“…However, sparing phenomenon in the setting of generalized drug rash remains a poorly understood entity and has been reported in only a handful of cases including sparing of a leprosy macule in ampicillin hypersensitivity rash, sparing of leprosy patch in dapsone hypersensitivity syndrome, nafcillin-related leukocytoclastic vasculitis sparing a tattoo, and phenobarbital drug rash sparing NDP. 8 , 9 , 10 , 11 Of previously reported cases, local immune dysfunction was consistently posited as a potential pathophysiologic mechanism of skin disease sparing. Therefore, sparing of NA may be more complex than what available research suggests.…”