Leukocytes influence peripheral tissue oxygenation and perfusion in neonates

Pichler, Gerhard; Binder, Corinna; Urlesberger, Berndt; Morris, Nicholas; Schwaberger, Bernhard; Riedl, Regina

doi:10.22514/sv82.102013.3

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Two studies included pFOE measurements on the forearm of preterm neonates with anemia after the seventh day after birth ( 2 , 30 ). pFOE measurements on the calf were described in preterm neonates with patent ductus arteriosus between 12 and 24 h ( 24 ) and in neonates with leukocytosis between 48 and 72 h ( 31 ) after birth.…”

Section: Resultsmentioning

confidence: 99%

“…In preterm neonates peripheral muscle NIRS measurements have been demonstrated to provide useful information in case of anemia ( 2 , 30 ) and hypotension ( 13 , 17 ), as well as in a potential influence of patent ductus arteriosus ( 24 ) and elevated leukocyte counts ( 31 ). In term neonates peripheral muscle NIRS measurements may provide additional information on exposure to certain risk factors, including maternal smoking during pregnancy ( 26 ), perinatal asphyxia ( 32 ) and elevated C reactive protein (CRP) values ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…At early stages of inflammation when other routine vital parameters are still within normal ranges, pFOE has been demonstrated to provide useful information ( 1 , 33 ). Binder et al ( 31 ) examined associations between leukocyte counts and peripheral tissue oxygenation in preterm and term neonates within the first 2 months after birth. Peripheral tissue oxygen consumption decreased and vascular resistance increased with higher leukocyte counts, but no association between pFOE and leukocyte counts could be observed.…”

Section: Discussionmentioning

confidence: 99%

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Peripheral fractional oxygen extraction measured with near-infrared spectroscopy in neonates—A systematic qualitative review

et al. 2022

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BackgroundPeripheral fractional oxygen extraction (pFOE) measured with near-infrared spectroscopy (NIRS) in combination with venous occlusion is of increasing interest in term and preterm neonates.ObjectiveThe aim was to perform a systematic qualitative review of literature on the clinical use of pFOE in term and preterm neonates and on the changes in pFOE values over time.MethodsA systematic search of PubMed, Embase and Medline was performed using following terms: newborn, infant, neonate, preterm, term, near-infrared spectroscopy, NIRS, oximetry, spectroscopy, tissue, muscle, peripheral, arm, calf, pFOE, OE, oxygen extraction, fractional oxygen extraction, peripheral perfusion and peripheral oxygenation. Additional articles were identified by manual search of cited references. Only studies in human neonates were included.ResultsNineteen studies were identified describing pFOE measured with NIRS in combination with venous occlusion. Nine studies described pFOE measured on the forearm and calf at different time points after birth, both in stable preterm and term neonates without medical/respiratory support or any pathological findings. Nine studies described pFOE measured at different time points in sick preterm and term neonates presenting with signs of infection/inflammation, anemia, arterial hypotension, patent ductus arteriosus, asphyxia or prenatal tobacco exposure. One study described pFOE both, in neonates with and without pathological findings.ConclusionThis systematic review demonstrates that pFOE may provide additional insight into peripheral perfusion and oxygenation, as well as into disturbances of microcirculation caused by centralization in preterm and term neonates with different pathological findings.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42021249235].

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Peripheral fractional oxygen extraction measured with near-infrared spectroscopy in neonates—A systematic qualitative review

et al. 2022

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“…In this post-hoc analysis, secondary outcome parameters obtained in five prospective observational studies with peripheral muscle oxygenation measurements during the first 24 h after birth were analyzed ( 10 , 14 , 15 ). These studies were conducted between January 2008 and December 2022 at the Division of Neonatology, Medical University of Graz, Austria.…”

Section: Methodsmentioning

confidence: 99%

Peripheral muscle fractional tissue oxygen extraction in stable term and preterm neonates during the first 24 h after birth

Wolfsberger,

Höller,

Baik-Schneditz

et al. 2023

Front. Pediatr.

