Leukocytoclastic vasculitis (anaphylactoid purpura): a unique occurrence in the oral cavity.

Abstract

Leukocytoclastic vasculitis, immune complex disorder (type III), is a skin disease with both an acute form characterized by bullae, vesicles and ulcerations, and a chronic form characterized by petechiae, macules and ulcerations. The disease presents certain systemic features including diffuse or focal glomerulonephritis and renal failure. The histopathologic characteristics of leukocytoclastic vasculitis in the skin appear primarily in small blood vessels and consist of an infiltration of inflammatory cells, leukoclasis, swelling of endothelial cells, occlusion of blood vessels, accumulation of fibrin and fibrinoid degeneration, as well as the presence of immune complexes in and around blood vessel walls. Although leukocytoclastic vasculitis is described as several diseases which can spread systemically, including the gastrointestinal tract and the kidneys, the manifestations of the disease in the oral cavity have not yet been reported. The present paper reports unique oral lesions in a 38-yr-old woman, diagnosed as leukocytoclastic vasculitis, without any accompanying skin or systemic lesions.

Possible roles of anti-type II collagen antibody and innate immunity in the development and progression of diabetic retinopathy

“…The pathological features of Arthus reaction are bleeding, thrombosis, and edema [ 89 ], then followed by fibrinoid deposition, as observed in the RA joint [ 90 ]. Fibrinoid is mainly composed of fibrin and immune complexes [ 91 ], of which deposition has reportedly been detected in the joint tissues of RA patients [ 92 ].…”

An extraordinary case of oral leukocytoclastic vasculitis demonstrating igd deposition around dermal vessels and within mucosal keratinocytes

“…These vasculitides often share clinical and immunohistopathologic features [1,2]. The vasculitides are associated with blood vessel inflammation that can cause internal organ damage [1][2][3].…”

“…The American College of Rheumatology (ACR) recommends standards for cataloging the primary vasculitides, established via a compilation of clinical and immunological characteristics of multiple patients. The following are types of characterized vasculitis: Takayasu arteritis, polyarteritis nodosa (PAN), WG, giant cell arteritis, and Henoch-Schönlein purpura (currently known as IgA vasculitis) [3][4][5][6][7][8][9][10][11].…”