“…Extra-cutaneous symptoms, which include severe angioedema, cough, shortness of breath, sore throat, and dysphagia, occur rarely [ 4 ]. LCV may develop secondary to a side effect of medication such as NSAIDs, phenytoin, and anti-TNF-a, as well as infections, neoplasms, and systemic inflammatory disorders [ 5 ]. A definitive diagnosis is made with a skin biopsy, which typically shows perivascular and vascular leukocytic infiltrates in addition to fibrinoid necrosis [ 4 ].…”