Leukocytoclastic vasculitis as a complication of granulocyte colony-stimulating factor (G-CSF) – a case study

Andavolu, M. V. S.; Logan, L. J.

doi:10.1007/s002770050476

Cited by 6 publications

(4 citation statements)

References 14 publications

(16 reference statements)

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“…ALV is an extremely rare complication of G-CSF treatment in neutropenic patients. Previous reports have shown a likely correlation between the absolute neutrophil count (ANC) and the incidence of vasculitis 3 4. Compared with previous reports, our patient displayed anti-Ro/La autoantibody positivity.…”

Section: Discussioncontrasting

confidence: 53%

“…Compared with previous reports, our patient displayed anti-Ro/La autoantibody positivity. This might suggest that coexistence of underlying inflammatory conditions, which are known to predispose to immune complex formation3 4 and activate FCγ receptors on neutrophils,5–8 could have played a factor in the development of vasculitis (figure 3). Interestingly, G-CSF administration has also been shown to trigger vasculitis in neutropenic patients with SLE 9.…”

Section: Discussionmentioning

confidence: 99%

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Granulocyte colony-stimulating factor as a cause of acute leucocytoclastic vasculitis with anti-Ro and anti-La antibodies

et al. 2022

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Granulocyte colony-stimulating factor (G-CSF) administration is associated with a diverse range of cutaneous sequelae. Serious dermatological side effects of G-CSF include the development of Sweet’s syndrome and exacerbations of pre-existing inflammatory disorders such as psoriasis. Here, we describe a report of acute leucocytoclastic vasculitis caused by G-CSF therapy associated with anti-Ro and anti-La antibodies in a patient with multiple myeloma. This case highlights the importance of having a high index of suspicion for acute leucocytoclastic vasculitis in patients with haematological malignancies undergoing G-CSF therapy.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Granulocyte colony-stimulating factor as a cause of acute leucocytoclastic vasculitis with anti-Ro and anti-La antibodies

et al. 2022

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“…Localized reactions at the site of injection are characterized by urticarial wheals with edema although lichenoid reactions have also been described [8,9,10]. Development of neutrophilic dermatoses such as Sweet’s syndrome [11,12,13], pyoderma gangrenosum [14, 15], neutrophilic eccrine hidradenitis [16], leukocytoclastic vasculitis [17,18,19] and folliculitis [20] have occasionally been reported. In some instances, exacerbation of certain diseases, such as acne [21] or psoriasis [22, 23], has also been noted.…”

Section: Commentmentioning

confidence: 99%

Granulomatous Dermatitis with Enlarged Histiocytes: A Characteristic Pattern of Granulocyte Colony-Stimulating Factor

et al. 2006

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Two patients developed a pruritic maculopapular rash following treatment with granulocyte colony-stimulating factor (G-CSF). Histopathological examination disclosed a superficial dermal inflammatory infiltrate composed of interstitially arranged large histiocytic CD68+ cells and perivascularly disposed lymphocytes. Large histiocytes were interspersed among the collagen bundles with associated slight deposits of mucin. Elastophagocytosis was occasionally observed, and a slight reduction of dermal elastic fibers was also noted. There was no evidence of frank granuloma formation, fibrosis or significant changes of collagen bundles. This histopathological variant of granulomatous dermatitis with ‘enlarged histiocytes’ seems to be characteristic of an unusual cutaneous reaction secondary to CSF treatment.

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“…We found 18 cases of vasculitis after infusion of G-CSF. However, one study of 12 patients gave limited information (Table 1) [4][5][6][7][8][9] . Skin lesions developed within two days to one month after receiving G-CSF.…”

Section: Case Reportmentioning

confidence: 99%

A Case of Cutaneous Leukocytoclastic Vasculitis Associated with Granulocyte Colony-Stimulating Factor: An Unusual Presentation

Yoon

Byun

et al. 2020

Ann Dermatol

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Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.

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Leukocytoclastic vasculitis as a complication of granulocyte colony-stimulating factor (G-CSF) – a case study

Cited by 6 publications

References 14 publications

Granulocyte colony-stimulating factor as a cause of acute leucocytoclastic vasculitis with anti-Ro and anti-La antibodies

Granulocyte colony-stimulating factor as a cause of acute leucocytoclastic vasculitis with anti-Ro and anti-La antibodies

Granulomatous Dermatitis with Enlarged Histiocytes: A Characteristic Pattern of Granulocyte Colony-Stimulating Factor

A Case of Cutaneous Leukocytoclastic Vasculitis Associated with Granulocyte Colony-Stimulating Factor: An Unusual Presentation

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