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BackgroundPeripheral muscle fractional tissue oxygen extraction (pFTOE) represents the relative extraction of oxygen from the arterial to venous compartment, providing information about dynamic changes of oxygen delivery and oxygen consumption. The aim of the present study was to establish reference values of pFTOE during the first 24 h after birth in stable term and late preterm neonates.MethodsThe present study is a post-hoc analysis of secondary outcome parameters of prospective observational studies. Only stable neonates without infection, asphyxia and any medical support were eligible for our analysis to obtain normal values. For measurements of peripheral muscle tissue oxygenation index (pTOI) during the first 24 h after birth in term and preterm neonates, the NIRO200/NIRO200NX was used. Arterial oxygen saturation (SpO2) was obtained by pulse oximetry. pFTOE was calculated out of pTOI and SpO2: pFTOE = (SpO2-pTOI)/SpO2. Measurements of neonates were stratified into four groups according to their respective measurement time point (6 h periods) after birth. Term and preterm neonates were analyzed separately. Mean values of measurements during the first time period (0–6 h after birth) were compared to measurements of the following time periods (second = 7–12 h, third = 13–18 h, fourth = 19–24 h after birth).ResultsTwo-hundred-fourty neonates (55 term and 185 late preterm neonates) had at least one peripheral muscle NIRS measurements within the first 24 h after birth. Mean gestational age and birth weight were 39.4 ± 1.1 weeks and 3360 (2860–3680)g in term neonates and 34.0 ± 1.4 weeks and 2060 (1750–2350)g in preterm neonates, respectively. In term neonates pFTOE was 0.264 (0.229–0.300), 0.228 (0.192–0.264), 0.237 (0.200–0.274) and 0.220 (0.186–0.254) in the first, second, third and fourth time period. In preterm neonates pFTOE was 0.229 (0.213–0.246), 0.225 (0.209–0.240), 0.226 (0.210–0.242) and 0.238 (0.222–0.255) in the first, second, third and fourth time period. pFTOE did not show any significant changes between the time periods, neither in term nor in preterm neonates.ConclusionWe provide reference values of pFTOE for stable term and late preterm neonates within the first 24 h after birth, which were stable when comparing four 6-h periods. These normal values are of great need for interpreting pFTOE in scientific context as well as for potential future clinical applications.

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Changes in peripheral muscle oxygenation measured with near-infrared spectroscopy in preterm neonates within the first 24 h after birth

et al. 2020

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Background: Near-infrared spectroscopy (NIRS) combined with venous occlusions enables peripheral-muscle oxygenation and perfusion monitoring. Objective: The aim of the present exploratory observational study was to evaluate peripheral-muscle oxygenation and perfusion during the first 24 h after birth in stable preterm neonates. Approach: Secondary outcome parameters of prospective observational studies were analysed. Preterm neonates with peripheral-muscle NIRS measurements combined with venous occlusion on the first day after birth were included. Neonates without circulatory support and without signs of infection/inflammation were included. Neonates were stratified in four groups according to their measurement time-point (6 h-periods) and matched 2:1 for gestational age ±1 week. For each group haemoglobin flow (Hbflow), oxygen-delivery (DO2), oxygen-consumption (VO2), fractional-oxygen-extraction (FOE), tissue-oxygenation-index (TOI) and mixed-venous-oxygenation (SvO2) were calculated. Neonates with measurements during the first 6-hour time period were compared to neonates with measurements of the following time periods. Main results: 40 preterm neonates (gestational age (median(IQR)): 33.5(32.5–34.1)weeks) measured during the first 6 h period after birth were compared to 20 preterm neonates measured in each of the following 6 h periods (period two: 33.7(33.1–34.3)weeks; period three: 34.1(33.2–34.6)weeks; period four: 33.8(32.6–34.6)weeks). Hbflow, DO2 and SvO2 were significantly higher in the second and third 6 h time period compared to the first 6 h period. VO2 did not change significantly during the first day after birth. FOE was significantly lower in the second, third and fourth time period compared to the first 6 h period. TOI showed a non-significant trend towards higher values in the third period compared to the first 6 h period. Significance: In preterm neonates Hbflow, DO2, SvO2 increased, FOE decreased and TOI showed a trend towards increase during the first day after birth, whereas VO2 did not change. Changes of peripheral-muscle oxygenation during the first day after birth in stable preterm neonates are different to already published changes thereafter.

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Leukocytes influence peripheral tissue oxygenation and perfusion in neonates

Cited by 3 publications

References 16 publications

Peripheral fractional oxygen extraction measured with near-infrared spectroscopy in neonates—A systematic qualitative review

Peripheral fractional oxygen extraction measured with near-infrared spectroscopy in neonates—A systematic qualitative review

Peripheral muscle fractional tissue oxygen extraction in stable term and preterm neonates during the first 24 h after birth

Changes in peripheral muscle oxygenation measured with near-infrared spectroscopy in preterm neonates within the first 24 h after birth

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