Leukocytoclastic vasculitis: An uncommon adverse effect of a common drug

Abstract

A hypertensive elderly male on amlodipine presented with a palpable purpuric rash on both legs followed by shoulder, buttocks, and back with foot ulcer, which was found to be leukocytoclastic vasculitis on skin biopsy. The patient recovered completely on discontinuation of amlodipine and short-term steroid.

Cutaneous leukocytoclastic vasculitis associated with verapamil and atorvastatin: A case report

“…Calcium channel blockers and statins have been rarely associated with leukocytoclastic vasculitis, with only a few case reports in the literature. [2][3][4][5][6] Of calcium channel blockers, only diltiazem, 3 lercarnidipine, 4 and amlodipine 5 have been implicated. We present a case of leukocytoclastic vasculitis associated with atorvastatin and verapamil.…”

“…1 Leukocytoclastic vasculitis is a small-vessel vasculitis predominantly affecting dermal capillaries and venules, and often secondary to underlying systemic vasculitis, infection or drug exposure. 1 Commonly implicated drugs include beta-lactam antibiotics and non-steroidal anti-inflammatory drugs, 1 while calcium channel blockers and hydroxymethylglutaryl-coA reductase inhibitors (statins) have been rarely associated [2][3][4][5][6] -with no previous formal case report for verapamil. We present a case of cutaneous leukocytoclastic vasculitis associated with recently initiated verapamil and atorvastatin.…”

Cutaneous leukocytoclastic vasculitis associated with verapamil and atorvastatin: A case report

“…Calcium channel blockers and statins have been rarely associated with leukocytoclastic vasculitis. A literature search of PubMed and Google Scholar using the terms “leukocytoclastic vasculitis”, “cryoglobulin”, “calcium channel blocker” “verapamil”, “statin” and “atorvastatin” yielded only a few similar case reports 2–6 . Among the calcium channel blockers, only diltiazem, 3 lercarnidipine, 4 and amlodipine 5 have been implicated.…”

“… 1 Leukocytoclastic vasculitis is a small‐vessel vasculitis predominantly affecting dermal capillaries and venules, and often secondary to underlying systemic vasculitis, infection, or drug exposure. 1 Commonly implicated drugs include beta‐lactam antibiotics and nonsteroidal anti‐inflammatory drugs, 1 while calcium channel blockers and hydroxymethylglutaryl‐coA reductase inhibitors (statins) have been rarely associated 2 , 3 , 4 , 5 , 6 —with no previous formal case report for verapamil. We present a case of cutaneous leukocytoclastic vasculitis associated with recently initiated verapamil and atorvastatin.…”

A Rare Cutaneous Manifestation: Leukocytoclastic Vasculitis after Pfizer-BioNTech COVID-19 Vaccination

“…Half of all cases of LCV are idiopathic but secondary causes such as infections and medications have been proposed as the most common triggers [ 7 ]. The medications commonly known to cause LCV are beta-lactams, erythromycin, clindamycin, quinolones, vancomycin, sulfonamide, furosemide, allopurinol, NSAIDs, amiodarone, beta-blockers, TNF-alpha inhibitors, SSRIs, metformin, and warfarin [ 2 , 8 ]. In addition, several vaccines, including those against influenza, HBV, BCG, and HPV, have been implicated in the development of LCV [ 7 , 9 ].…”