85%

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Sleep Deprivation in Humans, Immunodepression and Glutamine Supplementation

Castell¹,

Gough²,

Cardenas³

et al. 2005

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Section: Il-8 Productionsupporting

confidence: 85%

“…(Born et al, 1997;Dinges et al, 1994). It appears that one night's sleep deprivation elevated the platelet count on subsequent days in the Placebo…”

Section: Correlations Among Subjective Ratingsmentioning

confidence: 99%

Sleep Deprivation in Humans, Immunodepression and Glutamine Supplementation

Castell¹,

Gough²,

Cardenas³

et al. 2005

PsycEXTRA Dataset

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“…The effects of sleep on human immune functions (compared with continuous wakefulness) are controversial. Some studies showed that sleep is associated with a reduction in the numbers of immune cell types (16,51), including monocytes and T lymphocytes, whereas other studies reported an enhancement or no change (51)(52)(53). The situation is more complex for cytokines, with some affected (increase and decrease) and others unchanged, with discrepancies observed among studies (38).…”

Section: Discussionmentioning

confidence: 99%

Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Cuesta

Boudreau

Dubeau-Laramée

et al. 2016

The Journal of Immunology

107

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Recent research unveiled a circadian regulation of the immune system in rodents, yet little is known about rhythms of immune functions in humans and how they are affected by circadian disruption. In this study, we assessed rhythms of cytokine secretion by immune cells and tested their response to simulated night shifts. PBMCs were collected from nine participants kept in constant posture over 24 h under a day-oriented schedule (baseline) and after 3 d under a night-oriented schedule. Monocytes and T lymphocytes were stimulated with LPS and PHA, respectively. At baseline, a bimodal rhythmic secretion was detected for IL-1β, IL-6, and TNF-α: a night peak was primarily due to a higher responsiveness of monocytes, and a day peak was partly due to a higher proportion of monocytes. A rhythmic release was also observed for IL-2 and IFN-γ, with a nighttime peak due to a higher cell count and responsiveness of T lymphocytes. Following night shifts, with the exception of IL-2, cytokine secretion was still rhythmic but with peak levels phase advanced by 4.5–6 h, whereas the rhythm in monocyte and T lymphocyte numbers was not shifted. This suggests distinct mechanisms of regulation between responsiveness to stimuli and cell numbers of the human immune system. Under a night-oriented schedule, only cytokine release was partly shifted in response to the change in the sleep–wake cycle. This led to a desynchronization of rhythmic immune parameters, which might contribute to the increased risk for infection, autoimmune diseases, cardiovascular and metabolic disorders, and cancer reported in shift workers.

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“…There are several laboratory studies that have used simulated night work to investigate the effects of partial or total sleep deprivation on immune function [6][7][8][9][10][11] . Both enhancing and suppressive effects on NK cell activity and lymphocyte subsets have been reported.…”

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confidence: 99%

Effects of Fatigue on Immune Function in Nurses Performing Shift Work

Nagai

Morikawa

Kitaoka-Higashiguchi

et al. 2011

Journal of Occupational Health

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Effects of Fatigue on Immune Function in Nurses PerformingShift Work: Makie Nagai, et al. Department of Epidemiology and Public Health, Kanazawa Medical University-Objectives:We investigated the effects of fatigue on NK cell function and lymphocyte subpopulations in nurses performing shift work using a longitudinal design. Methods: Fiftyseven female nurses engaged in shift work at a hospital in Japan were selected for our study cohort. The hospital used a counterclockwise rotating three-shift system. Night shifts followed day shifts after a sevenhour interval. Immune parameters measured at the beginning of the day shift through to the end of the night shift were compared between two groups stratified by their level of fatigue. Statistical differences were evaluated after adjusting for baseline immune values and other demographic features. Results: Subjective feelings of fatigue increased progressively from the beginning of day shifts to the end of night shifts. From the beginning of day shifts to the end of night shifts, NK cell activity and CD16 + CD56 + lymphocytes decreased, while CD3 + and CD4 + lymphocytes increased. The group with the greater increase in fatigue showed a larger decrease in NK cell activity and a larger increase in CD4 + lymphocytes when compared with the group reporting less fatigue. These findings did not change after adjusting for demographic factors and sleep hours. Conclusion: Our data suggest that shift work has deleterious effects on NK cell function and that the effects depend on the degree of fatigue. Proper management of shift work may lessen fatigue in workers and also ameliorate many health problems experienced by shift workers. (J Occup Health 2011; 53: 312-319)

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Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation.

Cited by 319 publications

References 37 publications

Sleep Deprivation in Humans, Immunodepression and Glutamine Supplementation

Sleep Deprivation in Humans, Immunodepression and Glutamine Supplementation

Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Effects of Fatigue on Immune Function in Nurses Performing Shift Work

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