Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population

Liu, Yiwen; Ma, Chifa; Li, Pingping; Ma, Chunxiao; He, Song; Ping, Fan; Zhang, Huabing; Li, Wei; Xu, Lingling; Li, Yuxiu

doi:10.1155/2020/9256107

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…Short TL increases the risk of diabetes. The normoglycemic population with shorter TL had a high risk of developing diabetes [10]. Hyperglycemia, which increases oxidative stress, accelerates the TL shortening especially in islet β cells, causing β cell dysfunction and reduced insulin secretion [11].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Molecular Studies of Different Parameters as Markers for Nephropathy in Type 1 Diabetic Patients

Soliman¹,

Abd-Elghffar²

2022

Series Endo Diab Met

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Albuminuria is the most characteristic marker of diabetic nephropathy (DN), which is a diabetic complication associated with DN progression. However, renal functions decreased by about one-third of diabetic patients before the occurrence of albuminuria. We study the role of telomere length (TL) of blood leukocytes, some inflammatory markers in the progression of DN in patients with type 1 diabetes (T1D). Volunteers were selected and distributed into four groups: group 1 included 20 healthy subjects as control, group 2: 20 T1D patients with albumin excretion rate (AER) < 30 mg/gm creatinine, group 3: 15 T1D patients with (300 > AER > 30 mg/gm creatinine), group 4: 15 T1D patients with (AER > 300 mg/gm creatinine) and group 5 (DN group), which is a collective group between group 3 and group 4. Glycated haemoglobin (HbA1c), serum urea, creatinine, malondialdehyde (MDA), 8-OHdG, and TL in leukocytes were measured. Results showed a significant increase in HbA1c, creatinine, urea, 8-OHdG, transforming growth factor β1 (TGF-β1), MDA and decrease in TL in G2, G3, G4, and G5 compared with control with a p-value < 0.05.

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Section: Introductionmentioning

confidence: 99%

Biochemical and Molecular Studies of Different Parameters as Markers for Nephropathy in Type 1 Diabetic Patients

Soliman¹,

Abd-Elghffar²

2022

Series Endo Diab Met

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“…For glucose metabolic traits, HOMA-IR, which estimates insulin resistance, was significantly and negatively associated with LTL in other studies in adults [2,5]. One study, which tried to predict diabetes progression with baseline LTL in 108 Chinese adults, reported a positive association between adulthood LTL and the Matsuda Index [27], which provides a measure of whole-body insulin sensitivity [28]. A Danish cohort consisting of teenage offspring of mothers with or without GDM also reported a negative association between LTL in 9-to 16-year-old females and their HOMA-IR and fasting insulin levels [23].…”

Section: Discussionmentioning

confidence: 93%

Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study

Wong

Cheng

Lim

et al. 2022

BMC Med

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Background Leukocyte telomere length (LTL) is suggested to be a biomarker of biological age and reported to be associated with metabolic diseases such as type 2 diabetes. Glucose metabolic traits including glucose and insulin levels have been reported to be associated with LTL in adulthood. However, there is relatively little research focusing on children’s LTL and the association with prenatal exposures. This study investigates the relationship between maternal and offspring glucose metabolism with offspring LTL in early life. Methods This study included 882 mother-child pairs from the HAPO Hong Kong Field Centre, with children evaluated at age 7.0 ± 0.4 (mean ± SD) years. Glucose metabolic traits including maternal post-load glucose during pregnancy, children’s glucose and insulin levels, and their derived indices at follow-up were measured or calculated. Offspring LTL was assessed using real-time polymerase chain reaction. Results Sex- and age-adjusted children’s LTL was found to be associated with children’s HOMA-IR (β=−0.046 ± 0.016, p=0.005). Interestingly, both children’s and maternal post-load glucose levels were positively associated with children’s LTL. However, negative associations were observed between children’s LTL and children’s OGTT insulin levels. In addition, the LTL in females was more strongly associated with pancreatic beta-cell function whilst LTL in males was more strongly associated with OGTT glucose levels. Conclusions Our findings suggest a close association between maternal and offspring glucose metabolic traits with early life LTL, with the offspring sex as an important modifier of the disparate relationships in insulin production and response.

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“…Telomere length may serve as a potential biomarker to assess, predict, and monitor overall health. Telomere shortening is associated with aging-related conditions, including cardiovascular disease [17], diabetes mellitus [18], some types of cancer [19], physical activity [20], and Alzheimer’s disease [21].…”

Section: Introductionmentioning

confidence: 99%

Physical performance and telomere length in older adults

Martínez-Ezquerro,

Ortiz-Ramírez,

García-delaTorre

et al. 2023

Preprint

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BackgroundThe fast-paced aging demographic prompts studying risk factors and markers that could predict healthy aging. Telomere length shows promise for assessing a broad spectrum of aging-related phenotypes.Aim of the studyTo assess the association between physical performance and telomere length in Mexican older adults.MethodsIn this observational cross-sectional study, we recruited 323 older adults affiliated with the Instituto Mexicano del Seguro Social (IMSS) and members of the “Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults’’ (COSFOMA). To assess physical performance, we used the Short Physical Performance Battery (SPPB) and stratified individuals into two groups according to their SPPB score into low ≤7 (L-SPPB) and high >7 (H-SPPB). Absolute telomere length (aTL) was determined by using qPCR. Next, we classified individuals according to their aTL into short ≤4.22 kb (S-TL) and long >4.22 kb (L-TL). For both SPPB and aTL categories, we calculated the mean and adjusted mean by sex, age, marital status, education, remunerated work, smoking, drinking, cognitive decline, depression, and polypharmacy with 95% CI, including the lower and upper CI (LCImeanUCI). We estimated the effect size between physical performance and telomere length with Cohen’s d for unequal group sizes. Also, we calculated the odds ratio with 95% confidence intervals, including the lower and upper CI (LCIORUCI) for physical performance according to telomere length categories.ResultsParticipants in the low physical performance category had significantly shorter telomeres (4.14.44.7mean and3.54.04.5kb adjusted mean, p<0.001), in opposition to the high physical performance category (score >7) with longer telomeres (5.55.75.9mean and4.75.35.8kb adjusted mean, p<0.001), with a medium-to-high telomere length effect size (d= 0.762). Finally, the odds of being classified in the low physical activity category increased2.13.66.1times per kb of telomere (adjOR1.73.36.3, p<0.001) compared to the high physical activity group (p<0.001).ConclusionDecreased physical functioning is associated with lower telomere length. Absolute telomere length (aTL) as a possible biomarker for differential diagnosis of healthy and unhealthy aging should be explored further.

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Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population

Cited by 9 publications

References 45 publications

Biochemical and Molecular Studies of Different Parameters as Markers for Nephropathy in Type 1 Diabetic Patients

Biochemical and Molecular Studies of Different Parameters as Markers for Nephropathy in Type 1 Diabetic Patients

Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study

Physical performance and telomere length in older adults

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