Leukocytes and the Natural History of Deep Vein Thrombosis

Saha, Prakash; Humphries, Julia; Modarai, Bijan; Mattock, Katherine; Waltham, Matthew; Evans, Colin E.; Ahmad, Abdul Hamid; Patel, Alpesh; Premaratne, Sobath; Lyons, Oliver; Smith, Alberto

doi:10.1161/atvbaha.110.213405

Cited by 162 publications

(156 citation statements)

References 95 publications

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“…Most prominently, these include venous stasis, blood hypercoagulability, and damage to blood vessel walls [2,55]. Unlike typical blood clots, which form as a collection of erythrocytes on a fibrin mesh, VTE develop in several laminar layers of platelets, leukocytes, and fibrin, which surround a nucleus of erythrocytes [2,56].…”

Section: Pathogenesismentioning

confidence: 99%

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Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Coté¹,

Smith

2015

J Hematol Thrombo Dis

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Venous thromboembolism (VTE) is a relatively common and well-described condition, affecting approximately 1-2% of the general population. VTE can lead to significant morbidity and death via pulmonary embolism (PE). During the post-operative period, VTE occurs at higher rates due to natural thrombotic responses to injury and limited post-operative mobility. In general, rates of post-operative VTE are higher in patients undergoing operations for cranial and spinal lesions than for lesions of other types, a phenomenon that is not fully explained. Several studies have demonstrated that other risk factors for VTE include age, sex, ethnicity, hospital stay length, and coagulation state. Aggressive chemical and mechanical measures for VTE prophylaxis are indicated in the postoperative period to prevent the formation of VTE. Here we review the literature on VTE in brain tumor patients, with a focus on their etiology, diagnosis, treatment, and prophylaxis.

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Section: Pathogenesismentioning

confidence: 99%

“…Venous thromboemboli (VTE) occur regularly in 1-2% of the general population, with an annual incidence of 1 in 500 [1,2]. VTE can cause death via pulmonary emboli (PE) or significant disability via pain, edema, and post-thrombotic syndrome, a form of venous reflux that occurs secondary to deep vein thrombosis (DVT).…”

Section: Introductionmentioning

confidence: 99%

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Coté¹,

Smith

2015

J Hematol Thrombo Dis

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“…DVT is potentially fatal due to its sequelae pulmonary embolism and postthrombotic syndrome, making DVT an economic burden on the healthcare service [3]. However, the pathophysiology of DVT is still not clear.…”

Section: Introductionmentioning

confidence: 99%

MMP-3-1612 polymorphism - a risk factor for deep venous thrombosis formation

Nai-xuan

Sheng

2016

Vasa

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Summary: Background:We investigated the association of the 5A/6A polymorphism in the promoter region at -1612 of the matrix metalloproteinase-3 gene (MMP-3-1612) and deep venous thrombosis (DVT). Patients, materials and methods: The distribution of the MMP-3 (-1612 5A/6A) polymorphism in the case and control groups was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum MMP-3 level of two groups was detected using enzyme-linked immunosorbent assay (ELISA). HepG2 cells containing MMP-3-1612 recombinant plasmid were cultured in vitro and the MMP-3 level was defined by luminescence intensity of luciferase. A DVT rat model was built. Serum MMP-3 level in the rats' wounded vein at different time points was detected by ELISA and recorded for investigation of the association between MMP-3 and DVT. Statistical data analysis was conducted with SPSS18.0. Results: On the basis of the observation of MMP-3-1612 genotype frequency and allele frequency in the case and control groups, we identified significantly higher MMP-3-1612 5A allele frequency and higher serum MMP-3 level in the case group than in the control group (both P < 0.05). According to in vitro luciferase measurements, the 5A allele had higher transcriptional activity than the 6A allele. As observed in the rat model, serum MMP-3 level increased with time passing and thrombosis formation after modelling. Conclusions: The MMP-3-1612 5A/6A polymorphism may effect serum MMP-3 level and over-expression of serum MMP-3 level may be a risk factor for DVT formation.

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“…The inflammatory process is increasingly being recognized as an important mechanism regulating thrombus formation and resolution [6,7]. Biomarkers for inflammation, including C-reactive protein, have been reported to be increased in patients with VTE [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…The lysis of red blood cells (RBCs) abundant in the early thrombus may contribute to further endothelial dysfunction and thrombus propagation through cascading RBC lysis. Free heme from the released hemoglobin is highly inflammatory and a major source of oxidative stress on the endothelium [7,10,11].…”

Section: Introductionmentioning

confidence: 99%

Increased risk of venous thromboembolism is associated with genetic variation in heme oxygenase-1 in Blacks

Bean¹,

Boulet²,

Ellingsen³

et al. 2012

Thrombosis Research

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Background-Venous thromboembolism (VTE) affects as many as 1 in 1000 individuals in the United States. Although Blacks are disproportionately affected by VTE, few genetic risk factors have been identified in this population. The inducible heme oxygenase-1 (HMOX1) gene encodes a key cytoprotective enzyme with anti-inflammatory, antioxidant and anticoagulant activity acting in the vascular system. A (GT) n microsatellite located in the promoter of the HMOX1 gene influences the level of response.

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Leukocytes and the Natural History of Deep Vein Thrombosis

Abstract: Abstract-Observational

Cited by 162 publications

References 95 publications

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

Venous Thromboembolism in Brain Tumor Patients: A Review of Literature

MMP-3-1612 polymorphism - a risk factor for deep venous thrombosis formation

Increased risk of venous thromboembolism is associated with genetic variation in heme oxygenase-1 in Blacks

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