Leukocyte telomere length and age at menopause

Gray, Kristen E.; Schiff, Melissa A.; Fitzpatrick, A.; Starr, Jacqueline R.

doi:10.1016/j.fertnstert.2012.07.164

Cited by 6 publications

(9 citation statements)

References 31 publications

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“…Another explanation for worse lung function in women who had an early cessation of menstruation may be related "biological aging". Some studies have shown lower FVC and FEV1 in those with shorter leukocyte telomeres (a marker of faster biological aging) [29,30], which in turn have been suggested to be a marker of early menopause [31].…”

Section: Discussionmentioning

confidence: 99%

Lower lung function associates with cessation of menstruation: UK Biobank data

et al. 2016

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Little is known about the effect of cessation of menstruation on lung function. The aims of the study were to examine the association of lung function with natural and surgical cessation of menstruation, and assess whether lower lung function is associated with earlier age at cessation of menstruation.The study was performed in 141 076 women from the UK Biobank, who had provided acceptable and reproducible spirometry measurements and information on menstrual status. The associations of lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), spirometric restriction (FVC < lower limit of normal (LLN)), airflow obstruction (FEV1/FVC

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Section: Discussionmentioning

confidence: 99%

Lower lung function associates with cessation of menstruation: UK Biobank data

et al. 2016

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“…Firstly, studies to date are all cross-sectional, thus, comparing offspring of different parents that reproduced at different ages. Cross-sectional trends may differ from age related changes within individual parents when individuals with long TL are more likely to reproduce at older ages, which is not unlikely given the positive correlation between human TL and reproductive lifespan (22,23). Secondly, parental age effects on offspring TL may arise from effects of parental age on developmental conditions prior to sampling.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic inheritance of telomere length in wild birds

Bauch

Boonekamp

Korsten

et al. 2018

Preprint

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Abstract:Telomere length (TL) predicts health and lifespan in humans and other organisms, making the identification of the causes of TL variation of interest. At conception, zygotes inherit genes that regulate TL during early development, but at the same time already express a phenotype, which is the TL of the parental gametes that formed the zygote. Whether the effect of gamete TL is transient or affects TL for life depends on the extent to which regulatory genes compensate for gamete TL variation during early development. A carry-over effect of parental TL, resulting in epigenetic inheritance, has been suggested to explain the observed relationship between parental age and offspring TL in humans and other species. However, reports of parental age effects are based on cross-sectional data, and age at reproduction has numerous confounds. Furthermore, parental age may affect offspring telomere dynamics between conception and sampling, which could also explain the paternal age effect. Using longitudinal telomere data of jackdaw parents and their chicks, we show that chicks hatched with shorter telomeres as individual fathers aged, whereas mother age had no effect. By crossfostering eggs, we confirmed the paternal age effect to be independent of paternal care after conception. The epigenetic effect accounted for 34% of the variance in offspring TL that was explained by paternal telomere length; the remaining 66% we ascribe to a combination of environmental and additive genetic effects. Thus, our results strongly indicate epigenetic inheritance of TL, with potential consequences for offspring fitness prospects.. CC-BY-NC-ND 4.0 International license not peer-reviewed) is the author/funder. It is made available under aThe copyright holder for this preprint (which was . http://dx.doi.org/10.1101/284208 doi: bioRxiv preprint first posted online Mar. 18, 2018; Significance statement:Telomeres are DNA-protein structures at chromosome ends and their length predicts remaining lifespan in humans and other organisms. Variation in telomere length is thought to be largely of genetic origin, but telomere inheritance may be unusual because a fertilised cell already has a telomere length (most traits are first expressed later in life). Telomeres shorten with age, and, using long-term individual-based data of jackdaw families, we show that as fathers aged, they produced chicks with shorter telomeres. This shows that paternal telomere length directly affects offspring telomere length, i.e. is inherited genetically but without the involvement of genes. This is known as an epigenetic effect and explained a large part (≥34%) of the telomere resemblance between fathers and their offspring.

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“…Cellular aging in the reproductive system of women occurs at varying ages. Variations in the length of telomeres (TLs) could account for the difference in the age at which women reach menopause [11]. Telomeres are significantly influenced by oxidative stress, because they are rich in G. In addition, physical activity, diet, smoking, and body mass index are among the factors impacting TL.…”

Section: Introductionmentioning

confidence: 99%

Telomere Length in Idiopathic Recurrent Pregnancy Loss

Onat

Çaltekin

Başer

et al. 2021

Z Geburtshilfe Neonatol

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Objective Telomere length is used as an indicator of biological aging. It is well known that one of the most remarkable risk factors of recurrent pregnancy losses is advanced maternal age. The objective of this study was to investigate the correlation between idiopathic recurrent pregnancy loss and telomere length. Method The study group included 40 women, while the control group consisted of 41 healthy women whose age and body mass index were matched. A venous blood sample was taken from all participants into EDTA tubes in the early follicular phase, and telomere length was measured through the qPCR technique. Results When the mean TL of the groups was compared, it was determined that TL was significantly shorter among the iRPL group (7763.89±924.58 base pair) compared to the control group (8398.84±1102.95 base pair) (p<0.006). Whereas FSH and E2 were higher in the iRPL group, TAFC was lower (p<0.001). When the correlation between telomere length and endocrine parameters was statistically tested in the iRPL group, a negative correlation was found between FSH and telomere length (r=-0.437; p<0.001). Conclusion Shortened telomere length might play a role in the etiology of iRPL. We are of the opinion that patients with RPL should be screened for the presence of cardiovascular diseases and other chronic diseases, as is the case for POF.

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Leukocyte telomere length and age at menopause

Cited by 6 publications

References 31 publications

Lower lung function associates with cessation of menstruation: UK Biobank data

Lower lung function associates with cessation of menstruation: UK Biobank data

Epigenetic inheritance of telomere length in wild birds

Telomere Length in Idiopathic Recurrent Pregnancy Loss

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